108 citations
,
January 2003 in “Fertility and Sterility” This study found that flutamide at 250 mg daily modestly improved hair thinning in premenopausal women with hyperandrogenic alopecia over one year, while cyproterone acetate and finasteride were not effective.
June 2003 in “Obstetrical & Gynecological Survey” Hair loss in women can be treated with hormone therapy.
6 citations
,
November 1980 in “Clinical Endocrinology” This study measured plasma testosterone glucosiduronate levels and found no overlap in those with hyperandrogenism compared to normal females, despite normal testosterone and dihydrotestosterone levels in half of the affected patients.
47 citations
,
December 2000 in “Archives of Dermatological Research” This study found that women with androgenetic alopecia showed higher levels of certain hormones and lower levels of sex hormone-binding globulin than healthy controls, potentially linking these factors to alopecia severity.
December 2023 in “Expert Review of Endocrinology & Metabolism” In this study, researchers described hyperandrogenism as a condition resulting from excessive androgen production, which can lead to symptoms like acne, hirsutism, and hair loss, particularly relevant for dermatological evaluation and management in adult females.
3 citations
,
November 2013 in “PubMed”
48 citations
,
February 2014 in “Fertility and Sterility” This study found that androgenic alopecia is present in 22% of women with polycystic ovary syndrome and is associated with acne and hirsutism, but not with increased biochemical hyperandrogenemia or metabolic dysfunction beyond PCOS.
24 citations
,
October 1994 in “Fertility and Sterility” This study suggests that in women with androgenic alopecia and men with premature balding, enhanced 5α-reductase activity and altered androgen conjugation, favoring sulfurylation, may be involved in scalp hair loss.
85 citations
,
June 2006 in “Best Practice & Research Clinical Endocrinology & Metabolism” This review outlines the challenges in diagnosing hyperandrogenism in women, focusing on its manifestations like hirsutism, acne, and virilization, but provides no new results.
40 citations
,
May 1999 in “Journal of The European Academy of Dermatology and Venereology” This article outlines management guidelines for androgenetic alopecia, highlighting that continued treatment with medications like finasteride or minoxidil typically halts progression and improves hair condition in most mild to moderate cases.
22 citations
,
January 2002 in “Treatments in endocrinology” This review examines the role of androgens in cutaneous disorders and the potential therapeutic effects of different oral contraceptives, noting variations in individual responses and the influence of genetic and local factors but reports no new clinical results.
14 citations
,
February 2016 in “Journal of Obstetrics and Gynaecology Research” In this study, the authors concluded that clinical hyperandrogenism is not a reliable predictor for biochemical hyperandrogenism in Thai women with PCOS.
14 citations
,
July 1987 in “Dermatologic Clinics” This article reviews current evaluation and treatment options for androgenic alopecia in women and reports no new clinical results.
6 citations
,
January 2009 In PCOS, high male hormones cause hair growth, acne, and hair loss, affecting periods.
4 citations
,
January 1989 in “Journal of Steroid Biochemistry” This study suggests that 5-ADIOL-S may contribute to the synthesis of potent androgens in peripheral tissues, and 3 alpha-DIOL-S could be a marker of androgen metabolism in various female patient groups.
3 citations
,
January 2012 in “Hanyang Medical Reviews” This review discusses the pathogenesis of hirsutism and related diagnostic criteria for polycystic ovary syndrome in Korean women, but reports no new clinical results.
2 citations
,
April 2023 in “BMC endocrine disorders” In this study, a significant positive correlation between clinical hyperandrogenism and free androgen index was found in younger women with PCOS, but not in older women.
1 citations
,
May 2013 in “Journal of the Egyptian Women's Dermatologic Society (Print)” This study found that increased PSA levels in women with hyperandrogenism may serve as a diagnostic marker, comparable to free testosterone levels.
1 citations
,
August 2012 in “Journal der Deutschen Dermatologischen Gesellschaft” A woman's hyperandrogenism was caused by a genetic mutation leading to non-classic adrenogenital syndrome.
1 citations
,
October 2010 in “Cambridge University Press eBooks” This article reviews the diagnosis of hyperandrogenism in PCOS, discussing its clinical and biochemical components, but reports no new clinical results.
1 citations
,
May 1999 in “Journal of The European Academy of Dermatology and Venereology” This article provides guidelines for diagnosing and managing androgenetic alopecia, highlighting that medical treatments like finasteride and minoxidil can effectively halt and reverse the condition's progression in many cases.
February 2025 in “Cureus” This case report describes a 37-year-old female with non-classical congenital adrenal hyperplasia who presented with severe acne, progressive hair loss, and primary infertility, managed with prednisolone.
August 2023 in “Journal of Cosmetic Dermatology” This study observed that in a mouse model of androgenetic alopecia, treatments with LTF, 5% minoxidil, and LTF-DPC-EXO significantly promoted hair regeneration compared to the model group, potentially through modulation of the PI3K/AKT signaling pathway.
Hyperandrogenism is diagnosed using clinical signs, lab tests, and imaging.
June 1995 in “International Journal of Gynecology & Obstetrics” This article provides citations without reporting new findings on androgen conjugate levels in alopecia.
In this review, the authors discuss various skin conditions linked to hyperandrogenism, such as acne and alopecia, with a focus on androgen-targeted therapies, suggesting these are generally more effective than non-androgen-targeted options.
May 2026 in “Endocrine Connections” This review posits that alopecia in PCOS results from the interaction between local follicular signaling failures, insulin resistance, inflammation, and genetic predispositions, rather than solely from androgen excess, and recommends a systems-level framework for its management.
April 2026 in “Russian Journal of Skin and Venereal Diseases” This review reports that hyperandrogenic conditions in women, which affect skin and overall well-being, lack dedicated treatment guidelines, presenting challenges in standardizing care.
March 2026 in “JCEM Case Reports” In this case report, a 71-year-old woman with severe hyperandrogenism and virilization revealed a bilateral ovarian steroid cell tumor, confirmed after adnexectomy, resulting in normalized testosterone levels and improved hirsutism post-surgery.
June 2025 in “General medicine and Clinical Practice” This study found that a lifestyle modification program significantly improved androgenic alopecia, acne vulgaris, and hirsutism levels in infertile overweight and obese women, with 36.2% achieving pregnancy post-intervention compared to none before, suggesting enhanced fertility and reduced hyperandrogenism.