13 citations
,
July 2019 in “Journal of Biochemical and Molecular Toxicology” In this study on rat dermal papilla cells, hydroxytyrosol, an antioxidant found in olive oil, was reported to protect against oxidative stress, reduce inflammation, and enhance hair growth factors, suggesting its potential to prevent hair loss.
12 citations
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November 2024 in “International Journal of Molecular Sciences” This study found that hydroxytyrosol significantly alleviated acute liver injury in mice by suppressing inflammation and targeting the TNF-α/PI3K/AKT signaling pathway.
May 2026 in “International Journal of Molecular Sciences” This study suggests that hydroxytyrosol may influence inflammation and oxidative stress pathways in androgenetic alopecia, particularly through interaction with the PTGS2 gene, warranting further experimental validation.
January 2026 in “Journal of Materials Chemistry B” In this study, researchers developed a delivery system using a deep eutectic solvent to improve hydroxytyrosol absorption for hair regrowth, achieving over threefold greater skin penetration compared to aqueous solutions and demonstrating its effectiveness and biocompatibility in hair regrowth and ROS-scavenging tests.
104 citations
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January 2016 in “Food & Function” This review found that olive oil phenols may have anti-cancer properties in animal models and some human studies, but further research is needed to confirm these effects in humans.
4 citations
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July 2025 in “Cosmetics” This review discusses the potential of olive mill wastewater as a valuable source of dermatological ingredients, highlighting its antioxidant and anti-inflammatory properties, but reports no new clinical results.
August 2025 in “International Journal of Molecular Sciences” This study found that compounds isolated from Osmanthus fragrans var. aurantiacus demonstrated antioxidative and anti-inflammatory activities, potentially offering therapeutic benefits for inflammatory bowel diseases by inhibiting COX-2 and iNOS enzymes and blocking ERK 1/2 MAPK signaling.
May 2025 in “Preprints.org” This review highlights the potential of olive mill wastewater as a sustainable source of cosmeceutical ingredients with antioxidant, anti-inflammatory, and dermatological benefits but reports no new clinical findings.
May 2025 in “Preprints.org” This review discusses the potential of olive mill wastewater as a sustainable source of dermatological ingredients with antioxidant and regenerative properties but reports no new clinical findings.
May 2025 in “Preprints.org” This review discusses the dermatological potential of olive mill wastewater as a sustainable source of high-value cosmeceutical ingredients but reports no new clinical results.
8 citations
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December 2021 in “International Journal of Family Studies, Food Science and Nutrition Health” This review discusses the potential health benefits and applications of extra virgin olive oil as a nutritional therapeutic immune-enhancer, but reports no new clinical findings.
1 citations
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January 2021 in “Elsevier eBooks” This study found that olive and olive oil may significantly reduce cardiovascular disease risk, cholesterol, and blood pressure, while offering antioxidant protection through bioactive metabolites like oleuropein.
12 citations
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May 2015 in “Molecular Medicine Reports” This study demonstrated that troxerutin may protect human dermal papilla cells from H2O2-induced damage and suggests potential in treating alopecia by inhibiting ROS-mediated cellular damage.
November 2022 in “Journal of Investigative Dermatology” This study developed a chalcone-based molecule that significantly increased tyrosinase inhibition and solubility, showing potential as a safe and effective skin depigmenting and antiaging agent, with supportive epigenetic and antioxidant properties observed in vitro.
11 citations
,
June 1979 in “British Journal of Dermatology” This study found that the dehydroepiandrosterone hydroxylating enzyme system in hair follicles is similar to the liver monooxygenase system, sharing characteristics such as inhibition by carbon monoxide and dependency on NADPH.
11 citations
,
January 2017 in “Oxidative medicine and cellular longevity” This study found that antroquinonol inhibited CD8+ T cell proliferation and reduced proinflammatory cytokine secretion in vitro, while also ameliorating H2O2-induced depigmentation and resisting reductions in hair follicle length, skin thickness, and tyrosinase expression in mice.
September 2022 in “The Korean Tea Society” This study identified several active compounds in Houttuynia cordata and found that most demonstrated significant antioxidant and acetylcholinesterase inhibitory activity, potentially useful for developing functional tea products.
January 2017 in “대한본초학회지(본초분과학회지)” This study found that Sinseon-yukza-hwan extract has strong antioxidative properties, effectively inhibiting free radical generation, which supports its potential use as a natural antioxidant.
January 2002 in “HAL (Le Centre pour la Communication Scientifique Directe)” In this study, researchers characterized a dehydroepiandrosterone hydroxylating enzyme system in hair follicles similar to the liver monooxygenase system, noting its inhibition by carbon monoxide and its dependence on NADPH.
75 citations
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January 1980 in “Journal of Investigative Dermatology”
5 citations
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February 2017 in “Biomolecules & Therapeutics” The authors reported that 4-O-methylhonokiol decreased TGF-β1-induced cell cycle arrest and oxidative stress markers in human keratinocyte cells, suggesting a potential protective role in TGF-β1-mediated cell cycle regulation.
6 citations
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December 2020 in “Biological & Pharmaceutical Bulletin” This study found that certain fatty acids and triterpenoid-glycosides from Eclipta prostrata L. leaves exhibit potent inhibitory effects on the protein tyrosine phosphatase 1B enzyme, suggesting potential anti-diabetic and anti-obesity benefits.
2 citations
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April 2021 in “International Journal of Cosmetic Science” This study found that a sunscreen with oxothiazolidine and δ-tocopheryl glucoside provided complementary oxidative protection, with immediate but brief effects from oxothiazolidine and prolonged effects from the slower-absorbing δ-tocopheryl glucoside.
2 citations
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September 2018 in “Walailak Journal of Science and Technology (WJST)” This study found that Thuja orientalis fruits have higher monoterpene, flavonoid, phenolic content, and antioxidant activity than leaves, suggesting potential value for the pharmaceutical industry.
3 citations
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October 1994 in “Journal of Dermatological Science” This study developed a novel monoclonal antibody, TYHF-1, which specifically reacts with hair keratins but not with epidermal keratins or various other tissue cells.
September 2024 in “Journal of Cosmetic Dermatology” This study found that the topical application of DA-OTC-002, a combination of synephrine and tyramine hydrochloride, significantly reduced immediate hair shedding in women by 62.5% compared to a placebo, without any observed adverse effects.
43 citations
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January 2016 in “Oxidative medicine and cellular longevity” This review discusses the biological effects and mechanisms of THSG in antiaging and related disease treatments but reports no new experimental findings.
1 citations
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January 2016 in “Journal of Clinical & Experimental Dermatology Research”
49 citations
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October 2017 in “Nutrients” This study observed that the ethyl acetate extract of Equisetum debile showed high activity against 5α-reductase and lipid peroxidation with no cytotoxicity on dermal papilla cells.
January 2023 in “Applied sciences” This study suggests that Equisetum debile extracts, particularly the ethyl acetate fraction, may offer natural cosmeceutical benefits for treating hyperpigmentation, delaying skin aging, and remediating hair loss due to androgenic alopecia.