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Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Minoxidil effectively treats severe hypertension but has notable side effects.

Honokiol might help reduce male skin aging by maintaining testosterone levels.

African baobab fruit is a good source of antioxidants and micronutrients, but too much can cause laxative effects.

The steroids allopregnanolone and allotetrahydrodeoxycorticosteron worsened absence seizures in rats.

Permanent hair dyes use chemicals that react with hydrogen peroxide to create color.

Black henna tattoos can cause severe allergies to hair and textile dyes, and there's a need for greater public awareness and regulation.

Angiopteris evecta extracts significantly promote hair growth in rabbits.

Many substances, including chemicals and metals, can cause skin reactions; careful handling and identification of allergens are crucial to prevent dermatitis.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

Polysaccharides have many health benefits and are used in drugs, but isolating and purifying them is complex and requires careful methods.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Some medicinal plants can help heal wounds and may lead to new treatments.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

Jasmonic acid and its derivatives play important roles in plant health and have potential uses in medicine and agriculture.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Testosterone may slow down wound healing and increase inflammation.

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Low doses of mixed chemicals cause permanent reproductive malformations in male rats.

Germacrone from Curcuma aeruginosa may help treat conditions related to male hormones by blocking a specific enzyme.

Nano-sized plant-based chemicals could improve cervical cancer treatment by being more effective and causing fewer side effects than current methods.

Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.

Vitamin D3 analogs can promote hair growth in mice genetically prone to hair loss.

New sulfur-containing steroid analogs show promise for more targeted medical treatments.