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This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential for disease treatment, but notes challenges in their clinical application.

This review discusses hydrogel-forming microneedles for non-invasive drug delivery in dermatology and reports no new clinical results, emphasizing their promise in improving treatment adherence and patient comfort.

This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential and challenges for clinical application, but it reports no new clinical findings.

This study found that a microneedle system delivering VEGF and Ritlecitinib improved hair regeneration in mice with androgenetic alopecia, showing faster anagen onset and better hair quality compared to minoxidil.

This review outlines the development, applications, and challenges of microneedle-based drug delivery from 2000-2019, particularly highlighting fabrication techniques, but reports no new clinical results.

This review summarizes recent research on microneedles for alopecia treatment and hair regrowth, noting their potential to improve drug delivery and patient outcomes, but reports no new clinical results.

This review reports that microneedle systems can enhance the delivery and effectiveness of Traditional Chinese Medicine compounds in treating skin disorders, though most findings are based on preclinical studies and face challenges in translating to clinical practice.

In this study, researchers developed a new microneedle patch delivery system for minoxidil, which enhanced its controlled release and improved hair growth in mice, potentially offering better treatment outcomes for androgenetic alopecia.

In this study, chitosan hydrogels and delivery systems showed promise in supporting skin recovery post-laser procedures, enhancing topical treatments for acne and melasma, and improving hair density in scalp applications, but limited study sizes and formulation variability restrict generalizability.

This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.

This review discusses the challenges of traditional phytochemical delivery methods and highlights the potential of microneedles to improve intra/transdermal delivery, reporting no new clinical results.

This study introduced hydrogel microneedles loaded with palladium nanoparticles, which utilize the inherent cytotoxicity of polyethyleneimine to enhance the effectiveness of doxorubicin in treating melanoma, achieving a tumor inhibition rate of up to 98% in a murine model.

This review examines hydrogel microneedles for transdermal drug delivery, discussing their applications and challenges but reports no new clinical results.

This study explored the potential of silk fibroin methacrylate hydrogel microneedles to deliver α-MSH directly to the epidermis in vitiligo patients, enhancing melanocyte protection and melanosome transfer, potentially offering a new treatment avenue for this challenging condition.

This study developed a hydrogel microneedle system combining ginseng-derived exosomes and biomimetic nanoparticles to address oxidative stress, inflammation, and melanocyte deficiency in vitiligo, showing significant repigmentation in mice within 3 weeks by enhancing melanocyte protection and keratinocyte proliferation.

This study developed a novel zinc-releasing hydrogel, Zn-Gel, which promoted wound healing by controlling zinc ion release and demonstrated excellent compatibility and efficacy in enhancing cell proliferation, blood vessel formation, and tissue regeneration in vitro and in vivo settings.

This review examines the potential of swellable microneedles in drug delivery and diagnostics, highlighting innovations and challenges in their use for chronic disease treatment, but noting that issues like physiological responsiveness and long-term stability still require research.

This review discusses various microneedle technologies for long-acting drug delivery, highlighting design considerations and challenges in bringing these minimally invasive devices to market, but it reports no new clinical results.

This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.

In this review, the authors summarized non-pharmacological therapies that may promote hair growth and regeneration as alternatives to traditional drug treatments and hair transplantation, both of which have notable limitations.

This study summarizes the role and potential applications of stem cell exosomes in skin and bone healing, highlighting their regenerative capabilities and suggesting innovative delivery methods like nanoliposomes and hydrogels to improve bioavailability and therapeutic outcomes.

This review discusses the potential of asiaticoside from Centella asiatica for enhancing wound healing after endoscopic submucosal dissection and highlights delivery strategies to improve its gastrointestinal application; it reports no new clinical results.

This study investigated the integration of crystal engineering and microneedle technology for androgenetic alopecia treatment, finding that microneedles loaded with newly developed Kopexil multicomponent crystals reduced drug diffusion rates in vitro compared to standard formulations.

The researchers developed semi-dissolving microneedle patches using TEMPO-oxidized bacterial cellulose nanofibers, which allow effective transdermal drug delivery by forming micro-channels for large drug quantities, overcoming traditional microneedles' low drug loading.

The microneedle arrays effectively promote wound healing and have potential for clinical use.

This review discusses the design, properties, and potential applications of smart microneedles, with no new clinical results presented.

This article reviews recent developments in microneedles combining metallic elements and herbal compounds for wound healing, highlighting their benefits such as enhanced therapeutic efficacy and reduced toxicity, and offering a reference for future advancements in this technology.

This study found that low-molecular-weight hyaluronate significantly improved the mechanical strength and elastic modulus of overbleached hair by enhancing hydrogen bond networks within keratin.

This review reports that biomaterial-based drug delivery systems show promise in overcoming the limitations of traditional therapies for pathological scars by integrating sustained drug release with minimally invasive transdermal technologies, potentially enhancing treatment efficacy for these challenging skin lesions.

This study found that downregulating miR-30a-5p levels inhibits apoptosis and promotes proliferation in hair follicle stem cells, which is associated with the activation of the Wnt/β-catenin signaling pathway.