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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Dextran sulfate was found to be toxic and ineffective for treating HIV.

Taxane chemotherapy can cause skin, hair, and nail side effects, which are often under-reported and can affect patient quality of life.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

Liposomes could improve how skin care products work but are costly and not very stable.

Fullerenes show potential in skin care but need more safety research.

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

Platelet-rich plasma may help in skin and hair treatments, and with muscle and joint healing, but more research is needed to fully understand its benefits and limitations.

Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.

Women with PCOS have fewer activated T cells in their ovarian follicles, which might affect fertility.

People with diabetes or obesity should manage their conditions carefully as they have a higher risk of severe COVID-19.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Platelet preparations generally show positive effects on wound healing and facial rejuvenation, but more thorough research is needed to confirm their effectiveness.

PHBV nanofiber matrices help wounds heal faster when used with hair follicle cells.

Children with atopic dermatitis often have sleep problems due to itching and may benefit from melatonin, which helps with sleep and skin symptoms.

Most patients with chronic kidney disease have skin problems, which get worse as the disease progresses, and dialysis doesn't greatly reduce these issues.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Nanotechnology in dermatology shows promise for better drug delivery and treatment effectiveness but requires more safety research.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.