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Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

The 3D-SeboSkin model effectively simulates Hidradenitis suppurativa and is useful for future research.

The study found that tight junctions reach the top layer of the skin's stratum granulosum, not just the second top layer as previously thought.

Dermal Papilla Cells grown in 3D and with stem cells better mimic natural hair growth conditions than cells grown in 2D.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Regenerative cosmetics can improve skin and hair by reducing wrinkles, healing wounds, and promoting hair growth.

Skin may help in getting rid of excess iron through the process of skin cell renewal.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.

The right cells and signals can potentially lead to scarless wound healing, with a mix of natural and external wound healing controllers possibly being the best way to achieve this.

Faulty LEF1 activation causes faster skin cell differentiation in premature aging syndrome.

Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.

Scientists made structures that look like human hair follicles using stem cells, which could help grow hair without using actual human tissue.

Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.

Nanoparticles can speed up wound healing and deliver drugs effectively but may have potential toxicity risks.

Some systemic treatments work for nail psoriasis but can have serious side effects.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Efficient delivery systems are needed for the clinical use of CRISPR-Cas9 gene editing.

Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.

Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.

Targeting the HEDGEHOG-GLI1 pathway could help treat keloids.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Drug approvals slowed in 2Q22, but notable drugs like Amvuttra, Camzyos, and Olumiant were approved.

Adalimumab is the most effective treatment for severe hidradenitis suppurativa, but more research is needed to improve treatment options.

EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Skin side effects from cancer treatments can lead to changes in therapy and are common, with nail changes being the most frequent.

Understanding drug interactions, side effects, and patient-specific factors is crucial for effective dermatological care.

Cetuximab can cause eyelash growth, which is rare but manageable.

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.