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Over 50% of women over 50 experience hair loss, with minoxidil being the only proven effective treatment.

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

Some skin diseases and their treatments can negatively affect male fertility.

The document emphasizes the importance of correctly identifying and classifying genetic hair disorders to help diagnose related health conditions.

The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.

Frontal Fibrosing Alopecia might be an autoimmune disease.

Testosterone can both promote hair growth and cause baldness by affecting hair growth signals.

Telogen Effluvium is a hair loss condition where treatment involves identifying and managing its triggers.

Male androgenetic alopecia involves hair follicle miniaturization due to DHT, with potential treatments using inhibitors and blockers.

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

The document concludes that permanent hair loss conditions are complex, require early specific treatments, and "secondary permanent alopecias" might be a more accurate term than "secondary cicatricial alopecia."

High aldosterone and free testosterone levels link to female hair loss; testing aldosterone may predict hypertension risk.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

Understanding genetic mutations helps diagnose and treat skin disorders like ichthyosis.

Muscles can make their own androgens, which may help muscle growth.

The over-the-counter supplement DHEA could make COVID-19 worse, especially in diabetics and people with G6PD deficiency.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Hormones like testosterone and estrogen significantly affect hair growth and structure.

Men with male pattern baldness don't necessarily have high levels of Dehydroepyandrosterone-sulfate, and there's no link between its levels and the severity of hair loss.

New treatments for ichthyosis, like protein replacement and gene therapy, show promise and may become standard care.

Zinc pyrithione needs targeted delivery to the scalp for effective dandruff treatment.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

The study developed a method to detect minoxidil and its sulfate form, found that minoxidil sulfate is temperature-sensitive, and identified a way to potentially increase its stability for hair loss treatment.

Men with male-pattern baldness have higher levels of certain testosterone metabolites and may have more active androgen metabolism.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Women with hair loss had higher levels of certain hormones, suggesting a link to a condition like PCOS.

Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.