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The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.

The review says that stem cells are beneficial for making skin replacements.

Innovative methods are reducing animal testing and improving biomedical research.

Different factors like pH, gel type, and chemical enhancers affect how well hydrocortisone gets into hair follicles, and less hydrated skin doesn't work well with the test method.

As skin cells mature, vitamin D receptor levels decrease while retinoid X receptor α levels increase.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Researchers found a safe and effective way to pick genetically modified skin cells with high growth potential using CD24.

Hox genes control hair follicle stem cell regeneration in different body regions.

Glucosylceramides are essential for healthy skin and proper wound healing.

Self-assembling RADA16-I hydrogels with bioactive peptides significantly improve wound healing.

Common skin fungal infections can suggest a weak immune system, and for scalp infections, pills work better than creams, with several drug options available.

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

Scientists can now grow hair-like structures in a lab using special 3D culture systems, which could potentially help people with hair loss or severe burns.

The review suggests that a special cell-derived treatment shows promise for various skin conditions and hair growth but needs more research for confirmation.

Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.

Sweat gland development involves two unique skin cell programs and a temporary skin environment.

Melatonin receptors in hair follicles help regulate hair growth and could treat hair loss.

Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.

ELL is crucial for gene transcription related to skin cell growth.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Boosting HGF signaling could improve the creation of hair follicles in lab-made skin.

Skin RAGE levels are linked to inflammation and cell death.

A microneedle patch can help regrow hair by restoring immune balance in hair follicles.

Thermal spring waters and their microbes could be good for skin health and treating some skin conditions in skincare products.

The model better predicts how water-loving and fat-loving substances move through the skin by including tiny pores and hair follicle paths.

A potential treatment for atopic dermatitis could be to increase PADI1 expression to improve skin barrier function.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Activating c-Myc in skin causes rapid cell growth and changes, but these effects are reversible.

Sphinganine can reduce hair loss and improve scalp health.

A substance from Caulerpa racemosa seaweed may protect against skin damage caused by air pollution by reducing oxidative stress and cell death.