1 citations,
July 2021 in “IntechOpen eBooks” Environmental factors can cause mutations in skin proteins, leading to skin disorders.
35 citations,
June 2012 in “PloS one” Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.
3 citations,
March 2023 in “International journal of molecular sciences” Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.
2 citations,
August 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific mutation in the K25 gene causes a rare genetic disorder with curly hair at birth and later hair loss, along with dental issues.
Researchers made a mouse model with curly hair and hair loss by editing a gene.
5 citations,
August 2011 in “Journal of Dermatological Science” Dentin sialoprotein and phosphophoryn are present in rodent hair follicles and may help hair growth and development.
1 citations,
October 2022 in “Bioengineering” Keratin helps skin cells mature when added to a collagen mix, which could be important for skin and hair health.
9 citations,
August 2021 in “International journal of molecular sciences” PPARγ is essential for maintaining healthy skin, controlling inflammation, and ensuring proper skin barrier function.
2 citations,
November 2017 in “Histochemistry and Cell Biology” Polyamines are abundant in certain parts of rat hair follicles and may play a key role in hair growth.
1 citations,
December 2022 in “Current Issues in Molecular Biology” Annurca apple extract improved hair growth in mice and could potentially prevent hair loss.
1 citations,
November 2022 in “Animals” The research found specific genes and pathways that control fur development and color in young American minks.
1 citations,
June 2016 in “FEBS open bio” Fish oil increased cell growth and macrophages in the skin but didn't affect COX-2 expression.
January 2024 in “Collagen and leather” The conclusion is that using bovine milk permeate to remove wool from sheepskins is eco-friendly and results in smoother, higher quality leather compared to traditional sulfide methods.
October 2023 in “International journal of molecular sciences” Key proteins and pathways regulate wool fiber diameter in Alpine Merino sheep.
235 citations,
July 1999 in “Journal of biological chemistry/The Journal of biological chemistry” Human hair is made up of different keratins, some strong and some weak, with specific types appearing at various stages of hair growth.
Human hair keratins can be turned into useful 3D biomedical scaffolds through a freeze-thaw process.
54 citations,
January 2018 in “Scientific reports” Human hair contains diverse proteins, including keratins and histones, which could help assess hair health and aging.
January 2007 in “The FASEB journal” Human hair keratins help nerve regeneration and support Schwann cell activity.
2 citations,
September 2020 in “Biomedical materials” Recombinant keratin materials may better promote skin cell differentiation than natural keratin.
38 citations,
October 2011 in “Analytical biochemistry” Hair proteins have weak spots in their α-helical segments.
29 citations,
April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
13 citations,
July 2017 in “Biopolymers” Recombinant keratins can form useful structures for medical applications, overcoming natural keratin limitations.
9 citations,
February 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” The document concludes that the human keratin gene cluster is complex, with a need for updated naming to reflect over 50 functional genes important for hair and skin biology.
The research developed a human hair keratin and silver ion hydrogel that could help heal wounds.
October 2023 in “arXiv (Cornell University)” Human hair keratins might be good for filtering out harmful substances like diclofenac and PFBS from water.
19 citations,
July 1994 in “Journal of Dermatological Science” Human hair keratin genes are similar to mouse genes and are specifically expressed in hair follicles.
23 citations,
January 2015 in “Stem cells international” Coating surfaces with human hair keratin improves the growth and consistency of important stem cells for medical use.
138 citations,
March 2007 in “Experimental cell research” Only a few hair-specific keratins are linked to inherited hair disorders.
32 citations,
February 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.
30 citations,
August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” TGase 3 helps build hair structure by forming strong bonds between proteins.