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GlossaryKeratinocytes (Human Epidermal Keratinocytes)

cells in the epidermis that produce protective keratin protein

Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. These cells produce keratin, a protein that helps protect the skin from environmental damage, pathogens, and water loss. They play a crucial role in the skin's barrier function and are involved in wound healing and the formation of hair and nails.

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research Protective Effect of Iris Germanica L. Rhizome-Derived Exosome Against Oxidative-Stress-Induced Cellular Senescence in Human Epidermal Keratinocytes

October 2023 in “Applied sciences”

Iris germanica rhizome-derived exosomes help protect skin cells from oxidative stress and aging.

research Topical SCD-153, A 4-Methyl Itaconate Prodrug, For The Treatment Of Alopecia Areata

2 citations, December 2022 in “PNAS nexus”

SCD-153 shows promise as an effective topical treatment for alopecia areata.

research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.

research Induction of Skin-Derived Precursor Cells from Human Induced Pluripotent Stem Cells

21 citations, December 2016 in “PLOS ONE”

Scientists made skin stem cells from other human cells with over 97% efficiency, which could help treat skin conditions.

research Isolating Subpopulations of Human Epidermal Basal Cells Based on Polyclonal Serum Against Trypsin-Resistant CSPG4 Epitopes

2 citations, December 2016 in “Experimental cell research”

The research found a way to identify and study skin cells with stem cell traits, revealing they behave differently in culture and questioning current stemness assessment methods.

research Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes

77 citations, September 2017 in “Journal of Investigative Dermatology”

TRPV3 in skin cells causes inflammation and cell death.

DermaCult Keratinocyte Expansion Medium: A Serum- and BPE-Free Medium Supporting Long-Term Feeder-Free Expansion of Primary Human Epidermal and Pluripotent Stem Cell-Derived Keratinocytes

research DermaCult Keratinocyte Expansion Medium: A Serum- and BPE-Free Medium Supporting Long-Term Feeder-Free Expansion of Primary Human Epidermal and Pluripotent Stem Cell-Derived Keratinocytes

November 2022 in “Journal of Investigative Dermatology”

DermaCult™ Keratinocyte Expansion Medium allows human skin cells to grow longer while keeping their ability to develop properly.

N,N-Dimethylglycine Sodium Salt Exerts Anti-Inflammatory Effects in Dermatitis Models and Activates Human Epidermal Keratinocytes

research N,N-Dimethylglycine Sodium Salt Exerts Anti-Inflammatory Effects in Dermatitis Models and Activates Human Epidermal Keratinocytes

July 2023 in “International Journal of Molecular Sciences”

N,N-Dimethylglycine Sodium Salt helps reduce skin inflammation and improves skin cell growth and healing.

research Topical Application of Newly Developed Pseudoceramide Improved Both Skin and Hair Barrier Functions

April 2017 in “Journal of Investigative Dermatology”

Applying pseudoceramide improved skin and hair health.

research Development of a Mechanically Stable Human Hair Keratin Film for Cell Culture

3 citations, December 2021 in “Materials today communications”

A new film made from human hair supports skin cell growth better than collagen.

research Interfollicular Epidermal Stem-Like Cells for the Recreation of the Hair Follicle Epithelial Compartment

14 citations, January 2021 in “Stem cell research & therapy”

Human skin cells with stem-like features can help create new hair follicles and sebaceous glands when combined with other cells.

research The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability

28 citations, January 2013 in “Stem cells”

Certain human skin cells marked by CD44 and ALDH are rich in stem cells capable of long-term skin renewal.

Epidermal Wnt/Beta-Catenin Signaling Promotes Dermal Adipocyte Differentiation During Hair Follicle Morphogenesis and Regeneration

research Epidermal Wnt/Beta-Catenin Signaling Promotes Dermal Adipocyte Differentiation During Hair Follicle Morphogenesis and Regeneration

December 2012 in “Journal of Dermatological Science”

Wnt/beta-catenin signaling in the skin helps fat cell development during hair growth and repair.

Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts

research Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts

June 2020 in “Journal of Investigative Dermatology”

Scientists successfully grew mini hair follicles using human skin cells, which could help treat baldness.

research Experiment on the Effect of Artemisia Sieversiana Extract on Hair Loss Prevention and Cell Growth

1 citations, March 2022 in “Daehanhanuihakoeji”

Artemisia sieversiana extract may help prevent hair loss and promote hair growth.

Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation

research Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation

120 citations, August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

Cystine-Thiamin-Containing Hair-Growth Formulation Modulates the Response to UV Radiation in an In Vitro Model for Growth-Limiting Conditions of Human Keratinocytes

research Cystine-Thiamin-Containing Hair-Growth Formulation Modulates the Response to UV Radiation in an In Vitro Model for Growth-Limiting Conditions of Human Keratinocytes

9 citations, September 2018 in “Journal of Photochemistry and Photobiology B-biology”

A hair-growth formula with cystine and thiamin helps protect skin cells against UV damage and improves their growth.

research Translation-Dependent Skin Hyperplasia Promoted by Type 1/17 Inflammation in Psoriasis

April 2023 in “Journal of Investigative Dermatology”

Type 1/17 inflammation in psoriasis increases skin cell growth due to a molecule that could be a new treatment target.

research The Relevance of Collagen XVII Expression in Epidermal Differentiation and Proliferation

September 2016 in “Journal of dermatological science”

Collagen XVII is crucial for skin cell growth and nail health.

Human Hair Follicle Regeneration With Trichogenic Human Dermal Papilla Precursor Cells Derived From Induced Pluripotent Stem Cells

research Human Hair Follicle Regeneration With Trichogenic Human Dermal Papilla Precursor Cells Derived From Induced Pluripotent Stem Cells

April 2017 in “Journal of Investigative Dermatology”

Stem cells can create hair follicles, potentially treating permanent hair loss, and healthy skin and hair depend on mitochondrial function and special fats.

research The Molecular Mechanism of PCE-DP, a Novel Brightening Active Ingredient

September 2019 in “Journal of Investigative Dermatology”

PCE-DP brightens skin and promotes hair growth by enhancing cell growth and reducing melanin uptake.

Saponins of Korean Red Ginseng May Protect Human Skin from Adipokine-Associated Inflammation and Pigmentation Resulting from Particulate Matter Exposure

research Saponins of Korean Red Ginseng May Protect Human Skin from Adipokine-Associated Inflammation and Pigmentation Resulting from Particulate Matter Exposure

4 citations, February 2022 in “Nutrients”

Korean Red Ginseng saponins may protect skin from inflammation and darkening caused by air pollution.

research The Proximal Promoter of the Human Transglutaminase 3 Gene

105 citations, February 1996 in “Journal of biological chemistry/The Journal of biological chemistry”

The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.

research The Simplest Protocol for Rapid and Long-Term Culture of Primary Epidermal Keratinocytes from Human and Mouse

2 citations, January 2019 in “Methods in molecular biology”

A new method helps grow skin cells from humans and mice more easily and quickly.

research Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes

90 citations, February 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Interleukin-1 increases keratin K6 production in skin cells.

research Characterization of the Epidermal-Dermal Junction in hiPSC-Derived Skin Organoids

14 citations, June 2022 in “Stem cell reports”

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

research Epidermal Stem Cells Do Not Communicate Through Gap Junctions

73 citations, January 2002 in “Journal of Investigative Dermatology”

Epidermal stem cells don't use gap junctions to communicate.

$Human Keratinocytes Derived from the Bulge Region of Hair Follicles Are Refractory to Differentiation$