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In this study, hUCMSCs-Exo significantly accelerated wound healing in rat perianal fistulas with notable safety, potentially through the activation of the HIF-1α/TGF-β/Smad signaling pathway.

In this study, human umbilical cord mesenchymal stem cells and their conditioned medium significantly improved symptoms in mouse models of atopic dermatitis, potentially through exosome-dependent pathways, suggesting a cell-free therapeutic strategy.

This study found that exosomes from human umbilical cord mesenchymal stem cells reduced hair follicle aging and promoted hair regeneration in models by upregulating COL17A1 through the miR-21-5p/DKK2/Wnt/β-catenin axis, outperforming existing treatments like minoxidil.

This review discusses the potential of mesenchymal stem/stromal cells and their exosomes in promoting wound healing and skin regeneration, but reports no new experimental results.

This study reviews the roles and mechanisms of MSC-derived exosomes in wound healing, noting their potential as promising cell-free therapies for cutaneous regeneration.

This review article highlights the potential of mesenchymal stem cells, their exosomes, and non-coding RNAs in repairing aging skin tissues due to their ability to secrete beneficial compounds, suggesting their promising role in photoaging treatment without causing immune rejection or granuloma formation.

This review discusses the potential of extracellular vesicles from various sources as promising candidates for hair growth stimulation but notes that clinical trials are needed to confirm their effectiveness and safety.

This study found that mesenchymal stem cells mainly promote skin regeneration and delay aging through paracrine activity, releasing growth factors and cytokines that protect against oxidative stress and stimulate healing.

This review explores how preconditioning mesenchymal stromal cells can impact their secretome's therapeutic potential in regenerative medicine, emphasizing immunomodulatory and regenerative functions, but provides no new clinical results.

This review discusses regenerative medicine approaches for treating alopecia, including mesenchymal stem cell therapies and platelet-rich plasma, but reports no new clinical results, emphasizing the need for further study.

This review found that mesenchymal stem cells and their derived exosomes are a potentially safe and well-tolerated treatment for lung healing in patients with COVID-19.

This study summarizes the role and potential applications of stem cell exosomes in skin and bone healing, highlighting their regenerative capabilities and suggesting innovative delivery methods like nanoliposomes and hydrogels to improve bioavailability and therapeutic outcomes.

This review discusses the potential role of mesenchymal stromal cell-derived exosomes in skin regeneration and calls for more research to address clinical translation challenges, without reporting new results.

This study found that while exosome therapy shows promise for treating AGA, AA, and CIA, its integration into routine practice will depend on rigorous clinical trials and standardized manufacturing and regulatory practices to ensure safety and reproducibility.

In this study, SIRT1-modified human umbilical cord mesenchymal stem cells reduced peritoneal fibrosis in a rodent model, suggesting potential as a treatment strategy for peritoneal dialysis-induced damage.

This review summarizes the mechanisms of mesenchymal stem cell-mediated wound healing and highlights engineering strategies that enhance therapeutic outcomes, but it reports no new clinical results.

This study observed that exosomes from adipose mesenchymal stem cells overexpressing hepatocyte growth factor significantly improved liver function and reduced fibrosis in mice with experimentally induced liver injury.

This study found that umbilical cord mesenchymal stem cell-derived exosomes improved hair growth in mice with androgenetic alopecia by promoting hair follicle stem cell stemness through the RAS/ERK pathway, suggesting a potential new treatment strategy for this condition.

This analysis concluded that mesenchymal stem cell-derived exosome therapy may offer a promising and safe approach for hair restoration, especially in androgenetic alopecia, despite limitations in study consistency and size.

This review discusses recent advances in the therapeutic potential of exosomes for wound healing, highlighting their benefits and challenges but reports no new clinical results.

This review highlights that exosomes from adipose-derived stem cells, particularly those enriched with circ-Ash1l, can inhibit ferroptosis and reduce UVB-induced skin aging by delivering GPX4-promoting signals to damaged cells, thus offering a potential regenerative therapy for photoaged skin.

This review discusses the role and therapeutic potential of mesenchymal cell-derived exosomes in organ development and disease treatment, highlighting their application in cell-free therapeutic strategies and current challenges faced in their use.

This source reviews the role of exosomes in regenerative medicine, highlighting their ability to mediate cell communication and transport biomolecules to enhance or impair biological functions, with potential applications in tissue repair and regeneration.

This review discusses recent research on exosomes' role in dermatology, highlighting their involvement in skin diseases and rejuvenation and exploring therapeutic possibilities in these areas.

This review explores the potential for using exosomes in treating autoimmune skin diseases and promoting skin regeneration, highlighting current applications, delivery methods, and ongoing clinical trials while also identifying challenges and future research directions within dermatology.

In this study, the application of human umbilical cord mesenchymal stem cell secretome significantly increased hair follicle count in fluconazole-induced alopecia in rats, although changes in epidermal thickness were not significant, suggesting a novel approach for hair restoration.

This article reviews how biomaterials and stem cells could advance regenerative medicine but does not report new results, emphasizing the potential of combining novel biomaterials with stem cells for effective therapies.

This review explores the potential of mesenchymal stem cells in skin regeneration and rejuvenation, highlighting their ability to modulate immune response and enhance extracellular matrix strength but does not provide new clinical evidence.

This review discusses strategies to enhance mesenchymal stem cell therapy effectiveness but reports no new clinical results; it highlights the need for improved consistency and efficacy in MSC-based treatments.

This study found that exosomes from human umbilical cord mesenchymal stem cells significantly promoted hair follicle growth and enhanced the transition to the growth phase in a model of androgenetic alopecia, by enriching specific microRNAs that activate key pathways involved in hair regeneration.