24 citations
,
October 2017 in “Scientific reports” This study suggests that controlling light exposure can influence cashmere growth by triggering hair follicles to enter their active growth phase sooner, potentially involving the CSDC2 gene as a key regulator.
21 citations
,
June 2016 in “Genesis” This study identified a gene expression signature in mouse embryonic dermal fibroblasts that depends on Wnt/β-catenin activity, potentially influencing dermal fibroblast identity and function.
20 citations
,
September 2021 in “Nature communications” In this study, researchers identified a gene expression pre-pattern and implicated the Wnt inhibitor Dickkopf 4 in the formation of color patterns in domestic cat embryos.
20 citations
,
June 2010 in “Genes and Immunity” This study found distinct gene expression patterns in the blood of alopecia areata patients, suggesting involvement of immune processes and new pathways like Wnt signaling and apoptosis in disease pathogenesis.
19 citations
,
June 2020 in “Animals” This study found that maternal sub-maintenance nutrition reduced the density and branching ratio of secondary wool follicles in Merino sheep fetuses and identified genes potentially involved in these processes.
18 citations
,
January 2019 in “Animal Biotechnology” This study found that lncRNA-000133 may play a role in secondary hair follicle reconstruction and cashmere fiber growth in goats, potentially through its interaction with the methylation of its regulatory region and dermal papilla cells.
17 citations
,
October 2017 in “Scientific reports” This study found that Super Merino sheep have a higher wool follicle density, finer fleece, and distinct gene expression compared to Small Tail Han sheep, which may inform future breeding and genetic interventions.
16 citations
,
January 2011 in “Archives of Dermatological Research” This study identified 77 genes with significant expression changes in expanded human skin, suggesting possible mechanisms for skin regeneration during tissue expansion, including previously unreported genes like HOXA5, HOXB2, and AP1.
16 citations
,
December 2006 in “Expert Review of Dermatology” This review discusses the multifaceted roles of hair follicles in skin health, including potential contributions to skin neoplasias, and reports no new results.
15 citations
,
December 2014 in “PLoS ONE” This study identifies iRhom2 as a crucial regulator of hair follicle differentiation, showing that the iRhom2Uncv mutation leads to dysplasia and reduced TACE maturation, resulting in a hairless phenotype in mice.
13 citations
,
December 2024 in “Cellular and Molecular Life Sciences” This study reviews recent advancements in understanding caspases, highlighting their roles beyond apoptosis in cancer, inflammation, and neurological disorders, and discusses the potential and challenges of targeting caspases for therapeutic purposes.
13 citations
,
May 2022 in “Cell discovery” This study used single-cell RNA sequencing to create a detailed atlas of human scalp hair follicles and found that early-stage hair graying involves matrix hair progenitor depletion linked to P53 pathway activation.
13 citations
,
June 2020 in “BMC genomics” This study found that chi-miR-30b-5p was more expressed in the telogen phase than in the anagen phase and inhibited dermal papilla cell proliferation by targeting CaMKIIδ.
13 citations
,
March 2020 in “Genes” This study found that FGF5-/- rabbits exhibited a significant long hair phenotype by prolonging the anagen phase, suggesting FGF5 acts as a negative regulator of hair growth.
13 citations
,
November 2013 in “Journal of Endocrinology/Journal of endocrinology” This study found that the vitamin D receptor, but not its ligand, regulates genes involved in hair cycle progression, suggesting a role in integrating hormone signaling pathways for hair and epidermal functions.
12 citations
,
February 2025 in “Scientific Reports” This study found that extracellular vesicles derived from mesenchymal stem cells and umbilical cord blood plasma enhanced wound healing and reduced scar formation in mice, suggesting their potential as therapeutic agents for skin repair.
12 citations
,
April 2014 in “Molecular Medicine Reports” In this study, transcriptome analysis identified 68 differentially expressed miRNAs in human dermal papilla cells treated with hydrogen peroxide, suggesting they play a significant role in growth arrest and apoptosis.
11 citations
,
August 2018 in “Asian-Australasian journal of animal sciences” This study found that a short daily photoperiod increased crude protein digestibility, secondary hair follicle activity, and cashmere quality in Inner Mongolia white cashmere goats without harming fiber characteristics.
11 citations
,
January 2015 in “Skin pharmacology and physiology” In this study, oral collagen peptides increased certain gene expressions related to epidermis development and the hair cycle in hairless mice skin, suggesting potential links to hair health.
11 citations
,
January 2012 in “Journal of cell science” This study demonstrates that Rac1 activity is essential for normal hair follicle formation but influences hair structure and pigmentation, in terminal differentiation, through alterations in hair shaft, cuticle, and pigmentation organization.
10 citations
,
November 2022 in “Protein & Cell” In this study, topical quercetin was found to stimulate hair follicle growth and promote microvascular regrowth in mice, suggesting its potential for hair regrowth strategies.
10 citations
,
December 2021 in “Frontiers in cell and developmental biology” This study used single-cell RNA sequencing to map the cellular composition of sheep hair follicles, revealing differentiation pathways and potential molecular mechanisms for wool curvature, which may inform sheep breeding.
9 citations
,
April 2019 in “Molecules” This study found that a blackcurrant extract with phytoestrogen activity increased hair number and stem cell marker expression in a menopausal rat model, suggesting a potential benefit for hair loss.
9 citations
,
January 2017 in “Elsevier eBooks” This chapter discusses the skin stem cell niche as a complex ecosystem and highlights the diverse components and interactions that influence stem cell function, but it reports no new experimental results.
9 citations
,
January 2015 in “Current problems in dermatology” This review highlights recent genetic research advancements in understanding hereditary hair diseases but reports no new study results, emphasizing the identification of genes related to both monogenic and polygenic hair disorders.
8 citations
,
March 2017 in “Experimental Dermatology” In this exploratory study, researchers found slightly increased levels of inflammatory markers in scalp skin affected by androgenetic alopecia, suggesting differential gene expression involved in hair cycle and keratin production.
8 citations
,
January 2017 in “Stem Cells International” This study found that overexpression of sFRP4 in skin cells reduces Wnt signaling activation, leading to decreased melanocyte differentiation in regenerating hair follicles.
8 citations
,
June 2012 in “PloS one” This study found that the Plcd3(mNab) mutation in mice worsens the alopecia caused by Plcd1 loss, suggesting synergistic effects between Plcd1 and Plcd3 on hair follicle health.
7 citations
,
December 2020 in “Pharmaceutics” In this study, a mixture of tocopherol acetate, L-menthol, and stevioside was more effective in promoting hair growth in mice compared to tocopherol acetate or L-menthol alone.
6 citations
,
November 2017 in “Dermatologic Therapy” In this study, researchers found that applying mometasone furoate 0.1% cream combined with adapalene 0.1% gel resulted in significantly greater hair regrowth over 12 weeks compared to mometasone furoate cream alone in patients with alopecia areata.