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Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

Testosterone therapy can help women with androgen deficiency by improving energy, sex drive, and bone health with few side effects.

Genetic research has advanced our understanding of skin diseases, but complex conditions require an integrative approach for deeper insight.

The document concludes that careful history and physical exams are crucial for accurately diagnosing polycystic ovary syndrome and distinguishing it from other similar conditions.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

The review highlights the need for more research on transgender dermatology, the role of dermatologists in gender affirmation, and the effects of hormone therapy on skin and hair.

Fulvestrant is a well-tolerated new treatment for advanced breast cancer that may delay chemotherapy.

Aging in men is influenced by genetics and lifestyle, leading to muscle loss, bone issues, and skin damage.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Testosterone therapy and surgeries like mastectomy improve transgender men's lives and mental health with low risks and high satisfaction.

The estradiol valerate/dienogest oral contraceptive helps with heavy periods, may improve acne and symptoms in PCOS, and doesn't affect sexual function.

Testosterone replacement may help postmenopausal women with sexual function and bone density, but suitable treatments are limited.

Cyproterone acetate may cause liver cancer at high doses, but is considered safe at recommended doses for approved uses.

Vegetarians should take B vitamin supplements to avoid health issues.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Women with PCOS are more than twice as likely to develop nonalcoholic fatty liver disease.

Women with epilepsy should be monitored for reproductive issues, which can be caused by epilepsy or its treatments, especially when using valproate.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

Hair shedding is an active process that could be targeted to treat hair loss.

Future osteoporosis treatments should focus on increasing bone growth, with many promising options available.

Combining cosmetic procedures with lifestyle changes improves antiaging results.

Baldness in men with prostate cancer is linked to higher levels of certain sex hormones, but chest hair density is not.

Menopause often leads to lower sexual desire and discomfort during sex, but treatment should be personalized and only if it bothers the woman.

Goat skin changes with the seasons due to genes affected by daylight and hormones.

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

PCOS starts in adolescence with hormonal issues, leading to adult health problems, and early treatment is crucial.

Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.

Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.