54 citations
,
September 2013 in “Fertility and Sterility” This study found that discontinuing finasteride led to a significant increase in sperm counts for most men with reduced fertility, though hormone levels and other semen parameters remained unchanged.
3 citations
,
February 2025 in “Journal of the American Academy of Dermatology” This study highlights how sex steroids affect hair growth, reporting that testosterone used in masculinizing hormone therapy can lead to androgenetic alopecia in transgender individuals, while feminizing hormone therapy with estradiol and antiandrogens can reduce hirsutism.
January 2008 in “Yearbook of Endocrinology” Dutasteride and finasteride can change semen and hormone levels in men.
195 citations
,
February 2007 in “The Journal of Clinical Endocrinology and Metabolism” In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.
January 2025 in “HORMONES” This systematic review reported positive outcomes with gender-affirming hormone therapy in Canada and emphasized the urgent need for standardized outcome measurement tools to enhance evidence-based practices.
June 2014 in “The Journal of Urology” This abstract discusses the effects of finasteride on semen and hormone parameters in men with infertility but does not provide new research findings.
10 citations
,
September 2022 in “Indian Journal of Clinical Biochemistry”
68 citations
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February 2019 in “Urology” Hormonal treatment in transgender women reduces semen quality, but stopping treatment may improve it.
15 citations
,
September 2021 in “Frontiers in Endocrinology” This review discusses the impact of gender affirming hormone therapy on cardiovascular outcomes in transgender individuals and reports no new clinical results; the authors underscore the need for more comprehensive studies.
8 citations
,
January 1987 in “Gynecological Endocrinology” This study found that treatment with the pure antiandrogen Flutamide did not affect the estrous cycle or plasma levels of most hormones in female rats, supporting its potential use for treating hirsutism, acne, and alopecia in women.
21 citations
,
October 2009 in “Dermatology” This study found that male pattern hair loss may be associated with differences in serum levels of androstenedione, cortisol, 17 beta-estradiol, and luteinizing hormone, compared to controls.
November 2023 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium” In this study, researchers examined the genetic factors impacting cortisol and DHEA concentrations in the hair of healthy pigs; they found that cortisol levels were heritable and genetically correlated with behavioral stress responses, suggesting these hormones could potentially serve as indicators for selecting disease-resilient pigs.
4 citations
,
January 2019 in “PubMed” This study found that women with female pattern hair loss had significant hormonal imbalances, specifically involving adrenal androgens, suggesting these may play a central role in the condition's development.
2 citations
,
September 2024 in “Journal of Bioscience and Applied Research/Journal of Bioscience and Applied Research ” This study found that vitamin D, calcium, iron, and ferritin significantly correlate with alopecia in both genders, while zinc, B12, folic acid, and TSH correlate only in males.
2 citations
,
February 2023 in “BMC endocrine disorders” This study found that curcumin lowered fasting blood sugar levels and improved menstruation characteristics in women with polycystic ovary syndrome, but it did not affect other metabolic, hormonal, or hirsutism indices.
1 citations
,
March 2022 in “Clinical and Experimental Obstetrics & Gynecology” This study found that in Korean women with polycystic ovary syndrome, higher ovarian volumes were significantly associated with increased serum levels of free testosterone, total testosterone, and 17-alpha-hydroxyprogesterone.
25 citations
,
October 2019 in “Journal of Endocrinological Investigation” This study reported that both drospirenone and chlormadinone acetate oral contraceptives had similar beneficial effects on clinical, metabolic, and hormonal parameters in women with polycystic ovary syndrome over six months.
March 2026 in “Physical Education Health and Social Sciences” In this randomized controlled trial, combining cinnamon and inositol led to significant improvements in metabolic and hormonal parameters, such as reduced LH, testosterone, fasting glucose, and ovarian ultrasound scores, in overweight women with PCOS, indicating superior benefits over either supplement alone.
November 2022 in “International Journal of General Medicine” This study found that non-alcoholic fatty pancreas disease is significantly more prevalent in women with polycystic ovary syndrome, and is associated with metabolic syndrome, insulin resistance, and hyperandrogenism.
June 2020 in “Mağallaẗ al-anbār li-l-ʻulūm al-bayṭariyyaẗ” This study found that finasteride reduced sperm count, motility, and levels of reproductive hormones, indicating negative effects on fertility in albino male rats.
71 citations
,
August 2019 in “The journal of sexual medicine” In this study, transgender adolescents treated with testosterone for a median of 12 months experienced effective virilization, including voice deepening and increased hair growth, but also showed decreased HDL cholesterol and BMD z-scores, and increased hematocrit, with no short-term safety issues reported.
11 citations
,
October 1986 in “International Journal of Gynecology & Obstetrics” This study found that the combination of ethinylestradiol and desogestrel significantly decreased hair growth and hormone levels in hirsute women, suggesting a relationship between hormone changes and treatment effectiveness.
7 citations
,
August 2019 in “Journal of Ovarian Research” This study reported that both phlebotomy and oral contraceptive pills with cyproterone acetate effectively improved insulin resistance and androgenic profiles in women with PCOS, but OCs had more impact on regularizing menstrual cycles.
July 2025 in “Indus journal of bioscience research.” This study found that women with polycystic ovary syndrome showed significant differences in clinical symptoms, hormone levels, and ovarian morphology compared to healthy controls, such as higher body mass index, menstrual irregularities, elevated luteinizing hormone, and polycystic ovarian morphology, suggesting these factors enhance diagnostic accuracy.
May 2023 in “Frontiers in Endocrinology” This study found that tildacerfont treatment in males with congenital adrenal hyperplasia reduced androgen levels and improved markers of testicular function, suggesting potential benefits for male reproductive health.
1 citations
,
January 2016 in “International journal of reproduction, contraception, obstetrics and gynecology” This study found that hypothyroidism in women with PCOS significantly increased insulin resistance and obesity, which might worsen metabolic issues and impact conditions like hair loss and infertility.
August 2022 in “Italian Journal of Animal Science/Italian journal of animal science” This study found that supplementing Angora goats with whole field bean seeds postpartum did not prevent weight and body condition losses but was associated with improved mohair growth and kid weight gain, likely due to better nutrient partitioning towards lactation and hair growth.
This study found that women with polycystic ovary syndrome had significantly higher levels of the protein fetuin-A compared to healthy controls.
8 citations
,
January 2017 in “Fertility and Sterility” This article reviews the impact of aging and related urologic conditions on male fertility, highlighting the effects of various treatments on sperm parameters and recommending pre-treatment counseling for fertility preservation. It reports no new clinical results.
1 citations
,
September 2013 in “Fertility and Sterility” Finasteride discontinuation increases sperm count in men.