December 2023 in “International Journal of Research in Dermatology” This study evaluated hormonal differences in males with early androgenetic alopecia, finding increased serum testosterone, prolactin, LH, LH/FSH, and FAI levels, with decreased FSH and SHBG levels, compared to controls without hair loss.
October 2023 in “ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS” This study found that in women with PCOS, insulin resistance is closely associated with hyperandrogenism, indicating it may independently predict increased androgen levels.
October 2023 in “IntechOpen eBooks” This book chapter reviews the genetic and epigenetic factors influencing PCOS, particularly in a global context and specific to India, and reports no new clinical findings.
October 2023 in “Journal of the Endocrine Society” In this case study, the authors observed that weight loss coupled with a brief use of oral contraceptives was associated with normalized testosterone levels in a woman with severe hyperandrogenism and PCOS.
July 2023 in “Journal of Clinical Medicine” In this study, researchers investigated factors predicting resistance to clomiphene citrate in women with anovulatory PCOS, identifying AMH and SHBG levels as significant indicators, but they found no reliable thresholds for predicting resistance to the standard 50 mg/day dose.
May 2023 in “Frontiers in Endocrinology” This study found that tildacerfont treatment in males with congenital adrenal hyperplasia reduced androgen levels and improved markers of testicular function, suggesting potential benefits for male reproductive health.
November 2022 in “International Journal of General Medicine” This study found that non-alcoholic fatty pancreas disease is significantly more prevalent in women with polycystic ovary syndrome, and is associated with metabolic syndrome, insulin resistance, and hyperandrogenism.
September 2022 in “Biomedicines” This study found that lipid accumulation product (LAP) and free androgen index (FAI) can highly predict liver steatosis in women with PCOS phenotype A.
April 2022 in “Indian Journal of Forensic Medicine & Toxicology” This study found that PSA concentrations in peripheral blood are related to androgen levels, suggesting that PSA is a valuable marker for diagnosing hyperandrogenism in women.
May 2021 in “Journal of the Endocrine Society” This case report describes a 47-year-old woman diagnosed with a rare Sertoliform endometrioid carcinoma of the ovary, emphasizing its early-stage presentation and generally favorable prognosis.
July 2020 in “International journal of clinical & experimental dermatology” In this study, the researchers found that a high percentage of young women with alopecia had deficiencies in Vitamin D, zinc, ferritin, and haemoglobin levels, suggesting the importance of testing these factors in such cases.
March 2020 in “Endocrinology research and practice.” In this study, treating prolactinoma with cabergoline normalized prolactin levels and affected some androgen-related parameters, but did not significantly improve hirsutism in affected women.
This study found that metabolic syndrome is more common in individuals with androgenic alopecia compared to those without, and that free androgen index could help identify those with the syndrome.
May 2019 in “The Journal of Sexual Medicine” This study found no baseline factors that predicted flibanserin efficacy for HSDD, though low testosterone or use of hormonal contraceptives were associated with reduced efficacy.
September 2018 in “Cumhuriyet medical journal” This study found that women with severe hirsutism have thicker subcutaneous abdominal fatty tissue and are more likely to develop metabolic syndrome compared to those with moderate hirsutism.
March 2015 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This article discusses testosterone production in the human body and its effects on muscle mass, bone density, metabolism, and skin, but reports no new findings.
November 2011 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review discusses the role of androgens and estrogens in acne pathogenesis and the potential use of oral contraceptives containing ethinyl estradiol and progestins to manage acne, but reports no new results.
In this study, oral testosterone administered three times daily normalized serum testosterone levels in men with experimentally induced hypogonadism over nine days and significantly reduced SHBG.
January 2011 in “The Journal of Secondary Vocational Education” This study found that isotretinoin treatment in adolescents with nodulocystic acne may lead to changes in adrenal hormone levels, and hirsutism and menstrual irregularity can occur during treatment.
January 2008 in “LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)” This study found that the gene for the enzyme aromatase is expressed in scalp hair follicles of women and is negatively correlated with LH levels, potentially reflecting the hormonal environment of hair follicles in PCOS.
September 2004 in “Fertility and Sterility” Norplant implants lower some androgen levels but don't significantly change sexual function.
This study found that a combination of spironolactone and oral contraceptive pills may improve hirsutism and hormonal profiles in women, although some experienced side effects such as persistent nausea.
September 2002 in “Fertility and sterility” This study found that metformin therapy is associated with the initiation of ovulatory cycles in women with PCOS and a trend toward reduced 17P responses after six months, but did not improve hirsutism or body composition.
July 2002 in “JOGC/Journal of obstetrics and gynaecology Canada” Birth control pills help treat acne, especially when caused by excess male hormones, and are safe to use with antibiotics.
September 2018 in “Fertility and Sterility” In this study, researchers observed that overweight Taiwanese women with PCOS who carry the HSD3B1 1245C allele have a significantly higher risk of developing androgenic alopecia compared to those with the wild-type allele.
May 2017 in “Endocrine Abstracts” This study found that men with early-onset androgenetic alopecia who also met criteria for the male PCOS-equivalent may have impaired gonadal steroidogenesis, suggesting increased risk of future gonadal dysfunction.
July 2015 in “Egyptian Journal of Dermatology and Venereology” This study concluded that patients with androgenetic alopecia may have a higher risk of cardiovascular diseases compared to people without this condition.
This study found that in female androgenetic alopecia, androgen receptors are highly positive in affected areas, supporting their role as regulators of genetically predisposed hair follicles despite normal serum hormone levels.
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March 2008 in “Molecular and Cellular Endocrinology” This review explores the potential (neuro-)endocrine influences on hair follicle epithelial stem cell biology and emphasizes the need for more systematic research, but it provides no new empirical results.
In this study using C3H/HeJ mice, a single subcutaneous injection of the fusion protein PTH-CBD increased anagen hair follicle counts and promoted hair regrowth comparably to daily oral ruxolitinib, potentially by enhancing beta-catenin production and stimulating anagen transition.