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The review highlights the need for more research on transgender dermatology, the role of dermatologists in gender affirmation, and the effects of hormone therapy on skin and hair.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Skin cell-derived vesicles can help heal skin injuries effectively.

Losing 5-10% body weight can improve PCOS symptoms, letrozole is better than clomiphene for fertility, and managing weight and blood sugar is important to reduce pregnancy complications.

Stress from being transgender is linked to higher blood pressure at night and more inflammation, which may affect heart health.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Primary care is key in managing PCOS, focusing on lifestyle changes and medications like birth control and metformin.

Hormonal therapies are safe and effective for treating adult women's acne.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

Combination therapy with oral contraceptives and spironolactone improves hair growth, menstrual issues, and acne in women with PCOS.

The document suggests various treatments for PCOS, including medication for menstrual issues, insulin resistance, and excess hair, as well as fertility treatments, while highlighting the need for personalized care and lifestyle changes.

A breast cancer patient had lasting hair loss after chemotherapy, which improved with minoxidil treatment.

The document concludes that lifestyle changes and medical treatments can significantly reduce symptoms of Hidradenitis Suppurativa, a chronic skin condition.

PRP treatment improves hair density and diameter in women with androgenetic alopecia.

Hormonal imbalances can cause skin and hair problems in women, and treatments that block male hormones can help.

Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Adult female acne is a complex condition that can worsen with menopause, requiring holistic treatment and tailored skincare at different life stages.

The document concludes that non-operative treatment for gender dysphoria is safe and effective, and hormone therapy does not increase cancer risk.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Alopecia is linked to various health and mental conditions, impacts life quality, and needs medical attention beyond its cosmetic effects.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Understanding drug effects and careful monitoring are crucial for safe and effective dermatology treatments.

Future hormone therapy trials should match the diverse needs and priorities of the gender-diverse community.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Adding hormone therapy to radiation improves survival for high-risk prostate cancer recurrence but has side effects.

The document says that early treatment of Acne Vulgaris is important to prevent scarring and that adult onset acne is common in women, often due to hormonal imbalances.

There is no gold standard treatment for hidradenitis suppurativa due to insufficient evidence.