April 2026 in “Microorganisms” This study suggests that Staphylococcus capitis ferment filtrate (SCFF) may promote hair growth and scalp health by modulating pathways related to hair loss, aging, and oxidative stress in vitro.
December 2025 in “Antioxidants” This study reported that fermented yeast complex extract may promote hair regrowth by modulating antioxidative and anti-inflammatory pathways in dermal papilla cells and increasing hair follicle numbers in an animal model.
12 citations
,
February 2017 in “Journal of neuroscience research” This study suggests that extrasynaptic δGABA-A receptors may have a protective role in modulating the severity of catamenial-like seizures by influencing neurosteroid and benzodiazepine responses in mice.
85 citations
,
June 2008 in “Annals of the New York Academy of Sciences” This article proposes a hypothesis that hyperandrogenemia is the final common pathway for developing adolescent PCOS and emphasizes the importance of reducing androgen levels to mitigate risks of metabolic syndrome, diabetes, and infertility in adulthood.
50 citations
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May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses the role of estrogens in hair follicle cycling and the skin, highlighting the need for more research on estrogen signaling pathways and their interactions with other factors in hair biology.
40 citations
,
April 2008 in “European journal of endocrinology” In this study, treatment with insulin sensitizers significantly increased adipose tissue GLUT4 mRNA expression and improved insulin resistance, menstrual patterns, and androgen profiles in PCOS patients, with rosiglitazone being more effective than metformin.
23 citations
,
December 2004 in “Differentiation” This article reviews the interaction between sex hormone pathways and morphogenesis-related signaling in epithelial organ development, using a chicken model to propose testable hypotheses, but reports no new clinical results.
9 citations
,
June 2022 in “Plants” This study found that shallot extract may promote hair growth in androgenetic alopecia by reducing inflammation and modulating gene expression related to key hair growth pathways.
9 citations
,
January 2013 in “PubMed” This abstract suggests that finasteride's suppression of DHT may link DHT to migraine causes, or it may benefit migraines by other finasteride properties like testosterone modulation, but reports no new empirical findings.
7 citations
,
January 2024 in “Medicinska istrazivanja” This review outlines the complexities and varied manifestations of polycystic ovary syndrome, highlighting challenges in diagnosis and management but reports no new clinical findings.
4 citations
,
October 2023 in “Fertility and Sterility” This review highlights potential negative impacts of certain medications on male fertility, such as hormonal disruption and germ cell toxicity, emphasizing the importance of clinicians being aware of these effects to advise on safer alternatives.
1 citations
,
July 2025 in “Functional Foods in Health and Disease” This study found that supplementation with CL22209, a standardized Asparagus racemosus root extract, significantly reduced menopausal symptoms and improved hormonal regulation among early perimenopausal women, with notable improvements in vasomotor and menstrual symptoms compared to placebo, while being safe and well-tolerated over 120 days.
1 citations
,
December 2011 Marine-derived ingredients show potential for hair health but need more human trials to confirm effectiveness.
January 2026 in “International Journal of All Research Education & Scientific Methods” This review highlights recent advancements in understanding and treating alopecia, emphasizing genetic and immune factors involved in different forms, and discusses emerging therapies such as gene-editing and exosome-based treatments, though achieving complete hair regrowth remains a challenge.
January 2026 in “Journal of Cosmetic Dermatology” This study reviewed evidence suggesting that the loss of dermal white adipose tissue (dWAT) during menopause may be linked to decreased estrogen levels, potentially affecting skin health, and discussed non-hormonal treatments, like magnolol, that might help restore dWAT and improve menopausal skin changes.
This study reviews current pharmacological treatments for alopecia, highlighting minoxidil, 5α-reductase inhibitors, JAK inhibitors, and other agents, and notes ongoing research aimed at improving their effectiveness and safety profiles.
This study found that vinegar-processed black soybean and its extract accelerated hair growth and prevented alopecia in mice, with potential mechanisms involving modulation of the Wnt/β-catenin signaling pathway, suggesting they may be promising functional foods for hair regeneration.
May 2025 in “Veterinary Medicine and Science” In this study, oral melatonin given to male Pomeranian dogs with Alopecia X improved semen quality and testicular blood flow in a dose-dependent manner, but altered hormonal balance, indicating complex effects that require further investigation for long-term implications.
April 2025 in “Journal of Investigative Dermatology” This study discovered that exosomes from adipose-derived mesenchymal stem cells can mitigate damage in dermal papilla cells by modulating the TGF-β1/SMAD2 signaling pathway through miRNAs miR-574-3p and miR-125a-5p, revealing potential therapeutic targets for androgenetic alopecia.
43 citations
,
November 2019 in “American Journal of Clinical Dermatology” This review discusses female androgenetic alopecia, highlighting its diagnostic challenges and management strategies, but it reports no new results.
12 citations
,
May 2024 in “Indian Dermatology Online Journal” This study reviewed the role of probiotics in dermatological disorders and suggests they may help treat or prevent inflammatory skin conditions by modulating the microbiota, potentially reducing the need for steroids and antibiotics, though further research is needed to confirm efficacy and safety.
October 2011 in “Dermato-endocrinology” Hormones significantly affect skin health, with vitamin D playing a key role.
November 2015 in “Springer eBooks” Hair loss treated with minoxidil, finasteride, laser/light, hair transplant, and scalp prostheses; more research needed for skin of color.
1 citations
,
June 2019 in “Innovare journal of medical sciences” This review examines the use of natural remedies, including various herbs, for treating polycystic ovary syndrome, but reports no new clinical results.
January 2019 in “Revista Medicina Cutánea Ibero-Latino-Americana” This article reviews the influence of vitamin D on various dermatological diseases and suggests that vitamin D supplementation might aid in maintaining skin cell homeostasis; it reports no new clinical results.
October 2025 in “International Journal of Molecular Sciences” This study found that topical rebamipide, originally a gastric ulcer medication, can activate hair follicle stem cells and promote hair regeneration by modulating dermal adipocyte metabolism, with potential targeting of the prostaglandin E receptor EP4.
109 citations
,
February 2018 in “CB/Current biology” This study concluded that the receptor-like kinase ERULUS, regulated by auxin, is crucial for modulating cell wall composition and pectin dynamics during root hair growth in Arabidopsis.
87 citations
,
March 2015 in “The EMBO Journal” This review discusses the plasticity of stem cell populations and their ability to switch between functions for tissue homeostasis and regeneration, emphasizing environmental and hormonal influences, and reports no new results.
66 citations
,
July 2015 in “Journal of Molecular Biology” This review discusses how macro-environmental factors such as intradermal adipose tissue and sex hormones influence hair and feather stem cell niches, suggesting environmental targets for regenerative medicine, but reports no new clinical results.
56 citations
,
March 2003 in “Journal of Investigative Dermatology” This study found that 17β-estradiol inhibited RANTES production in human keratinocytes by suppressing nuclear factor κB activity, suggesting a potential mechanism for 17β-estradiol's modulation of psoriasis-related inflammation.