16 citations
,
October 2019 in “Biological & Pharmaceutical Bulletin” This study suggests that Houttuynia cordata extract may promote hair growth by stimulating dermal papilla cell proliferation and extending the anagen phase through enhanced energy metabolism and gene expression changes.
14 citations
,
April 2021 in “Biology” This study found that ethanol extract of Tubtim Chumphae rice bran downregulates SRD5A gene expression, similarly to finasteride, suggesting potential use as an anti-hair loss product.
14 citations
,
January 2011 in “Urologia Internationalis” In this animal study, researchers found that finasteride reduced bacterial infection and inflammation in chronic bacterial prostatitis, with the greatest effect when combined with ciprofloxacin.
14 citations
,
December 1998 in “The Journal of Clinical Endocrinology and Metabolism” This study found that MENT is 10 times more potent than testosterone in suppressing gonadotropins and contributing to anabolism in monkeys, with a potentially wider therapeutic index for human androgen replacement and male contraception.
13 citations
,
January 2019 in “Endocrine journal” This study found that transdermal DHT treatment increased penile length in boys with 5α-reductase type 2 deficiency, but post-pubertal growth was limited and carried potential prostate complications.
13 citations
,
January 2017 in “Molecules” This study reported that compounds isolated from Alpinia zerumbet significantly promoted hair cell growth and exhibited anticancer activity in cell cultures, suggesting potential as treatments for alopecia and cancer.
13 citations
,
November 2012 in “PubMed” This study found that in men with sexual dysfunction, use of 5ARI may reduce sexual drive and spontaneous erections without worsening pre-existing erectile or ejaculatory issues.
11 citations
,
September 2012 in “Journal of animal physiology and animal nutrition” This study demonstrated that mink hair growth and pelt quality significantly depend on dietary protein levels and DL-methionine supplementation during the growing-furring period.
11 citations
,
September 1992 in “Journal of pineal research” This study found that repeated immunization against melatonin in Australian feral goats temporarily increased cashmere production and altered growth cycles, but these effects diminished after the first year.
10 citations
,
January 2018 in “Functional Foods in Health and Disease” This study found that berry extracts, especially black raspberry extract, may have anti-aging effects due to their high antioxidant activities.
10 citations
,
November 1997 in “British Journal of Dermatology” This study found that the non-steroidal antiandrogen RU58841 increased hair growth rates and promoted hair cycle initiation in balding human scalp grafts on testosterone-conditioned nude mice, indicating a positive effect on hair growth.
8 citations
,
April 1988 in “Journal of endocrinological investigation” This study found that topically administered spironolactone in healthy volunteers resulted in no detectable systemic absorption or changes in related hormone levels over 72 hours, indicating local effect only.
7 citations
,
August 2020 in “Health and Quality of Life Outcomes” This study found that oral contraceptives containing cyproterone acetate significantly improved the overall quality of life in polycystic ovary syndrome patients after 6 months compared to those containing levonorgestrel.
7 citations
,
June 2020 in “Translational Andrology and Urology” This study evaluated potential penile vascular changes and persistent adverse effects in men discontinuing 5α-reductase inhibitors for androgenic alopecia, but no new clinical results were reported.
7 citations
,
August 2000 in “Journal of Pediatric and Adolescent Gynecology” This review discusses perceptions and side effects of depot medroxyprogesterone acetate and emphasizes the importance of educating teens to enhance compliance; it reports no new clinical findings.
6 citations
,
August 2019 in “PLOS ONE” The researchers reported that Gambogic Amide may prevent hair greying and promote hair growth by maintaining follicle pigmentation in vitro through activation and migration of melanocytes.
6 citations
,
April 2019 in “Journal of Pediatric Endocrinology and Metabolism” In this study, metformin improved BMI, menstrual regularity, and symptoms of hyperandrogenism in adolescents with type 1 diabetes, but did not enhance glycemic control.
6 citations
,
April 2016 in “Journal of the Formosan Medical Association” This study found that metformin treatment improved clinical outcomes in Taiwanese women with polycystic ovary syndrome, notably in overweight and insulin-resistant patients.
6 citations
,
January 2016 in “Evidence-based complementary and alternative medicine” In this study, saw palmetto supplements showed varied effects on cell growth in vitro and did not significantly inhibit growth in the hamster flank organ model despite a notable trend.
6 citations
,
August 1996 in “The Journal of Clinical Endocrinology and Metabolism” MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.
5 citations
,
January 2020 in “in Vivo” This study found that administering testosterone to pregnant rats altered connexin 26 and connexin 43 expression in the uterus, which could disrupt embryo implantation and cause early pregnancy loss.
5 citations
,
March 2019 in “International Journal of Endocrinology” In this study, the combination of exercise and finasteride improved ovarian morphology and hormone levels in rats with polycystic ovary syndrome more effectively than either treatment alone.
5 citations
,
December 2015 in “Asian pacific Journal of Tropical Biomedicine” In this study, the aqueous extract from Phthirusa pyrifolia leaves significantly decreased testosterone levels in male Wistar rats without causing liver or kidney damage, suggesting potential effects on libido and reproduction.
4 citations
,
February 2018 in “Journal of Cosmetic Dermatology” This study found that platelet-rich plasma injections increased hair diameter in the treated Pakistani population, with significant improvements observed in both men and women.
3 citations
,
January 2016 in “Biotechnology and Bioprocess Engineering” This animal study found that Laminaria japonica mixed with insulin-like growth factor-1 significantly promoted hair growth in mice, suggesting its potential use for treating alopecia pending further clinical trials.
2 citations
,
August 2020 in “International Journal of Cosmetic Science” This study suggests that Lindera strychnifolia root extract may help restore a healthy microbial balance on the scalp in men with androgenetic alopecia after 83 days of treatment.
2 citations
,
May 2017 in “International journal of reproduction, contraception, obstetrics and gynecology” In this study, Myoinositol, an insulin sensitizer, was reported to improve menstrual irregularities and skin problems in cases of polycystic ovary syndrome.
1 citations
,
June 2024 in “Archives of Dermatological Research” In this pilot study, researchers found that betulin did not conclusively inhibit hair loss or promote regrowth in patients with hypothyroidism when compared to placebo.
1 citations
,
October 2023 in “PloS one” This study found that testosterone concentrations in hair samples were moderately stable over three months, with cosmetic treatments like coloring increasing testosterone levels, while natural hair color in untreated hair did not affect testosterone measurements.
1 citations
,
April 2020 in “Clinical, Cosmetic and Investigational Dermatology” In this study, topical acyclovir significantly delayed hair growth initiation and completion in mice and reduced hair follicle size, suggesting potential inhibitory effects on hair growth.