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    Glossary Homocysteine

    amino acid linked to cardiovascular risk and hair health

    Homocysteine is an amino acid produced in the body during the metabolism of methionine, an essential amino acid found in many proteins. Elevated levels of homocysteine in the blood can be a risk factor for cardiovascular diseases and are also associated with conditions like alopecia, as high levels can damage blood vessels and affect hair follicle health.

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    1. Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency. PubMed · 1995 · 74 citations
    2. Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria Molecular therapy · 2017 · 29 citations
    3. Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in alopecia areata patients Cutaneous and ocular toxicology · 2012 · 13 citations
    4. Homozygous whole body <i>Cbs</i> knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia ˜The œFASEB journal · 2022 · 7 citations
    5. Mutations in Homocysteine Metabolism Genes Increase Keratin <i>N</i>-Homocysteinylation and Damage in Mice International journal of genomics · 2018 · 5 citations
    6. Evaluation of Serum Homocysteine Levels in Patients with Cutaneous-Oral Lichen Planus and Psoriasis Patients Galen medical journal · 2017 · 3 citations
    7. Spontaneous hair hyperpigmentation in response to vitamin intake in pregnancy—A clue for homocystinuria American Journal of Obstetrics and Gynecology · 1995 · 2 citations
    8. THE IMPACT OF HOMOCYSTEINE IN LUPUS ERYTHEMATOSUS: A LINK OF INFLAMMATION, SKIN AND CARDIOVASCULAR RISK Academic Medical Journal · 2025
    9. Homocysteine in androgenetic alopecia: A case control study and observational experiments on mice Journal of Cosmetic Dermatology · 2024
    10. Comparison of Homocystiene Level in Patients with and without Androgenetic Alopecia Benha Journal of Applied Sciences · 2018
    11. Clinical Utility of Serum Homocysteine for Predicting Insulin Resistance in Women with Polycystic Ovary Syndrome International Journal of Science and Research (IJSR) · 2026
    12. MTHFR C677T Polymorphism and Serum Homocysteine Level as Risk Factors of Coronary Heart Disease in Patients with Androgenetic Alopecia: A Case Control Study The American Journal of the Medical Sciences · 2021
    13. Evaluation of Serum Homocysteine, High-Sensitivity CRP, and RBC Folate in Patients with Alopecia Areata Indian Journal of Dermatology · 2014 · 18 citations
    14. TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network Advanced Science · 2026
    15. The Rotterdam Study: 2012 objectives and design update European Journal of Epidemiology · 2011 · 247 citations
    16. Cystathionine β‐synthase‐deficient mice thrive on a low‐methionine diet ˜The œFASEB journal · 2013 · 28 citations
    17. Evaluation of cardiac risk marker levels in obese and non-obese patients with polycystic ovaries Gynecological Endocrinology · 2016 · 21 citations
    18. Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice Journal of inherited metabolic disease · 2015 · 19 citations
    19. The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice Annals of the New York Academy of Sciences · 2015 · 14 citations
    20. Demethylation of methionine and keratin damage in human hair Amino acids · 2018 · 11 citations
    21. Evaluation of cardiovascular disease risk factors in patients with mycosis fungoides Anais Brasileiros de Dermatologia · 2015 · 6 citations
    22. Cardiovascular risk markers and thyroid status in young Indian women with polycystic ovarian syndrome: A case-control study Journal of Obstetrics and Gynaecology Research · 2014 · 5 citations
    23. Cardiometabolic Risk Factors in Atorvastatin-Treated Women with Euthyroid Autoimmune Thyroiditis Pharmacology · 2023 · 4 citations
    24. Impact of lisinopril on cardiometabolic risk factors in men with hypertension and early-onset androgenetic alopecia Journal of Cardiovascular Pharmacology · 2021 · 2 citations
    25. Delaying treatment in male-pattern hair loss affects the therapeutic response Clinical and Experimental Dermatology · 2010 · 2 citations
    26. Clinical characteristics and factors associated with different BASP subtypes of androgenetic alopecia Frontiers in Medicine · 2026
    27. Successful Remission of Alopecia Areata and Seborrheic Dermatitis in a 21-Year-Old Male via Functional Nutrition and Advanced Diagnostics: A Case Report. PubMed · 2026
    28. The Relationship Between Depression Levels and Suicide Risk in Pediatric Patients with Alopecia Areata and the Oxidant-Antioxidant Balance Turkish Journal of Dermatology · 2025
    29. Red Blood Cells Folate Level in Patients with Alopecia Areata Journal of clinical and investigative dermatology · 2017
    30. Demographic findings of patients diagnosed with pernio and comparison of their vitamin B12, folate and ferritin levels with a control group Turkderm · 2019