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The hair follicle dermal sheath is essential for hair shedding and needs to communicate with the outer root sheath for normal hair growth cycles.

Hair loss patterns differ between males and females due to 5 master regulators and JAK-STAT signaling affects hair growth.

Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.

Exosomes could be a promising way to help repair skin and treat skin disorders.

MOF controls key genes for skin development by regulating mitochondrial and ciliary functions.

Hair proteins have weak spots in their α-helical segments.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Scientists created stem cells that can grow hair and skin.

Small molecule IM boosts hair growth by changing stem cell metabolism.

Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.

Skin heals with scars because only one type of fibroblast is used, not a mix.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Hoxc genes control hair growth through Wnt signaling.

SIRT7 protein is crucial for starting hair growth in mice.

Some traditional Chinese medicines may have anti-aging benefits and could help with hair growth, but more research is needed.

CRISPR/Cas9 has improved precision and control but still faces clinical challenges.

Studying premature aging syndromes helps understand human aging and suggests potential treatments.

The Pemphigus Disease Area Index and Autoimmune Bullous Skin Disorder Intensity Score are the best tools for assessing pemphigus severity.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

The AIRE gene variant rs2075876 is linked to a higher risk of alopecia areata in males.

α-parvin is necessary for skin and hair growth and for the correct orientation of skin cells.

Blocking Wnt/β-catenin signaling with EGF receptor is necessary for proper hair growth.

Cell aging can be both good and bad for tissue repair.