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Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.

Hair follicle stem cells are a promising source for tissue repair and treating skin or hair diseases.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Lamins are vital for cell survival, organ development, and preventing premature aging.

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.

Most hair follicle stem cells do not protect their DNA by dividing it unevenly.

Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

A position effect on the TRPS1 gene causes excessive hair growth in humans and mice.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.

Male pattern baldness is mostly inherited, involves many genes, and is linked to other traits like early puberty and strong bones.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

Testosterone may slow down wound healing and increase inflammation.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Cyclosporin A helps mice grow hair by blocking a specific protein activity in skin cells.

Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.

Older skin has higher cancer risk due to inflammation and stem cell issues.

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Mice without Vitamin D receptors have hair growth problems because of issues in the hedgehog signaling pathway.

Brg1 is crucial for hair growth and skin repair by maintaining stem cells and promoting regeneration.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.