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PBX1 reduces aging and cell death in stem cells by boosting SIRT1 and lowering PARP1.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Increasing PBX1 reduces aging and cell death in hair follicle stem cells by boosting SIRT1 and lowering PARP1 activity.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Asiasari radix extract may be a potential treatment for melanoma because it selectively triggers cell death in melanoma cells by affecting p53 regulation.

Targeting NCoR1 can help treat heart enlargement and dysfunction.

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

The vitamin D receptor helps regulate skin and hair health independently of its usual vitamin D ligand.

The modified wash test is better than TrichoScan® for diagnosing hair loss.

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.

Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

Vitamin D receptor helps control hair growth genes in skin cells.

Only minoxidil and finasteride are FDA-approved for hair loss, with other treatments available but less effective or with side effects.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.

Nano-sized plant-based chemicals could improve cervical cancer treatment by being more effective and causing fewer side effects than current methods.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

The unique coat of lykoi cats is likely caused by new variants in the Hairless gene.