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This study found that glucose metabolism supports hair inductive gene expression and hair shaft elongation in dermal papilla cells, suggesting potential applications for in vitro hair follicle generation.

This study found that deleting the Mof gene in mouse skin leads to severe defects in skin cell self-renewal, differentiation, and hair follicle growth, indicating that MOF is crucial for mitochondrial and ciliary gene expression and essential for skin development.

This study found that conditional deletion of Mof in mice resulted in severe defects in skin development, including compromised epidermal differentiation and hair growth, leading to perinatal lethality.

This study found that Myc activation in epidermal stem cells leads to chromatin modifications that promote stem cell exit and differentiation, which can be influenced by HDAC inhibitors like trichostatin A.

This study reported that in a mouse tail wound model, the synthetic dual inhibitor corin accelerated wound closure by enhancing re-epithelialization, and further in vitro experiments demonstrated increased expression of genes promoting keratinocyte migration, suggesting its potential as a treatment for chronic wounds.

This review examines the role of Epigallocatechin Gallate in aging epigenetics but reports no new research findings.

This study found that periodic red light exposure increased histone acetylation and activated metabolic processes in aged mice, leading to enhanced fatty acid oxidation and the mitigation of cellular aging by influencing gene expression and metabolic regulation.

In a dermal Gorab knockout mouse model, this study found that Gorab mutations increase P53 protein accumulation and disrupt extracellular matrix expression, contributing to accelerated skin aging and suggesting a pathway involving epigenetic regulation.

This study found that targeting the p300/androgen receptor axis effectively reduced AR activation and ovarian fibrosis in mouse models of polycystic ovary syndrome, suggesting a potential therapeutic approach.

The researchers proposed that an epigenetic change in brain androgen receptors caused by finasteride could lead to post finasteride syndrome, while trazodone might reverse this effect by altering the epigenetic expression related to erection and libido.

This study found that a single 8Gy dose of superficial 50kV X-ray radiation minimizes keloid recurrence after excision, and identified genomic pathways and potential molecular targets for improved keloid therapy.

This study found that TSA restored the hair-inductive capacity of skin-derived precursors in mice by enhancing BMP gene expression and signaling through histone acetylation.

This study found that inhibiting class I histone deacetylases in postnatal mouse dermal cells preserved their ability to induce hair follicles during culture by increasing specific gene expressions and activating the Wnt signaling pathway.

This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.

This study found that DNA methylation and histone modification status were altered in peripheral blood mononuclear cells of patients with alopecia areata, suggesting these changes may contribute to the disease's pathological immune responses.

This study explores the correlation between sirtuins' expression, histone deacetylation, and redox status in young and old monozygotic twins to understand their role in age-related mechanisms.

This study found that sustained intracellular acidosis in mice was associated with shortened lifespan, early aging signs, and impaired autophagy.

In this study, researchers found that the histone demethylase UTX is crucial for regulating skin differentiation through retinoic acid signaling, mainly impacting females, as males compensate with a Y-linked paralog.

This review discusses the role of histone marks in the transition between quiescence and proliferation in cells, and reports no new findings, emphasizing the potential existence of a histone "code" for quiescence.

This study found that HDAC6 plays a crucial role in regulating primordial follicle activation, with its overexpression delaying activation and preserving fertility by reducing NGF levels.

This study found that periodic red light exposure in aged mice increased histone acetylation and activated metabolic processes in keratinocytes, mitigating cellular aging through enhanced fatty acid oxidation and altered gene expression related to lipid metabolism.

In this study, periodic exposure to red light in aged mice led to increased histone acetylation and activated mitochondrial fatty acid oxidation, which collectively mitigated cellular aging by modulating metabolism, inflammation, and gene expression.

This research found that inhibiting HSP90 in a murine model increased cellular plasticity, suggesting a potential role for HSP90 in cancer progression through enhanced adaptability to stress.

This review discusses the biochemical and biological functions of histone demethylases and their potential involvement in human diseases, including cancer, but reports no new findings.

This study found that reducing HDAC1 activity in the skin of mice led to defects in hair follicle structure and pigmentation, highlighting HDAC's role in skin and hair maintenance.

This review highlights the crucial role of histone modification in the pathogenesis and treatment of chronic inflammatory skin diseases, and explores therapeutic strategies targeting these epigenetic changes to improve management of conditions such as psoriasis and atopic dermatitis.

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.

This study found that polycomb-group-mediated repression plays a key role in regulating hair follicle stem cell states and lineage progression by distinct mechanisms in adult mouse skin.

This review examines how epigenetic dysregulation affects adult stem cell function, noting that impacts range from minor to serious disruptions in tissue homeostasis and potential cancer development.