908 citations
,
July 2015 in “British Journal of Dermatology” This article reviews the cellular and molecular processes of acute and chronic wound healing, emphasizing the need for collaboration between researchers and clinicians to advance therapeutic solutions; it presents no new clinical results.
318 citations
,
January 2022 in “Signal Transduction and Targeted Therapy” This study systematically reviews the Wnt/β-catenin signaling pathway, discussing its origin, composition, function, involvement in tumors and diseases, and the development of small-molecular compounds targeting this pathway for disease treatment.
255 citations
,
September 2016 in “Frontiers in plant science” This article reviews recent insights into the regulatory role of reactive oxygen species in plant development, highlighting that their mechanisms and signaling pathways remain partially understood.
229 citations
,
May 2006 in “Journal of Experimental Botany” This review highlights the role of reactive oxygen species in root hair growth and cell expansion in plants but does not report new empirical findings.
158 citations
,
February 2012 in “Journal of Investigative Dermatology” FGF18 helps keep hair in its resting phase, affecting hair growth cycles.
128 citations
,
October 2011 in “Development” This study found that adult mouse dermis can be reprogrammed by epidermal cues to resemble neonatal dermis, with changes in fibroblast proliferation and extracellular matrix composition.
101 citations
,
November 2019 in “The Plant Cell” This study found that the zinc finger protein AtZP1 inhibits root hair initiation and elongation in Arabidopsis by suppressing key transcription factors involved in root hair development.
93 citations
,
July 2006 in “Journal of Investigative Dermatology” This study describes the expression patterns of type I inner root sheath keratin proteins K25–K28 in human hair follicles, highlighting their distinct distribution within different layers.
86 citations
,
February 2012 in “Journal of Clinical Investigation” This review discusses recent advances in understanding hair follicle stem cell dynamics and interactions, but it reports no new experimental findings.
65 citations
,
November 2013 in “The EMBO Journal” HDAC1 is crucial for skin development and preventing tumors.
63 citations
,
May 2015 in “PloS one” This study found that GALT5 and GALT2 are redundant enzymes essential for O-glycosylation of AGPs, with mutations leading to significant growth and development defects in plants.
57 citations
,
October 2021 in “Journal of ethnopharmacology” This review compiled by the authors emphasizes the traditional use of medicinal plants for dermatological disorders in India, highlighting the need for further scientific studies to validate their effectiveness and suggesting potential for drug development based on ethnodermatological practices.
35 citations
,
January 2011 in “Journal of Biological Chemistry” This study found that overexpression of sPLA2-X in mice was associated with alopecia and hair follicle abnormalities, highlighting its potential role in hair follicle homeostasis.
13 citations
,
December 2017 in “Stem cells” This study found that in mice, low-dose irradiation causes stem cells in hair follicles to undergo chromatin alterations, which may eventually lead to long-term functional loss in tissues or organs.
10 citations
,
March 2024 in “Endocrine Reviews” In this retrospective review, the author discusses key discoveries in understanding androgen excess disorders like PCOS, focusing on genetic and molecular insights gained from 1965 to 2015.
10 citations
,
July 2023 in “Pharmaceuticals” This study explored the wound healing potential of a natural marine soft coral-derived nanoparticle-based gel in a diabetic excision wound model, finding it effectively regulates proinflammatory cytokines and inhibits enzymes related to wound healing.
10 citations
,
July 2022 in “Dermatology and Therapy” This review discusses the pathogenesis of melasma, including genetic, environmental, and hormonal factors, and highlights potential avenues for new treatments and preventive strategies, but reports no new experimental findings.
10 citations
,
June 2021 in “EMBO reports” This study found that in skin blister healing, hair follicle development is compromised as stem cells repair wounds at the expense of morphogenesis gene expression.
10 citations
,
April 2020 in “PloS one” This study found that mitochondrial dysfunction due to Crif1 deficiency in hair follicle stem cells significantly slows the hair growth cycle in adult mice but does not impact the maintenance of HFSC populations.
9 citations
,
October 2017 in “Frontiers in plant science” This study found that the peach gene CTG134 mediates auxin-ethylene crosstalk, affecting root hair growth and hormone-regulated processes in plants.
9 citations
,
September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” In this study, researchers found that the matriptase-HGF-c-MET pathway may be activated in proliferative cells of human hair follicles and sebaceous glands, suggesting a potential role in hair growth regulation.
7 citations
,
September 2024 in “PLANT PHYSIOLOGY” This study in Arabidopsis thaliana found that exposure to volatile compounds from Penicillium aurantiogriseum promotes root hair growth through signaling involving RALF22, ethylene, auxin, and photosynthesis, and that RALF22 plays a crucial role in the plants' response to these compounds.
7 citations
,
January 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study shows that NIPP1 deficiency in mouse epidermis leads to hyperproliferation, hair loss, and chronic skin inflammation, which can be partially alleviated by dexamethasone treatment.
7 citations
,
November 2016 in “Oncotarget” This study found that Lgr6+ stem cells in mice are not major initiators of UV- or chemically induced skin tumors.
2 citations
,
July 2023 in “Cosmetics” In this study, researchers highlighted that while hair lipids are crucial for hair health and protection, surfactants in shampoos and conditioners can partially remove these lipids, potentially affecting hair structure, though the exact mechanisms remain poorly understood and require further investigation.
1 citations
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December 2023 in “JAAD International” Mast cells may significantly contribute to central centrifugal cicatricial alopecia.
1 citations
,
April 2023 in “Animals” In this study, Min pigs were found to have unique characteristics for secondary hair growth compared to Berkshire and Yorkshire pigs, with the Wnt and BMP signaling pathways stimulating follicle stem cell activity and promoting secondary hair growth and gene expression.
1 citations
,
December 2022 in “Plants” This study suggests that CSLD1 is key to nitrogen-dependent root hair elongation and regulation of AMT1;2 expression in rice roots.
March 2026 in “Preprints.org” In this study, plerixafor was found to enhance melanogenesis and promote repigmentation by engaging a β-arrestin–β-catenin–MITF signaling axis in melanocytes, and showed effectiveness in restoring depigmentation in a murine model without causing systemic toxicity.
This source reviews current understanding of fibroblast lineage differentiation and its role in wound healing, highlighting the potential to reprogram adult cells for scar-free repair by emulating fetal-like regenerative states.