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The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

PGD2 stops hair growth and is higher in bald men with AGA.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Eating disorders like anorexia and bulimia cause skin problems, and dermatologists can help detect these disorders early for better treatment outcomes.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

ICG-enhanced NIR laser therapy may be a promising acne treatment with improvement and no side effects.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

A genetic region near the PAX1 gene is linked to a higher risk of scoliosis in females.

Restoring hair bulb immune privilege is crucial for managing alopecia areata.

Fullerenes show potential in skin care but need more safety research.

Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.