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Hormone therapy can improve mental health and quality of life for people with gender dysphoria, but long-term effects need more research.

Oral estradiol works for many transgender women but needs personalized dosing and monitoring.

ATP-sensitive K+ channel subunits, particularly Sur2A, play a significant role in various cancers.

Spironolactone is safe for treating female hair loss, but the safety of other drugs is uncertain.

Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.

Melatonin affects skin and hair color and protects skin cells, with potential benefits for hair growth and skin health.

5 alpha-reductase inhibitors like finasteride may lower prostate cancer risk and improve cancer screening.

Acyzol could help treat conditions caused by zinc deficiency.

The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.

More research is needed to understand how testosterone is maintained in adult males.

Castration and finasteride lower urinary oxalate in male rats, potentially treating urolithiasis.

The conclusion is that lifestyle changes and weight loss are first-line treatments for infertility due to anovulation, with various medications and assisted reproductive technologies as additional options.

Formestane is a preferred second-line treatment for advanced breast cancer in postmenopausal women because it's effective and has fewer side effects.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Scalp cooling can help prevent chemotherapy-induced hair loss with a 50-90% success rate and is safe for patients.

Testosterone therapy can help improve mood, sexual function, and bone health in women with low androgen levels, but more research is needed to establish safe and effective guidelines.

Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.

Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.

Good nutrition is crucial for health and preventing disease, and supplements can help prevent nutrient deficiencies.

The document says that early treatment of Acne Vulgaris is important to prevent scarring and that adult onset acne is common in women, often due to hormonal imbalances.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

Melatonin helps regulate hair growth and protects the hair follicle from stress.