75 citations
,
January 2014 in “Korean Journal of Urology” This review discusses the adverse effects of 5α-reductase inhibitors, finasteride and dutasteride, on sexual, psychological, and vascular health, emphasizing the need for physicians to inform patients of these risks.
71 citations
,
June 2006 in “Human Reproduction” This study found that in young Taiwanese women with PCOS, low sex hormone-binding globulin levels were associated with low HDL cholesterol levels, independent of insulin resistance and obesity.
65 citations
,
January 2017 in “Postępy Dermatologii i Alergologii” This review highlights the increasing clinical applications of high-frequency ultrasonography in dermatology, particularly for assessing the depth of skin tumors and monitoring inflammatory skin diseases, but reports no new clinical results.
63 citations
,
May 2020 in “Advanced Healthcare Materials” In animal models, this study reported that a wound dressing combining quaternized chitin and silk fibroin significantly enhanced vascular reconstruction and hair follicle regeneration, approaching normal tissue levels.
62 citations
,
January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified 16 novel high sulfur KAP genes and two KAP pseudogenes on chromosome 21q23, showing expression in a specific region of the hair fiber cuticle.
61 citations
,
October 1996 in “Development” This study found that combining adult germinative epidermal cells with non-inductive dermal cells can stimulate hair follicle neogenesis, effectively altering the cells' status to enhance induction.
59 citations
,
March 2013 in “European Journal of Obstetrics & Gynecology and Reproductive Biology” This study found that the prevalence of autoimmune thyroiditis was significantly higher in Italian patients with polycystic ovary syndrome compared to controls, suggesting that these patients should be screened for the condition.
56 citations
,
February 2013 in “International Journal of Molecular Medicine” This study found that human hair follicle-derived mesenchymal stem cells maintained their proliferation and differentiation potential when cultured with acidic fibroblast growth factor, basic fibroblast growth factor, or epidermal growth factor.
51 citations
,
May 2021 in “Nature Communications” This study found that ablating centrosomes in developing epidermis alters keratinocyte division without majorly affecting differentiation, suggesting early epidermal development is driven by high proliferation and cell delamination.
49 citations
,
December 2017 in “Journal of pharmaceutical and biomedical analysis” This study developed and validated a high-resolution mass spectrometry method to screen for prohibited substances and analyze six endogenous steroids in urine according to World Antidoping Agency requirements, demonstrating its effectiveness for antidoping analysis.
48 citations
,
November 2002 in “Journal of biological chemistry/The Journal of biological chemistry” In this study, researchers found that size polymorphisms in certain hKAP1 genes are linked to the hKAP1.1B and hKAP1.3 genes, arising from intragenic deletions and duplications in Japanese and Caucasian populations.
46 citations
,
October 2018 in “JCI insight” In this study, the researchers found that treatment with the JAK inhibitor tofacitinib in alopecia areata patients may reduce clonal CD8+ T cell expansions but does not eliminate them entirely, which could contribute to disease relapse.
46 citations
,
June 2013 in “Journal of structural biology” This study suggests that the mechanical robustness of hair may be enhanced by the binding interactions of keratin-associated proteins, particularly KAP8.1, with intermediate filament proteins.
45 citations
,
June 2008 in “Journal of pharmaceutical and biomedical analysis” This study developed a new HPLC method for detecting prohibited substances like minoxidil and hydrocortisone in cosmetic products, achieving high sensitivity and successful application to real-world samples.
45 citations
,
August 1994 in “Journal of Chromatography B: Biomedical Sciences and Applications” Method detects finasteride in plasma and semen with high sensitivity and accuracy.
39 citations
,
January 2012 in “Dermatology” In this study, the combination of pulse intravenous corticosteroids and methotrexate was associated with positive hair regrowth in severe alopecia areata patients, with half achieving total regrowth.
39 citations
,
January 2006 in “Journal of Cosmetic and Laser Therapy” This study found that pneumatic skin flattening (PSF) significantly reduces pain and post-treatment erythema during high-energy IPL and laser hair removal while enhancing treatment efficacy.
36 citations
,
January 1993 in “Gut” In this study, a high daily dose of interferon alfa-2b administered initially six times a week for two weeks followed by thrice weekly for 12 weeks was most effective in sustaining normal ALT values in patients.
34 citations
,
January 2016 in “Analytical Chemistry” This study reports that a new DART-HRMS method can effectively analyze intact hair for drug use timelines, with cocaine detection aligning with forensic standards and identifying multiple drugs from high-resolution data.
33 citations
,
December 2017 in “Saudi Journal of Biological Sciences” In this study, researchers found that microRNAs in the oar-let-7 and oar-miR-200 families were significantly up-regulated during critical fetal periods of cashmere goat hair follicle development, suggesting their role in this process.
32 citations
,
November 2004 in “Journal of pharmaceutical sciences” This study quantifies the follicular uptake of tea tree oil in bovine udder skin, with microemulsion showing the highest concentration among different formulations tested.
31 citations
,
August 2023 in “Cell Genomics” This study produced a high-coverage genome of the Tyrolean Iceman, revealing no Steppe-related ancestry but significant Anatolian-farmer-related ancestry, and found genetic markers associated with darker skin, male-pattern baldness, type 2 diabetes, and obesity, aligning with observations of his mummified body.
29 citations
,
June 2017 in “Journal of Inherited Metabolic Disease” This review discusses the potential of using high-throughput and high-content screening methods for drug repositioning in rare diseases and reports no new results.
29 citations
,
February 1996 in “Journal of Chromatography B: Biomedical Sciences and Applications” This study developed a fully automated HPLC method for accurately quantifying finasteride in human plasma, achieving a detection limit of 1 ng/ml with validated application in pharmacokinetic studies.
27 citations
,
August 2018 in “Frontiers in Plant Science” This study found that root hair growth is influenced by a complex interplay of auxin, inorganic phosphate, and transcription factors RSL2/RSL4, with reactive oxygen species playing a key role in this regulation.
26 citations
,
November 2016 in “European Journal of Clinical Pharmacology” This study found that using valproic acid during radiotherapy for glioma was associated with delayed hair loss and improved survival outcomes.
26 citations
,
June 2014 in “Fertility and Sterility” In this study, normal weight adolescents with PCOS showed increased insulin resistance and significantly lower levels of high molecular weight adiponectin compared to controls, despite no other metabolic differences.
24 citations
,
November 1997 in “Journal of Biological Chemistry” This study found that genes encoding mouse high-glycine/tyrosine proteins show distinct spatial and temporal expression patterns in hair follicles, suggesting diverse protein distribution during hair growth cycles.
21 citations
,
September 2019 in “Archives of Physiology and Biochemistry” In this study, HIIT increased adiponectin levels and improved cholesterol profiles in women with PCOS, but did not change leptin or vaspin levels.
21 citations
,
August 2014 in “Gynecological Endocrinology” In this study, hs-CRP levels were not significantly associated with PCOS among Indian adolescent women, but showed a positive correlation with body mass index.