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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

The Rotterdam Study aims to understand various diseases in older adults.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Women with PCOS are more likely to have impaired glucose tolerance and type 2 diabetes, especially if they are Asian or obese.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Women with PCOS have heart-related issues not because of obesity, but due to insulin resistance and low adiponectin levels.

Modern science supports the use of some Ayurvedic plants for health, as ancient practices suggested.

Skin problems are very common in people with systemic lupus erythematosus and important for diagnosis.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

JAK inhibitors help with skin conditions but need more research on dosing and safety.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Hair loss linked to higher heart disease risk in both men and women.

DHT may increase the risk of heart disease and death in elderly men.

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

Testosterone replacement may help some postmenopausal women with symptoms like fatigue and low libido, but more research is needed to fully understand its effects.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Metformin improves hair growth and menstrual frequency in women with PCOS and hirsutism.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

Coats' Plus is a genetic disorder with eye abnormalities, brain calcification, poor growth, bone and skin issues, and movement disorders.

White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.

New treatments for male hypogonadism are effective and should be personalized.