22 citations
,
June 2017 in “Advances in Clinical and Experimental Medicine” This review discusses the historical understanding and evolving diagnostic criteria for polycystic ovary syndrome without presenting new clinical findings, highlighting the multifactorial nature and associated risks of the condition.
22 citations
,
December 2016 in “PloS one” In this study, researchers found that the EDMTFH protein is present in specific layers of the chicken embryo skin and feathers, suggesting its role in feather mechanics and development.
22 citations
,
November 2016 in “Indian Journal of Pharmaceutical Education and Research” This study found that ethanolic leaves extract of Hibiscus rosa-sinensis L. exhibited strong antioxidant activity and enhanced wound healing properties in mice, showing reasonable safety in toxicological evaluations without severe alterations.
22 citations
,
August 2011 in “Endocrine Practice” This review discusses the etiology, diagnosis, and management strategies for hirsutism, noting that serious underlying disorders are rare and emphasizing targeted treatment to manage testosterone's effects.
22 citations
,
February 2002 in “Clinics in Geriatric Medicine” This review discusses the biology of hair follicles and common hair disorders in the elderly but reports no new clinical results.
22 citations
,
March 2000 in “Clinical endocrinology” This study found that while ethinyl oestradiol and cyproterone acetate effectively treated hirsutism in 90% of patients, 80% experienced relapse within six months after stopping treatment, suggesting long-term use is necessary.
22 citations
,
September 1994 in “The Journal of Clinical Endocrinology and Metabolism” This study found that three months of oral finasteride treatment significantly decreased dihydrotestosterone levels and hair growth in hirsute women without negatively affecting gonadotropin secretion.
21 citations
,
September 2019 in “Archives of Physiology and Biochemistry” In this study, HIIT increased adiponectin levels and improved cholesterol profiles in women with PCOS, but did not change leptin or vaspin levels.
21 citations
,
August 2014 in “Gynecological Endocrinology” In this study, hs-CRP levels were not significantly associated with PCOS among Indian adolescent women, but showed a positive correlation with body mass index.
21 citations
,
October 2010 in “Encyclopedia of Life Sciences” This article discusses the use of histoculture in cancer treatment, hair growth studies, and immune response research, but reports no new clinical results.
21 citations
,
April 2004 in “Australasian Journal of Dermatology” This report describes a rare case of hair and nail ectodermal dysplasia in a 3-year-old girl, where treatment with topical minoxidil resulted in minimal improvement after 12 months.
21 citations
,
March 2002 in “PubMed” This study found that monthly high-dose steroid pulse therapy for approximately six months was effective and well-tolerated in Taiwanese patients with severe multifocal alopecia areata.
21 citations
,
December 1997 in “The Journal of Dermatology” In this case report, a 57-year-old Japanese woman with alopecia areata, associated with myasthenia gravis and thymoma, showed significant improvement after undergoing thymectomy and receiving high doses of glucocorticosteroids.
21 citations
,
March 1982 in “JAMA” This study found that spironolactone at 200 mg/day effectively reduced facial hair growth in women with moderate to severe hirsutism, with improvements observed within two months and sustained over one year.
20 citations
,
January 2019 in “Frontiers of Hormone Research” This paper reviews the endocrinological aspects of hirsutism, focusing on the role of androgens in excessive hair growth and the related disorders, without presenting new findings.
20 citations
,
January 2012 in “International Journal of Trichology” This study identified polycystic ovarian syndrome as the most common cause of hirsutism among patients and found a positive correlation between hirsutism severity and free testosterone levels.
20 citations
,
April 2002 in “PubMed” In this study, mini rats with reduced growth hormone and insulin-like growth factor-1 levels exhibited distinct differences in skin thickness and hair cycle compared to standard Wistar rats, suggesting potential use as an animal model for studying GH deficiency-related skin conditions.
20 citations
,
December 1994 in “Fertility and sterility” In this study, treatment with flutamide combined with a low-dose oral contraceptive significantly improved hirsutism in women with polycystic ovarian disease who did not respond to oral contraceptive treatment alone.
20 citations
,
May 1990 in “Cleveland Clinic journal of medicine” This study suggests spironolactone, particularly when combined with an oral contraceptive or dexamethasone, may reduce hair symptoms in women with hirsutism, but it should be avoided during pregnancy and in women with a family history of breast cancer.
20 citations
,
August 1987 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” This study suggests that Aldactone may be more effective than Diane in reducing hair growth, despite having minimal impact on hormone levels.
20 citations
,
February 1977 in “The anatomical record” This study found that excess vitamin A in organ cultures of mouse embryos led to significant changes in epidermis and hair follicles, altering morphogenesis and polysaccharide distribution.
19 citations
,
January 2021 in “Experimental dermatology” This study found that acne inversa is primarily an epithelial-driven disease, with cyst-forming tendrils causing inflammation due to rupture and the release of debris, highlighting limitations of punch biopsies for analysis.
19 citations
,
February 2021 in “International Journal of Pharmacognosy and Chemistry” This review discusses the pharmacological and pharmaceutical applications of Hibiscus rosa sinensis but does not report new findings, emphasizing its use as an excipient due to its medicinal properties.
19 citations
,
October 2019 in “Clinical and Experimental Dermatology” This study found that spironolactone significantly reduced pain, lesion count, and disease severity in patients with hidradenitis suppurativa, as reported in multiple patient cohorts.
19 citations
,
August 2018 in “JAMA dermatology” This study found that skin mesenchymal stem cells from hidradenitis suppurativa patients overexpress proinflammatory and anti-inflammatory cytokines, suggesting their potential contribution to the disease's pathogenesis.
19 citations
,
March 2018 in “JAMA” This guideline discusses the evaluation and treatment of hirsutism in premenopausal women, recommending oral contraceptive pills or antiandrogens as initial therapies with weak support from low-quality evidence.
19 citations
,
July 2017 in “Pediatric Dermatology” This study reports that finasteride was associated with an improvement in hidradenitis suppurativa among children aged 6 to 11, with no observed adverse effects.
19 citations
,
November 2015 in “Radiation Oncology” This study found that hippocampus sparing whole brain radiation therapy (HS-WBRT) using multi-field intensity modulated radiation therapy prevents alopecia without compromising cognitive function compared to traditional whole brain radiation therapy.
19 citations
,
March 2013 in “Journal of Cutaneous Pathology” This case report describes a 26-year-old female with linear morphea and unique alopecia characterized by atrophic follicular remnants, resembling telogen follicles but indicating permanent alopecia, unlike typical findings in morphea-related alopecia.
19 citations
,
January 2013 in “Annals of Dermatology” In this study, oral steroid pulse therapy was found to be as effective and well-tolerated as intravenous pulse therapy in treating severe alopecia areata, especially when started within one year of disease onset.