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This study found that induced expression of mir-302 can reprogram human hair follicle cells into induced pluripotent stem cells through a novel epigenetic mechanism involving global demethylation.

Human hair follicles can provide stem cells for regenerative medicine.

This study demonstrated that human hair follicle stem cells can be efficiently differentiated into endothelial-like cells using VEGF and bFGF, suggesting their potential as a novel cell source for vascular tissue engineering.

In this study, researchers developed a method to efficiently derive contractile smooth muscle cells from human hair follicle stem cells using TGF-β1 and PDGF-BB, which may advance vascular tissue engineering.

This study established an efficient short-term culture system for human hair follicle stem cells using human fibronectin and ROCK inhibitor Y-27632, enhancing cell proliferation and stemness for potential applications in hair follicle tissue engineering.

This study found that erythrocytes can be generated from human hair follicle mesenchymal stem cells with OCT4 expression, potentially serving as an alternative source for transfusions.

This study suggests that interfollicular epidermal keratinocytes with stem-like features may serve as an alternative to follicular keratinocytes for hair regeneration by supporting hair follicle morphogenesis in vivo.

This study found that reinforcing clayey soil with human hair fibers increased its strength significantly, both before and after freeze-thaw cycles, suggesting its potential use in cold climate zones.

This study found that human hair follicle-derived mesenchymal stem cells effectively maintained human embryonic stem cells in an undifferentiated state, comparable to mouse embryonic fibroblasts under standard conditions.

This study found that a combination of oral compounds improved metabolic activity, cell viability, and proliferation in hair follicular keratinocytes, with L-cystine playing a key role in protection against oxidative stress.

This study found that silencing SRD5A2 and applying melatonin significantly boosted proliferation and migration of human hair follicle stem cells without causing differentiation, while increasing MT1 expression and reducing 5-alpha-reductase levels.

This study found that treating male rats with human hair follicle stem cells improved memory function impaired by streptozotocin and increased both neurotrophic and inflammatory markers, suggesting potential neuroprotective effects in this model.

In this study, researchers explored how hypoxic preconditioning affects the survival and oxidative stress resilience of nestin-expressing hair follicle stem cells and SH-SY5Y neuroblastoma cells, focusing on changes in gene expression for HIF1α, BDNF, and VEGF.

This study found that an octapeptide binding to Lgr5 can enhance the proliferation and differentiation of human primary hair cells by activating the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for hair loss in androgenetic alopecia.

This study found that recombinant type III collagen may aid skin aging management by promoting fibroblast proliferation and migration, with a modest impact on inflammatory marker IL-6, though it did not significantly affect TNF-a secretion in vitro.

Ganoderma lucidum extract may help treat stress-related hair loss.

OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.

This study identified key regions and transcription factors, including SIX1 and FOXN1 itself, that regulate Foxn1 expression in thymic epithelial cells and hair follicle cells, offering insights into its transcriptional regulation.

This study investigated autophagy activator ICP5249 and found it promotes hair growth by enhancing cell proliferation and autophagy-related markers in human dermal papilla cells and hair follicles, with AMPKα playing a regulatory role, suggesting its potential as a hair growth ingredient.

This study found that OCT4-overexpressing human hair follicle mesenchymal stem cells show promise for artificial hematopoiesis by enhancing self-renewal through cytoskeletal remodeling and the beta-catenin-dependent adherens junction pathway.

This study found that prostaglandin D2 reduced proliferation in bulge resident K15+ stem cells but not in other K15+ progenitor cells, suggesting differential impacts on hair follicle stem cell niches.

In this study, researchers reported that the activation of EDA2R by p53 leads to p53-dependent cell death in cancer cells and is involved in chemotherapy-induced hair loss.

In this study, sildenafil was found to enhance human dermal papilla cell proliferation and promote hair growth in mice, suggesting potential use in alopecia treatment.

This study investigated the use of 3D cell culture technology to explore hair follicle regeneration, examining the impact of the 3D cellular environment on hair follicle morphogenesis and the effects of microwell depth on spheroid formation.

This letter to the editor comments on the association between androgenetic alopecia and increased scalp hardness, exploring the possible role of phosphodiesterase inhibitors but provides no new clinical results.

This study found that low molecular weight collagen peptide from fish may promote hair growth in both human cells and mice by activating the Wnt/β-catenin signaling pathway.

This study found that high-fructose intake in rats led to significant kidney histological changes, such as podocyte damage and inflammatory responses, which persisted even after returning to a standard diet.

This study established a new in vitro culture system that supports the growth and dynamic self-organization of hair follicle stem cells and their progeny, promoting a stable population equilibrium.

This review highlights the potential of ginseng and its metabolites in preventing hair loss, detailing their hair growth-promoting effects observed in numerous preclinical studies, and emphasizing the underlying mechanisms involved.