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This review examines the mechanisms of hair follicle development and regeneration, discussing current hair loss treatments and emerging therapies like low-level laser therapy and stem cell therapy, which the authors suggest show promise in managing hair loss.

In this study, the SFE-4 extract from coffee pulp demonstrated potential effects for treating androgenetic alopecia by enhancing cell proliferation and gene expression related to hair growth pathways in vitro, using human hair follicle dermal papilla and prostate cancer cells.

This study found that an octapeptide binding to Lgr5 can enhance the proliferation and differentiation of human primary hair cells by activating the Wnt/β-catenin signaling pathway, suggesting its potential as a treatment for hair loss in androgenetic alopecia.

This study found that the ashwagandha extracts ASH-Ext1 and ASH-Ext2 show different pharmacological activities in cell models due to their distinct withanolide proportions, highlighting the need for standardized extraction protocols to ensure consistent therapeutic efficacy.

This study observed that incorporating human follicle dermal papilla cells into fibrin microgels increased cell viability and the formation of hair follicle structures in in vitro skin cultures compared to traditional dermal papilla spheroids, suggesting a promising approach for hair follicle regeneration therapies.

This study found that oral administration of Terminalia bellirica enhanced hair growth in testosterone-suppressed conditions in both human cell and mouse models, outperforming finasteride, a current commercial hair loss treatment.

This study found that escin acts as a natural agonist of the Wnt/β-catenin signaling pathway in cultured human dermal papilla cells by promoting the degradation of GSK-3β, highlighting its potential therapeutic use for conditions like androgenetic alopecia and vitiligo.

In this study, Allium macrostemon Bunge extract was found to promote hair regrowth in a testosterone-induced androgenetic alopecia mouse model by activating Wnt/β-catenin signaling and boosting hair dermal papilla cell proliferation and growth factor expression.

This study found that WD-aptamer increased β-catenin expression and promoted human hair follicle dermal papilla cell proliferation by interfering with the CXXC5-Dvl1 interaction in the Wnt signaling pathway.

This study found that a single intradermal injection of human dermal papilla cells increased hair follicle number and thickness in pigs, suggesting potential effectiveness for hair growth in humans.

In this study, researchers observed that Indian head cactus extract significantly increased the proliferation of human follicle dermal papilla cells and induced the expression of hair growth-related genes, suggesting its potential as a new therapy for promoting hair growth.

This study found that the herbal extract HX109 promoted hair growth in mice by increasing cell viability and enhancing hair regrowth, with the effects increasing as doses rose.

The study found that safflower extract may help protect human follicle dermal papilla cells from cisplatin-induced damage, suggesting its potential as an adjuvant in chemotherapy to mitigate hair follicle cell damage.

This study found that polysaccharide extracts from ginseng, green tea, shiitake, and aloe vera effectively protected human follicle dermal papilla and keratinocyte cells by promoting cell proliferation or inhibiting apoptosis, suggesting potential for these extracts as ingredients in cosmetics or pharmaceuticals to prevent hair loss.

This study investigated how secretions from cultured human hair follicle-derived keratinocytes affect gene expression in human follicle dermal papilla cells to understand their signaling interactions.

This study found that human hair follicle dermal papilla cells grown in a 3D model influenced hair growth and immune pathways more effectively than those grown in a 2D culture.

This study found that an ethanolic extract from the microalga Tetrathelmis tetrathele exhibited anti-inflammatory effects, promoted the proliferation of certain skin and hair cells, and inhibited 5α-reductase activity, suggesting its potential as a therapeutic agent for preventing alopecia and enhancing scalp health.

This study highlights that stress-induced activation of the HPA axis in human hair follicles can lead to hair growth arrest, but variability in follicle response complicates potential therapeutic approaches.

This study reported that an anti-hair loss shampoo containing six active ingredients activated the Wnt/β-catenin pathway in human hair follicle dermal papilla cells in vitro.

In this study, Achyranthis Radix ethanol extract increased cell proliferation and hair growth-related protein expression in human hair dermal papilla cells, suggesting potential as a hair growth supplement.

This study found that essential oil from Coicis Semen increased cell proliferation and hair growth-related protein expression in human hair dermal papilla cells, suggesting potential for alopecia treatment.

This study suggests that L-(+)-Tartaric Acid may support hair growth by up-regulating certain genes in human Dermal Papilla cells, making it a potentially useful additive in minoxidil formulations.

This study suggests that Achyranthis Radix ethanol extract may promote hair growth by increasing cell proliferation and protein expression in human hair dermal papilla cells.

This study found that Ecklonia cava extract increased skin hydration and decreased redness, suggesting potential benefits for protecting and repairing scalp skin from pollutant-induced damage.

In this study, the researchers observed that Biofield Energy Healing Treatment significantly increased hair follicle cell proliferation in human dermal papilla culture, suggesting potential as a hair growth enhancer.

This study found that the application of polyunsaturated fatty acids, particularly arachidonic acid, promoted hair growth and anagen induction in both human dermal papilla cells and mouse models.

This study found that the lignan compound VB-1 may promote hair follicle growth by enhancing Wnt/β-catenin signaling and increasing dermal papilla cell proliferation in vitro.

This study found that VB-1, a vitexin compound, may promote human hair follicle growth by enhancing Wnt/β-catenin signaling in dermal papilla cells.

This study observed that Ginseng and Albizia extracts, when used together, protected human dermal papilla cells from oxidative stress-induced senescence, and inhibited genes that suppress hair growth, indicating their potential in preventing age-related hair density reduction.

This study found that Crataegi Fructus water extract may promote hair growth in mice by enhancing hair density, thickness, and length and activating the Wnt/β-catenin signaling pathway.