9 citations
,
March 2018 in “International journal of molecular sciences” This study suggests that the progesterone metabolite allopregnanolone and progesterone regulate distinct gene sets involved in glioblastoma cell proliferation, with some overlapping effects modified by finasteride.
8 citations
,
July 2022 in “Frontiers in plant science” This review outlines the current understanding of how pH contributes to root hair development and reports no new experimental findings.
3 citations
,
March 2023 in “International journal of molecular sciences” This review discusses the patterns and regulatory mechanisms of keratin expression in various biological conditions and reports no new experimental results.
2 citations
,
February 2023 in “International journal of molecular sciences” This study identified that copper depletion in dermal papilla cells reduced hair growth by boosting ROS levels, but ROS scavengers like NAC and ascorbic acid partially alleviated this effect.
231 citations
,
October 1999 in “Journal of Clinical Investigation” This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.
32 citations
,
May 2017 in “Lasers in medical science” This study found that radiofrequency treatment, with or without hydrolyzed collagen, increased dermis thickness, neocollagenesis, and FGF2 overexpression in rat skin tissue.
24 citations
,
March 2022 in “Genome biology” This study introduces scINSIGHT, a method that showed improved performance over existing approaches in identifying gene expression patterns and cellular processes in heterogeneous scRNA-seq datasets from different biological conditions.
8 citations
,
July 2019 in “Journal of Molecular Neuroscience” 1 citations
,
June 2021 in “Singapore Medical Journal” This study suggests that type I 5-alpha reductase may also play a role in hair growth, with dutasteride potentially being more potent than finasteride in modulating key hair growth gene expressions.
June 2025 in “Frontiers in Bioengineering and Biotechnology” In this study, the researchers observed that a recombinant human collagen complex with nicotinamide promoted hair growth in rat models, increased hair follicle stem cell survival, and enhanced key protein expression, suggesting potential benefits for hair health and loss prevention.
45 citations
,
September 2001 in “Journal of Investigative Dermatology” This study found that cyclosporin A stimulates growth in cultured murine hair epithelial cells and reduces protein kinase C expression, suggesting that these actions may contribute to its hair-growing effects.
August 2025 in “Tropical Journal of Natural Product Research” This study found that mint leaf and Aloe vera serum together significantly reduced CDK1 expression, which may help prevent chemotherapy-induced alopecia in rats, although only mint serum alone reduced CDC25 expression.
December 2024 in “International Journal of Molecular Sciences” This study observed that treating basal and squamous cell carcinoma cells with platelet-rich fibrin significantly reduced cell viability and increased apoptosis-associated gene expression, suggesting potential use as adjunctive therapy for localized nonmelanoma skin cancers.
This study identified the TALE homeodomain transcription factor Meis2 as a crucial regulator for the maturation and end-organ innervation of certain mechanoreceptors in mice, with its absence leading to altered sensory neuron structure and impaired touch sensitivity.
8 citations
,
February 2022 in “Molecules” This study found that Asparagus racemosus root extract significantly reduced facial sebum production and pore size in male volunteers, suggesting potential application as an anti-sebum ingredient in cosmetics.
7 citations
,
July 2024 in “Animals” In this study, the researchers observed that higher expression of the Sonic hedgehog gene in cashmere goats' hair follicle cycles is associated with increased cell proliferation and reduced apoptosis, suggesting its role in enhancing cashmere quality.
7 citations
,
April 2023 in “Biomedicines” This study found that sex hormones, specifically non-aromatizable androgens like DHT and A/T, significantly increase inflammatory cytokine expression in human adipocytes when stimulated by LPS.
24 citations
,
April 2013 in “PLOS ONE” This study identifies substance P, TNFα, and IFNγ as novel regulators of prolactin and its receptor expression in human skin, suggesting intracutaneous prolactin is not controlled by dopamine.
This study indicates that CD4 protein may have a functional role in basal cell-like keratinocytes through TCR/CD3-independent signaling, affecting their proliferation, differentiation, and migration.
15 citations
,
December 2020 in “International journal of molecular sciences” This review explores how epidermal stem cells contribute to the development and maintenance of various skin structures, and highlights specific markers and proteins associated with these cells, but reports no new clinical results.
2 citations
,
January 2022 in “Journal of Investigative Dermatology” This study reported that Hedgehog signaling in papillary fibroblasts is crucial for hair follicle regeneration during wound healing, emphasizing its potential for developing regenerative therapies in scarring wounds.
29 citations
,
July 2009 in “BJU international” This review examines the pharmacological properties and potential clinical benefits of 5α‐reductase inhibition in prostate cancer but reports no new research findings.
5 citations
,
September 2022 in “Antioxidants” This study found that the clionasterol-rich hexane fraction of Caulerpa racemosa may protect against particulate matter-induced skin damage by reducing oxidative stress and mitochondrial-mediated apoptosis in human keratinocytes and zebrafish.
100 citations
,
August 2011 in “Journal of Investigative Dermatology” Lack of vitamin D receptor increases skin tumor risk by boosting hedgehog signaling.
16 citations
,
May 2011 in “The Journal of clinical investigation/The journal of clinical investigation” This study in engineered mouse models suggests that some basal cell carcinomas may originate from hair follicle tissue stem cells upon leaving their stem cell niche.
1 citations
,
May 2025 in “Natural Products and Bioprospecting” In this study, PEVIII, a nanocomposite chitosan-coated vesicle containing both α-hederin and hederacoside C, demonstrated notable antibacterial activity against Pseudomonas aeruginosa in a keratitis model, showing significant lesion reduction, tissue improvement, and decreased bacterial load and inflammatory markers compared to other treatments.
96 citations
,
June 2017 in “Nature Communications” This study identified WNT10A as crucial for adult epithelial cell proliferation and differentiation, suggesting β-catenin pathway activation may help address regenerative defects in WNT10A mutation patients.
14 citations
,
May 2017 in “Journal of Investigative Dermatology” This study reports a novel homozygous mutation in the DST gene causing a unique form of epidermolysis bullosa simplex with prurigo papules in a 39-year-old Syrian man.
12 citations
,
July 2014 in “Journal of Investigative Dermatology” This study found that doxorubicin induces hair follicle apoptosis through TRAIL receptor signaling, providing insights for managing chemotherapy-induced hair loss.
2 citations
,
June 2025 in “Molecules” This review highlights that extracts from *Hamamelis virginiana* (witch hazel) exhibit antimicrobial, anti-inflammatory, antioxidant, and wound-healing properties in various studies, showing promise for future therapeutic use in dermatology and cosmetology, particularly for skin treatments.