This study found that GPC1 is a significant regulator of angiogenesis in human dermal microvascular endothelial cells, suggesting its potential as a target for alopecia research.
January 2021 in “Figshare” This study found that metformin may promote hair follicle regeneration by enhancing dermal cell activity in an in vitro mouse model, suggesting potential for treating pattern hair loss.
October 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that applying the right mechanical stretch to skin can activate hair stem cells and promote hair regeneration through a pathway involving WNT, BMP-2, and M2 macrophages.
March 2020 in “Research Square (Research Square)” This study found that adipose-derived mesenchymal stem cells from type 2 diabetes mice are slightly less effective than controls but offer similar therapeutic benefits for wound healing.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” In a laboratory setting, this study found that Biotrinine® dry extract activated hair follicle growth pathways and increased certain growth factor secretions in human dermal papilla cells, suggesting potential benefits for treating chronic hair loss.
This study found that Avicennia marina extract significantly increased hair growth in androgenic alopecia patients, suggesting its potential effectiveness by inhibiting 5 alpha-reductase and regulating relevant growth factors.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that infiltrating M2 macrophages promote wound-induced hair neogenesis in mice by producing growth factors that activate the wnt signaling pathway during the late phase of wound healing.
This study found that Avicennia marina extract and its active compound avicequinone C inhibit enzymes and receptors related to androgenic alopecia, potentially supporting hair growth in cultured dermal papilla cells.
January 2016 in “대한미용학회지” The study reported that lavender oil increased enzyme activity and cytokine expression linked to hair growth in C57BL/6 mice.
December 2015 in “OPAL (Open@LaTrobe) (La Trobe University)” This source provides procedural details without reporting new experimental findings or conclusions.
In this study, applying Yeast Constituent Extract twice daily for six months significantly improved hair growth and increased growth factor contents in patients with androgenic alopecia.
April 2014 in “The FASEB Journal” This study found that Geranium Sibiricum L extract may promote hair growth by increasing cell proliferation and migration while modulating cytokine expression in human dermal papilla cells under stress conditions.
January 2012 in “RWTH Publications (RWTH Aachen)” This study found that patient-derived HGF significantly accelerates wound healing in diabetic mice, particularly improving skin structure and flexibility, and rHGF plays a key role in boosting hair growth.
January 2010 in “Journal of Yangzhou University” In this study, sulfated fucans promoted hair growth in mice by advancing hair follicles to anagen IV and delaying their regression to catagen, possibly through VEGF and HGF effects.
This study examines various growth factors' roles in hair cell function and suggests insulin-like growth factor may stimulate hair growth, while the precise mechanism of growth inhibition remains unclear.
June 2005 in “Key Engineering Materials” This study found that biodegradable hydrogels loaded with various growth factors significantly enhanced hair follicle growth and blood vessel formation in mice, demonstrating a positive effect on their hair growth cycle.
This study found that hair growth is regulated by interactions between epithelial and mesenchymal cells, with various growth factors and hormones influencing different aspects of this process.
January 2003 in “Journal of Clinical Dermatology” This study found that cyclosporin A stimulated hair growth in mouse vibrissae follicles by promoting cell proliferation, reducing apoptosis, and altering the expression of certain growth factor mRNAs.
January 2000 in “Chinese Journal of Dermatology” This study found that the Chinese herb Ligustrum lucidum may enhance expression of hair growth-related genes, HGF and VEGF, in cultured mouse hair follicles.
January 2000 in “Linchuang pifuke zazhi” This study demonstrated that cyclosporin A upregulated mRNA expression of HGF and VEGF in cultured mouse vibrissa follicles.
June 2026 in “Korean Journal of Food Science and Technology” In this study, a 10% fermented Glycine max compound was found to promote faster hair growth and follicle formation in mice compared to 3% minoxidil, suggesting potential as a hair health supplement.
May 2025 in “Clinical Proteomics” In this study, researchers identified three proteins, DEFB1, HGFAC, and CYB5D2, as potential drug targets for alopecia areata, and suggested that the traditional Chinese medicine ingredient cimigenol shows promise in interacting with DEFB1 for potential treatment.
January 1999 in “Journal of S C C J” This study found that STAT3 signaling is essential for initiating the hair growth phase but not involved in hair follicle development during the fetal period.
4 citations
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July 2023 in “Frontiers in Microbiology” HGF combined with ADA is highly accurate for diagnosing tuberculous pleural effusion, especially in younger females.
1 citations
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December 2012 in “Journal of dermatological science” This study introduces ficlatuzumab, an anti-HGF monoclonal antibody, in combination with gefitinib in a phase 2 trial to address EGFR TKI resistance in Asian NSCLC patients.
12 citations
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February 2023 in “Stem Cell Research & Therapy” This study found that injecting hepatocyte growth factor-enhanced hair follicle stem cells into a rat model of ischemic stroke improved recovery by reducing inflammation, protecting the blood-brain barrier, and promoting angiogenesis.
39 citations
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May 2002 in “Oral Microbiology and Immunology” In this study, dihydrotestosterone increased proliferation and decreased IL-6 production in in-vitro fibroblasts from hereditary gingival fibromatosis and normal gingiva, effects partially reversed by anti-androgens.
10 citations
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May 2020 in “Clinical and Experimental Health Sciences” This study found that Tideglusib at 50nM stimulated Type-I collagen production in human gingival fibroblasts and osteoblasts, suggesting potential benefits for bone regeneration.
November 2024 in “Journal of Investigative Dermatology” This study explored the effects of red ginseng-derived components on aging skin cells and found they do not have senolytic properties but can alleviate signs of cellular aging and improve skin cell function by reducing senescence markers and inflammation.
April 2024 in “Research Square (Research Square)” This study found that extracts of mesenchymal stem cells (MSC-extract) and their protein components (MSC-protein) enhanced the proliferation and migration of periodontal ligament cells and induced significant periodontal tissue regeneration, showing potential as a new cell-free treatment for periodontal disease.