research Epigenetic Regulation in Adult Stem Cells and Cancers
Understanding how epigenetic regulation affects stem cells is key to cancer insights and new treatments.
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research Decorin Promotes Proliferation and Migration of ORS Keratinocytes and Maintains Hair Anagen in Mice
Decorin helps hair cells grow and move, and keeps hair growth phase going in mice.
research Granules of Finasteride and Cyclodextrin Obtained by Hot-Melt Extrusion to Target the Hair Follicles
Granules improve hair loss treatment by targeting follicles.
research Spatio-Temporal Regulation of Gene Expression Defines Subpopulations of Epidermal Stem Cells
Different types of skin stem cells can change and adapt, which is important for developing new treatments.
research Rheological Properties and Composition Affecting the Skin Permeation of a Model of a Hydrophilic Drug in Lecithin Reverse Wormlike Micelles
IPM enhances skin penetration of hydrophilic drugs.
research MicroRNA-205 Promotes Hair Regeneration by Modulating Mechanical Properties of Hair Follicle Stem Cells
MicroRNA-205 helps hair grow by changing the stiffness and contraction of hair follicle cells.
research Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State
Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
research Follicle-Targeted Delivery of Betamethasone and Minoxidil Co-Entrapped in Polymeric and Lipid Nanoparticles for Topical Alopecia Areata Treatment
Tiny particles improved delivery of hair loss treatments to hair follicles, with lipid-based particles performing best.
research Cross-Interactions of BMP and WNT Signaling Pathways Attenuate Androgen Effect on Hair Follicle Stem Cell Differentiation
BMPs are important for hair growth and can counteract the negative effects of androgens on hair follicle stem cells.
research Dental Derived Stem Cell Conditioned Media for Hair Growth Stimulation
Substances from dental stem cells might help treat hair loss.
research May the Best Wound WIHN: The Hallmarks of Wound-Induced Hair Neogenesis
Wounds can cause new hair growth in adult mice, influenced by Wnt signaling.
research Stem Cells, Organoids and Their Applications for Human Diseases: Special Issue of BMB Reports in 2023
Organoids created from stem cells are used to model diseases, test drugs, and develop personalized and regenerative medicine.
research ADAM17 Variant Causes Hair Loss via Ubiquitin Ligase TRIM47 Mediated Degradation
A variant in the ADAM17 gene causes hair loss by increasing protein degradation through TRIM47.
research Inducing Fate Changes at the Hair Follicle Stem Cell Niche
The study found that aging hair follicle stem cells change behavior, leading to hair loss, but drugs targeting these cells may help restore hair growth.
research Spheroid Cell Cultures as a Promising Study Model for Hair Follicle Regeneration
Culturing Dermal Papilla Cells and Hair Follicle Stem Cells in 3D conditions can significantly improve hair regeneration potential.
research Clinical Efficacy of a Cosmetic Treatment by Crescina Human Follicle Stem Cell on Healthy Males with Androgenetic Alopecia
Crescina® lotion helps reduce hair loss and increase hair growth in males with androgenetic alopecia.
research Gasdermin A3-Mediated Cell Death Causes Niche Collapse and Precocious Activation of Hair Follicle Stem Cells
Gasdermin A3 causes hair follicle stem cells to activate too early, leading to hair loss.
research Valproic Acid and/or Rapamycin Preconditioning Protects Hair Follicle Stem Cells from Oxygen Glucose Serum Deprivation-Induced Oxidative Injury via Activating Nrf2 Pathway
Valproic acid and rapamycin protect hair follicle stem cells from damage by activating a protective pathway.
research TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling
TLR2, a component in hair follicle stem cells, is crucial for healthy hair growth and regeneration, and its decrease can lead to hair loss.
research Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Affect Stem Cells in Human Scalp Hair Follicles
Collagen peptides may help maintain hair growth and could be beneficial for hair loss conditions.
research Bulge Cells of Human Hair Follicles: Segregation, Cultivation, and Properties
Researchers found that bulge cells from human hair can grow quickly in culture and have properties of hair follicle stem cells, which could be useful for skin treatments.
research Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells
The study demonstrated that the alkaline ceramidase 1 (ACER1) gene was crucial for maintaining the homeostasis of hair follicle stem cells (HFSCs) in mice by regulating ceramide metabolism. Mice deficient in the Acer1 gene exhibited elevated levels of ceramides and sphingoid bases, leading to progressive hair loss. The loss of Acer1 resulted in a widened follicular infundibulum and a reduction in HFSC survival and stemness. These findings suggested that ACER1 was essential for preserving the structure and function of hair follicles by controlling ceramide metabolism in the epidermis.
research Extracellular Proteoglycan Decorin Maintains Human Hair Follicle Stem Cells
Decorin helps keep hair follicle stem cells and may prevent age-related hair loss.
research Skin in the Game: Stem Cells in Repair, Cancer, and Homeostasis
Elaine Fuchs' research shows how skin stem cells maintain health, aid in healing, and are involved in cancer.
research Traditional Chinese Medicine Shi-Bi-Man Regulates Lactic Acid Metabolism and Drives Hair Follicle Stem Cell Activation to Promote Hair Regeneration
Shi-Bi-Man, a Traditional Chinese Medicine, helps grow hair by boosting lactic acid metabolism and activating hair follicle stem cells.
research MiR-27a Targeting PIK3R3 Regulates the Proliferation and Apoptosis of Sheep Hair Follicle Stem Cells
Blocking miR-27a increases sheep hair follicle stem cell growth and decreases cell death, which could help improve wool quality and treat hair loss.
research Restoration of Follicular β-Catenin Signaling by Mesenchymal Stem Cells Promotes Hair Growth in Mice with Androgenetic Alopecia
The study investigates the effects of human umbilical cord mesenchymal stem cells (hUCMSCs) on hair growth in androgenetic alopecia (AGA) model mice. Intradermal transplantation of hUCMSCs in these mice resulted in increased hair growth, hair follicle density, skin thickness, and activation of the anagen phase, while reducing apoptosis in dermal papilla cells (DPCs) and promoting hair follicle stem cell (HFSC) proliferation. The mechanism involves the activation of the Wnt/β-catenin signaling pathway in DPCs, which is crucial for hair regeneration. Blocking β-catenin degradation led to increased DPC apoptosis and reduced HFSC proliferation, highlighting the importance of this pathway in the therapeutic effects of hUCMSCs on AGA.
research Effects of Petasitin as Natural Extract on Proliferation and Pathological Changes of Pediatric Neuroblastoma SK-N-SH Cells
Tea tree oil may help treat scalp alopecia by promoting hair follicle stem cell growth.
research Natural Product Shi-Bi-Man Regulates Lactic Acid Metabolism and Drives Hair Follicle Stem Cell Activation to Promote Hair Regeneration
Shi-Bi-Man activates hair follicle stem cells and promotes hair growth by changing lactic acid metabolism and other cellular processes.
research Melatonin Protects K15+ Human Hair Follicle Stem Cells Against Paclitaxel-Induced Damage Ex Vivo
Melatonin may protect hair follicle stem cells from damage caused by chemotherapy.