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This study observed that tissue-engineered skin, using VEGF165 gene-modified cells embedded in astragalus polysaccharide-containing 3D printed scaffolds, enhanced early vascularization, and collagen and hair follicle regeneration, leading to improved skin repair in nude mice with full skin defects.

In an in-vitro study, researchers found that a specific concentration of Aloe Vera combined with injectable platelet-rich fibrin (i-PRF) significantly increased hair follicle stem cell proliferation compared to Aloe Vera or i-PRF alone, indicating potential benefits for alopecia treatment.

This study found that BMPs can counteract the inhibitory effects of androgens on hair follicle stem cell differentiation, highlighting their critical role in the pathway dysregulation seen in androgenetic alopecia.

Taxane chemotherapy can cause permanent hair loss by damaging hair follicles and altering their DNA.

This study identified a unique transcriptional signature in occipital hair follicles that may protect them from miniaturization in androgenetic alopecia, using an animal-free model to investigate gene roles.

This study found that both human and rat dermal papilla spheroids can induce hair follicle neogenesis, but larger spheroids increase inductivity without significantly affecting hair fiber diameter.

This study provides ex vivo proof-of-principle that low-intensity ultrasound may protect human hair follicles from paclitaxel-induced damage, potentially reducing chemotherapy-related alopecia.

This study found that hair follicles across mouse skin form a heterogeneous regenerative field, with distinct cycling dynamics influenced by the balance of activator and inhibitor signals, which could inform other organ regeneration research.

This study found that hair follicles in mouse skin use common activator/inhibitor signals to maintain cyclical hair growth across different regions, with varying dynamics influenced by distinct anatomical domains.

In this study, researchers found that the human hair follicle microbiota vary by anatomical compartment and donor age, with specific microbes like S. epidermidis potentially influencing hair follicle functions, which suggests new avenues for therapeutic targeting.

This study found that polycomb-group-mediated repression plays a key role in regulating hair follicle stem cell states and lineage progression by distinct mechanisms in adult mouse skin.

This study found that synchronized signals in the microenvironment regulate stem cell lineage choices in hair follicles by influencing chromatin dynamics during regeneration.

This review discusses the biology of hair follicle stem cells and highlights their potential for applications in regenerative medicine, drug, and gene delivery, but reports no new clinical results.

The researchers reported that in mice, prolactin signaling in the skin epithelium inhibits hair follicle stem cell activation, promoting quiescence during periods of high serum prolactin like pregnancy and lactation.

This study found that deletion of c-Jun and JunB in mouse bulge hair follicle stem cells was sufficient to trigger psoriasis-like skin disease through thymic stromal lymphopoietin signaling.

This article reviews how stem cell exhaustion contributes to aging, emphasizing the balance between proliferation and quiescence as crucial for long-term stem cell maintenance, but it reports no new results.

This research detailed a single-cell atlas showing dynamic hair follicle stem cell states associated with the hair cycle during aging in mice, highlighting differences in chromatin landscape linked to stem cell differentiation and quiescence, and providing a foundation for future exploration of aging reversal.

This study found that Ift20 is essential for hair follicle stem cell identity and hair regrowth, and it regulates keratinocyte migration during wound healing through focal adhesion integrin recycling, independently of ciliogenesis.

This article presents a comprehensive guide for classifying human hair follicle cycle stages in vivo using scalp xenografts on immunocompromised mice, offering valuable resources for researchers in the field.

This review discusses various non-invasive methods for diagnosing alopecia areata, highlighting that trichoscopy signs like short vellus hairs and yellow dots are sensitive indicators of the condition, while advanced imaging techniques provide valuable information on hair follicle status and scalp inflammation.

This study found that hair follicle mesenchymal stem cells improved liver function and pathology in a mouse model of liver cirrhosis, potentially by inhibiting the TGF-β/Smad pathway and reducing hepatic stellate cell activation.

This study found that combining human dermal papilla fibroblasts with hair matrix cells formed organoids capable of limited hair follicle development in ex vivo skin, but not fully formed hair follicles.

This review highlights the importance of using 3D scaffolds in vitro to support hair follicle regeneration, emphasizing how these structures help maintain cell function and mimic the natural environment, which is crucial for developing hair follicle organoids for transplantation.

This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.

This study found that squamous cell carcinomas from hair follicle stem cells are more prone to epithelial to mesenchymal transition and metastasis than those from interfollicular epidermis, due to distinct chromatin landscapes.

This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.

Hedgehog signaling helps keep hair follicle stem cells the same in both young and old human skin.

This review discusses the function and pathology of hair follicles and highlights the potential of using dogs as a model to study human hair and stem cell disorders, but presents no new experimental results.

This study found that in skin blister healing, hair follicle development is compromised as stem cells repair wounds at the expense of morphogenesis gene expression.