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This study found that inhibiting class I histone deacetylases in postnatal mouse dermal cells preserved their ability to induce hair follicles during culture by increasing specific gene expressions and activating the Wnt signaling pathway.

This study found that storing hair follicle grafts in chilled ATPv-supplemented saline was most effective for preserving trichogenic gene expression, compared to other storage solutions and temperatures.

This study found that combining platelet-rich plasma with adipose-derived mesenchymal stem cells significantly improved diabetic wound healing in rats by enhancing angiogenesis and modulating the Notch signaling pathway.

This study observed that using 3D dermal papilla microtissues enhances hair follicle regeneration and gene expression compared to 2D cultures, indicating their potential for hair growth drug screening.

Hair papilla cells are crucial for blood vessel development in hair follicles, affecting hair growth and loss.

This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.

This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.

This study observed that applying JAK-STAT pathway inhibitors to mouse and human skin led to rapid hair growth by inducing the anagen phase of hair follicles.

This study found that activating the Sonic hedgehog pathway in scarring wounds can remodel the dermis to promote hair follicle regeneration, highlighting a potential new approach to enhance healing.

This study found that disrupting Adam10 in the epidermis led to severe skin and multi-organ abnormalities, implicating Adam10 as crucial for proper Notch signaling and skin maintenance.

In this study, the researchers reported that Notch/CSL signaling is crucial for hair follicle differentiation, with Wnt5a signaling and FoxN1 acting as mediators in mice.

This study found that both human and rat dermal papilla spheroids can induce hair follicle neogenesis, but larger spheroids increase inductivity without significantly affecting hair fiber diameter.

This study suggests that exosomes derived from dermal papilla cells, especially those cultured in three dimensions, promote hair growth and regeneration by enhancing follicular cell activity.

In this review, the researchers detailed how the p63 transcription factor influences epithelial stem cell activities such as self-renewal, differentiation, and proliferation, highlighting the role of TAp63 and ΔNp63 isoforms in both normal tissue development and cancer pathogenesis.

This study developed a method for generating germ-like tissues called bbHFGs, which efficiently promoted hair follicle formation in mice, potentially advancing hair regenerative medicine applications.

This study suggests that down-regulation of vasculature-related genes in dermal papilla cells from balding scalps might contribute to the development of androgenetic alopecia.

In this study, researchers differentiated induced pluripotent stem cells into cells with dermal papilla-like properties, demonstrating their potential role in hair follicle bioengineering and drug testing for hair growth.

This research reviews the roles of dermal papilla signaling in hair follicle development and suggests new genetic tools could advance bioengineering therapies for alopecia, but it reports no new results.

This study found that a cocktail of three proteins from embryonic skin can enable adult fibroblasts to regenerate hair follicles by altering gene expression and activating regenerative signaling pathways.

This study found that HPV-150 and HPV-151 are rare genotypes with a preference for skin tissue, detected in some cases of skin lesions with generally low viral loads.

This review discusses strategies to regenerate human hair follicles using stem cells and reports no new experimental results; the authors note existing challenges and the potential of hiPSCs for future applications.

The researchers found that HOXC13 regulates different keratin proteins in a mixed manner, with certain SNPs impeding this regulation, while also demonstrating negative-feedback by HOXC13 and positive regulation by LEF1 and melatonin on the HOXC13 promoter.

This study found that 3D cultured hair follicle-like constructs, which include keratinocytes and dermal papilla cells, showed improved gene expression and cell interactions relevant to hair follicle development.

In this study, researchers established five new immortalized human dermal papilla cell lines from a male with androgenetic alopecia, which may serve as valuable tools for hair research.

This study identifies iRhom2 as a crucial regulator of hair follicle differentiation, showing that the iRhom2Uncv mutation leads to dysplasia and reduced TACE maturation, resulting in a hairless phenotype in mice.

This study suggests that 3D spheroid cultivation of dermal papilla cells can restore their hair-inductive capabilities, which are lost in 2D-cultured cells.

In this study, researchers developed a new 3D skin equivalent assay using mouse epidermal and dermal cells that successfully regenerated organized hair follicles, outperforming a 2D model in hair follicle orientation and quantity, and enhanced hair growth when Wnt3a was added.

This study suggests that human dermal fibroblasts can be converted into dermal papilla cell-like cells using microencapsulation, which may facilitate hair follicle regeneration in mice without chemical or genetic reprogramming.

Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

This chapter reviews signaling pathways related to androgenic alopecia in dermal papilla cells of balding human scalps, integrating published information and analysis of molecular interactions, without reporting new clinical results.