8 citations
,
March 2020 in “Fertility and Sterility” Operative hysteroscopy is still the main treatment for Asherman syndrome, but more research is needed on post-surgery methods.
8 citations
,
September 2018 in “Current Sexual Health Reports” Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.
8 citations
,
April 2013 in “Central European Journal of Biology” Melanocytes are diverse cells important for pigmentation and skin health, influenced by genetics and environment.
7 citations
,
October 2020 in “Journal of Clinical Medicine” Women with PCOS are at high risk of glucose metabolism issues and heart diseases, especially if overweight, highlighting the need for early intervention.
5 citations
,
November 2021 in “Saudi medical journal” The document reports three sisters with Woodhouse-Sakati syndrome showing typical symptoms and unusual gynecological anomalies.
4 citations
,
November 2017 in “Cancer Causes & Control” Men who start balding at age 20 may have a higher chance of getting aggressive prostate cancer.
2 citations
,
June 2006 in “Experimental dermatology” Skin patterns form through molecular signals and genetic factors, affecting healing and dermatology.
1 citations
,
November 2017 in “Expert opinion on orphan drugs” Scientists now better understand the genetics of hypohidrotic ectodermal dysplasia, leading to more accurate diagnoses and potential new treatments.
July 2019 in “Paediatrics and child health” The document concludes that personalized treatment, including lifestyle changes and medication, is essential for managing PCOS in teenagers, while also addressing their psychological well-being.
January 2015 in “Springer eBooks” The document concludes that managing PCOS involves lifestyle changes, medication, and monitoring for associated health risks.
January 2012 in “Methods in pharmacology and toxicology” TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.
1514 citations
,
January 2012 in “Fertility and sterility” Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.
438 citations
,
October 2010 in “Oncogene” Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.
431 citations
,
November 2008 in “Current Medicinal Chemistry” Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.
401 citations
,
January 2013 in “Postepy Dermatologii I Alergologii” The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.
349 citations
,
February 2005 in “The FASEB journal” Human skin can make serotonin and melatonin, which help protect and maintain it.
253 citations
,
May 2006 in “The Journal of Clinical Endocrinology and Metabolism” Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.
249 citations
,
November 2003 in “Clinical endocrinology” Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.
249 citations
,
April 2002 in “The FASEB journal” Human skin can make serotonin and melatonin.
211 citations
,
June 2012 The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.
197 citations
,
July 2009 in “American journal of human genetics” WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.
192 citations
,
September 2003 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.
184 citations
,
December 2014 in “Developmental Cell” Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
167 citations
,
January 2006 in “Gynecological Endocrinology” Women with PCOS have lower quality of life, especially in mental health and energy, and managing weight can help improve it.
131 citations
,
February 2010 in “Experimental Dermatology” The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.
131 citations
,
October 2004 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.
129 citations
,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
118 citations
,
May 2015 in “European journal of pharmaceutics and biopharmaceutics” The hydrogel with a 1:3 ratio of hydroxyethyl cellulose to hyaluronic acid is effective for delivering drugs through the skin to treat acne.
106 citations
,
November 2014 in “Cell Stem Cell” New single-cell analysis techniques are improving our understanding of stem cells and could help in treating diseases.
99 citations
,
December 2010 in “Journal of The European Academy of Dermatology and Venereology” The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.