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In this study, researchers found that the loss of SETDB1 in epidermal keratinocytes led to altered chromatin states, increased ERV expression, and activation of immune responses, while inhibiting these effects with certain antiviral drugs reduced skin inflammation and hair loss in a mouse model.

This study found that dermal papilla cells exhibit stage-dependent variation in histone methylation during the hair follicle cycle and display distinct chromatin marker expression when transitioning to in vitro culture.

This review explores how cell and mouse models have contributed to understanding the mechanisms of human aging, particularly focusing on Hutchinson-Gilford Progeria Syndrome, and reports no new clinical results.

This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.

This review discusses the senescence–stemness connection in cellular biology and reports no new findings, highlighting implications for both tissue repair and aggressive cancer behavior.

This article describes standard methods for studying DNA methylation dynamics in mouse skin and hair follicle stem cells but presents no new research findings.

This study found that more than 14% of idiopathic recurrent early pregnancy loss cases were associated with chromosomal heteromorphisms, predominantly 9qh+, suggesting a genetic component in these unexplained cases.

This review discusses the dynamic changes in chromatin organization and nuclear morphology during cellular processes like differentiation and disease, highlighting recent advances in understanding these epigenetic mechanisms without presenting new experimental findings.

This review highlights that surface mechanical regulation can program macrophage behavior through specific mechanical cues on material surfaces, potentially advancing immunotherapies and regenerative medicine by enabling precise control over macrophage functions.

This study found that repeatedly collecting hair follicles from individuals with fragile X syndrome is feasible for measuring FMR1 and FMRP levels in both home and office settings.

This study suggests that melatonin may have a radioprotective role against X-ray-induced skin damage in rats, as evidenced by milder injury markers in pretreated animals.

In this study, Trf1 genetic deletion in mice, including those with cancer-prone mutations, was shown to not affect overall viability and cause only mild effects, while being necessary for tumor formation, suggesting a potential therapeutic window for Trf1 as an anti-cancer target.

This review discusses the biochemical and biological functions of histone demethylases and their potential involvement in human diseases, including cancer, but reports no new findings.

This review explores recent insights into the diverse cell populations involved in skin development, homeostasis, wound healing, and cancer progression but reports no new results.

This review discusses the roles and mechanisms of chromatin remodelers and their subunits in mammalian development, but reports no new experimental results.

This review examines how epigenetic dysregulation affects adult stem cell function, noting that impacts range from minor to serious disruptions in tissue homeostasis and potential cancer development.

This review discusses the role of jumonji family proteins in chromatin regulation and development, highlighting their involvement in transcriptional repression and histone demethylation, but reports no new experimental findings.

Mammalian organs regenerate using stem cells and cell plasticity, but this ability declines with age.

This review discusses the WNT signaling pathway's involvement in human diseases and highlights recent advances in WNT-related treatments, but it presents no new research findings.

This review summarizes proposed pathophysiological mechanisms of postpartum depression, highlighting neuroendocrine and neurobiological changes, but reports no new findings and calls for integrated understanding of the disorder.

This study found that Myc activation in epidermal stem cells leads to chromatin modifications that promote stem cell exit and differentiation, which can be influenced by HDAC inhibitors like trichostatin A.

This study identified changes in transcription factor gene expression across various signaling pathways during inner ear hair cell regeneration in birds, revealing patterns and potential new pathways for future investigation.

In this study, researchers found that exposure to PM10 significantly increased inflammation and impaired collagen synthesis in human dermal fibroblasts, suggesting PM10 contributes to skin aging through these mechanisms.

This review discusses the role of lamins in development, tissue maintenance, and stress response, and does not report new experimental findings.

This review discusses the potential role of Wnt signaling in aging-related heart diseases and reports no clinical results.

This speculative review discusses hair cycle-dependent fibroblast dynamics and possible impacts on human hair growth, synthesizing current literature without presenting new clinical findings.

This review discusses the effects of valproic acid on immune cell activation and gene expression, potentially influencing infection outcomes and suggesting its promise for autoimmune and hypersensitivity condition management.

This review summarizes the current understanding of microRNAs in skin biology, highlighting their roles in processes like wound-healing and aging, without presenting any new experimental results.

This review discusses the molecular mechanisms of Hutchinson-Gilford progeria syndrome and evaluates current research trends, available mouse models, and prospects for developing therapies, but reports no new clinical findings.

This review discusses the dual role of cellular senescence in ageing and tissue repair and suggests potential therapeutic applications, with no new experimental results reported.