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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

Some alternative medicine treatments might work for skin conditions, but their effectiveness and safety differ a lot.

Studying premature aging syndromes helps understand human aging and suggests potential treatments.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Innovative biomaterials show promise in healing chronic diabetic foot ulcers.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

A new gene variant causes glucocorticoid resistance in a mother and son.

Siblings with signs of virilization should be tested for non-classical congenital adrenal hyperplasia, which does not affect adult height but may impact fertility and well-being if untreated.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Feather patterns form through genetic and epigenetic controls, with cells self-organizing into periodic patterns.

The study suggests certain ACE gene variations are more common in women with PCOS and may be linked to increased insulin resistance.

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

Women with PCOS face higher risks of diabetes and heart disease, and these risks increase with obesity.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

People with alopecia are at higher risk for heart disease and have more heart-related risk factors.

Some systemic treatments work for nail psoriasis but can have serious side effects.

The most common skin problems in Indian children are infections and eczemas.

People who carry the 21-Hydroxylase Deficiency gene are not more likely to have excessive male hormone levels.

Minoxidil and ranolazine together can reduce the spread of certain breast cancer cells.

Nuclear shape and chromatin changes affect gene expression in skin cell differentiation.

Finasteride may cause mental and sexual side effects, with hand preference and sexual orientation possibly affecting severity.

Early-onset baldness is linked to a higher risk of aggressive prostate cancer in African-American men, especially before age 60.

ECM-inspired wound dressings can help heal chronic wounds by controlling macrophage activity.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

New genes linked to ichthyosis were found, but there's still no cure; treatment options are improving.

Surgical removal of abnormal fat pads fixed the woman's eyelid issue caused by likely silicone injections.