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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Nanoemulsion-based drug delivery systems are versatile and have potential for treating various medical conditions and improving vaccines.

Women with PCOS are more likely to have fatty liver disease and worse metabolic health.

Severe insulin resistance can be managed with medication, lifestyle changes, and treatment for related conditions.

Transdermal testosterone can improve sexual desire in postmenopausal women but lacks long-term safety data and is not FDA-approved for this use.

People with Lichen Planus have thicker carotid artery walls, but it's not solely due to Lichen Planus when other factors are considered.

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

Finasteride effectively treats baldness but may cause sexual side effects.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

Hirsutism is a strong sign of high male hormones and metabolic problems in women with PCOS, but acne and hair loss are not.

SHBG may be a useful early indicator and treatment target for PCOS.

Women with PCOS often have more body hair, acne, and skin darkening, and these signs are linked to metabolic issues like insulin resistance and high cholesterol.

Spironolactone improved blood vessel function and cholesterol levels in non-obese women with PCOS.

Obese women with PCOS are more likely to have fatty liver disease.

Fat cells are important for tissue repair and stem cell support in various body parts.

Early balding men may have insulin resistance, but lifestyle changes can help.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

Improved Finasteride delivery for hair loss treatment.

Hair loss linked to metabolic issues and insulin resistance; early assessment may reduce future health risks.

High afamin levels are linked to metabolic syndrome and may predict its development in women with insulin resistance.

C-reactive protein helps monocytes stick to blood vessel cells by causing oxidative stress.

Early diagnosis and treatment of PCOS is crucial to reduce emotional distress and health risks.

Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.

Normal levels for certain hormones in Chinese women of reproductive age were identified.