This chapter reviews pharmacodynamic evaluations in endocrine disorders focusing on oral antidiabetics, insulin analogues, and hormone interactions, but reports no new results.
926 citations
,
June 2010 in “BMC Medicine” This review emphasizes the need for comprehensive guidelines to address the cardiometabolic and psychological features of polycystic ovary syndrome, alongside its reproductive aspects, and reports no new results.
883 citations
,
August 2016 in “Nature Reviews Disease Primers” This review discusses the current understanding of polycystic ovary syndrome, focusing on its epidemiology, pathophysiology, diagnosis, management, and future research directions, but reports no new clinical results.
343 citations
,
December 2008 in “Endocrine Reviews” This review discusses the various evidence-based and potential applications of metformin in treating and preventing symptoms and complications associated with polycystic ovary syndrome but reports no new clinical results.
200 citations
,
October 2009 in “European journal of endocrinology” This review discusses the multifaceted actions of metformin in polycystic ovary syndrome and reports no new clinical results; the authors emphasize metformin's potential benefits in both cardiometabolic and reproductive aspects of PCOS.
169 citations
,
August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology” This article discusses treatments for hirsutism and acne in women with polycystic ovary syndrome, suggesting that lower doses of current medications maintain efficacy while reducing cost and side effects, but reports no new clinical results.
144 citations
,
August 2019 in “Cells” This review discusses the WNT signaling pathway's involvement in human diseases and highlights recent advances in WNT-related treatments, but it presents no new research findings.
87 citations
,
July 2018 in “Biochimica et Biophysica Acta (BBA) - Molecular Cell Research” This review discusses the essential roles and complex regulation of PP2A in various physiological processes and reports no clinical results; the authors highlight the need for further mouse model research to explore PP2A's therapeutic potential.
69 citations
,
December 2005 in “Nature Clinical Practice Endocrinology & Metabolism” Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.
67 citations
,
July 2006 in “Clinics in Dermatology” This review discusses the dermatologic manifestations of hyperandrogenism in women and outlines the diagnostic approach and treatment options, reporting no new clinical results.
44 citations
,
April 2008 in “The Journal of Clinical Endocrinology & Metabolism” This study concluded that although RBP4 and adiponectin levels are associated with visceral fat, they do not independently contribute to the development of PCOS.
43 citations
,
October 2019 in “Pediatric Research” This review discusses the International Evidence-Based PCOS Guidelines, which aim to improve diagnosis and management of PCOS and its associated comorbidities, noting the importance of early intervention and healthy lifestyle changes; it reports no new results.
32 citations
,
January 2021 in “Molecules” This review compiles studies on the antidiabetic potential of plants from the Middle East, particularly from the Asteraceae and Lamiaceae families, but reports no clinical results.
29 citations
,
January 2014 in “Frontiers in physiology” This review examines the molecular mechanisms of the circadian clock and its effects on cardiovascular functions, proposing a novel non-invasive method using hair follicle cells to assess circadian regulation in humans, but reports no new clinical results.
19 citations
,
March 2007 in “Journal of diabetes science and technology” This study found that both metformin and rosiglitazone improved ovulation and insulin sensitivity in women with PCOS, with rosiglitazone showing a more pronounced increase in adiponectin levels.
18 citations
,
September 2015 in “Clinical Endocrinology” This study found that women with polycystic ovary syndrome have higher serum VEGF-B levels, which are linked to insulin resistance and decrease after metformin treatment.
18 citations
,
March 2014 in “Current Pharmaceutical Biotechnology” This review discusses metformin's use in women with polycystic ovary syndrome, focusing on benefits during pre-conception and pregnancy, but reports no new clinical results.
14 citations
,
July 2021 in “Reviews in endocrine and metabolic disorders” This study explores how SARS-CoV-2 interacts with endocrine organs and highlights specific endocrine molecules that help explain the progression and outcomes of COVID-19, especially in patients with certain metabolic conditions.
10 citations
,
November 2024 in “Cureus” This systematic review identified several factors contributing to increased cardiovascular risk in women with polycystic ovary syndrome, including insulin resistance, obesity, inflammation markers, and microbiota alterations linked to elevated trimethylamine-N-oxide levels.
9 citations
,
September 2000 in “Obstetrics and gynecology clinics of North America” This article reviews the psychological impact of hirsutism, particularly its prevalence among women, and provides no new clinical findings.
7 citations
,
January 2022 in “Animal Reproduction” This review examines rodent models to explore how maternal conditions like undernutrition, obesity, hypoxia, and androgen exposure affect fetal programming and metabolic outcomes in offspring, but presents no new clinical findings.
4 citations
,
July 2019 in “Children (Basel)” This review discusses recent findings on pathogenic mechanisms, diagnostic criteria, and treatment options for PCOS but reports no new clinical results.
4 citations
,
November 2012 in “Obstetrics, Gynaecology & Reproductive Medicine” This review describes therapeutic strategies for polycystic ovary syndrome, highlighting current treatments for ovulation induction and emphasizing lifestyle changes and personalized approaches, but reports no new clinical results.
4 citations
,
June 2006 in “Primary Care” This article reviews current diagnosis and treatment approaches for diabetes in adolescents, emphasizing a team-based management strategy, but provides no new clinical findings.
2 citations
,
January 2025 in “touchREVIEWS in Endocrinology” This study suggests that sodium-glucose cotransporter-2 inhibitors, alone or with metformin or GLP1RA, may improve metabolic and hormonal parameters in women with polycystic ovary syndrome.
2 citations
,
August 2020 in “International Journal of Cosmetic Science” This study suggests that Lindera strychnifolia root extract may help restore a healthy microbial balance on the scalp in men with androgenetic alopecia after 83 days of treatment.
2 citations
,
October 2008 in “The Journal for Nurse Practitioners” This review discusses the challenges in diagnosing polycystic ovarian syndrome due to its variable clinical features and emphasizes the need for early identification and intervention to prevent metabolic complications, but reports no new clinical results.
1 citations
,
June 2019 in “Innovare journal of medical sciences” This review examines the use of natural remedies, including various herbs, for treating polycystic ovary syndrome, but reports no new clinical results.
1 citations
,
May 2009 in “Wiley-Blackwell eBooks” Early treatment of PCOS in teens is crucial to prevent long-term health issues like diabetes and heart disease.
This article examines how digital technologies, drawing on Marshall McLuhan's concept of media as an "extension of man," transform design thinking by creating new possibilities without replacing it, emphasizing the need for a hybrid, reflective practice in design.