35 citations
,
August 2021 in “npj Regenerative Medicine” This review examines how fibroblasts contribute to regeneration in various organs and explores the potential of reverting adult fibroblasts to a fetal-like state for regenerative therapies, but reports no new empirical findings.
35 citations
,
January 2013 in “The Journal of experimental medicine/The journal of experimental medicine” This study found that deleting the CD98hc protein in mouse skin impairs wound healing and homeostasis, resembling aging effects, due to disrupted integrin signaling pathways.
32 citations
,
April 2016 in “Journal of Obstetrics and Gynaecology Research” This study found that women with polycystic ovary syndrome phenotypes A and B had the highest prevalence of metabolic syndrome, and that the visceral adiposity index may help predict metabolic risk.
31 citations
,
January 2014 in “Clinical Endocrinology” This study found no significant differences in metabolic characteristics between different phenotypes of PCOS or between women with PCOS and healthy controls among reproductive-aged Iranian women.
30 citations
,
April 2010 in “Cell Cycle” This review discusses how the p53 tumor suppressor gene helps maintain adult tissue homeostasis by promoting the removal of DNA-damaged cells, with implications for treating age-related diseases and p53-deficient cancers; it reports no new results.
28 citations
,
October 2013 in “Journal of The American Academy of Dermatology” In this study, ovarian SAHA was found to be independently associated with a more insulin-resistant profile and increased risk of glucose abnormalities in women with PCOS, beyond common risk factors.
26 citations
,
April 2019 in “Advances in wound care” This study found that tannic acid accelerated wound healing in rats by modulating inflammatory cytokines, increasing growth factors, and activating the Erk 1/2 pathway.
26 citations
,
June 2016 in “Journal of Reproductive Immunology” This study found that in women with polycystic ovary syndrome, xanthine oxidase activity is a useful marker for oxidative stress and is positively correlated with inflammatory markers and cardiovascular disease risk factors.
26 citations
,
July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” This review discusses the identification and roles of different epidermal stem cell types in skin homeostasis and repair, and reports no new experimental findings.
25 citations
,
October 2019 in “Journal of Endocrinological Investigation” This study reported that both drospirenone and chlormadinone acetate oral contraceptives had similar beneficial effects on clinical, metabolic, and hormonal parameters in women with polycystic ovary syndrome over six months.
25 citations
,
November 2014 in “British Journal of Dermatology” This study found various ABC transporters are transcribed in human hair follicles, suggesting their possible role in HF biology and potential for new therapeutic interventions.
25 citations
,
November 2008 in “Ophthalmic Plastic and Reconstructive Surgery” This study found no significant differences in sensation recovery or scar formation between radiofrequency and scalpel incisions in upper blepharoplasty, although radiofrequency caused greater tissue damage.
22 citations
,
November 2017 in “Scientific Reports” This study found that, despite a major depletion of SOX2-expressing stem cells in the pituitary, there was no effect on endocrine cell homeostasis or response to certain stressors in adult mice.
21 citations
,
August 1991 in “The Journal of Dermatologic Surgery and Oncology” This study found that intraoperative tissue expansion increased the amount of excised scalp by 20-30% during scalp reduction surgery for male pattern alopecia.
20 citations
,
January 2008 in “Journal of Korean Medical Science” This study found that NGAL expression increased in calcium-induced keratinocyte differentiation in vitro and was highly elevated in psoriasis-like skin conditions and skin cancers, suggesting a role in skin hyperplasia and homeostasis.
19 citations
,
November 2023 in “npj Regenerative Medicine” This study found that synthetic melanin particles applied topically in mouse injury models improved wound healing, showing potential as a therapy for accelerated healing, including in human skin explants.
19 citations
,
March 2007 in “Journal of diabetes science and technology” This study found that both metformin and rosiglitazone improved ovulation and insulin sensitivity in women with PCOS, with rosiglitazone showing a more pronounced increase in adiponectin levels.
18 citations
,
March 2020 in “Frontiers in Neuroendocrinology” This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.
17 citations
,
August 1979 in “Journal of The American Academy of Dermatology” This study found that a histochemical stain using 4-dimethyl-aminocinnamaldehyde effectively distinguishes between plucked anagen and telogen hairs by causing the root ends of anagen hairs to develop a red color.
15 citations
,
April 2018 in “Revista Brasileira de Ginecologia e Obstetrícia” In this study of women with polycystic ovary syndrome, insulin resistance was associated with obesity, waist circumference, lipid accumulation, and hypertension, with no significant difference in prevalence between different diagnostic methods.
15 citations
,
August 2013 in “Stem Cells and Development” This study proposes a two-step method that may enhance the generation of stem-like epidermal cells with superior proliferation and differentiation potential for skin regeneration.
14 citations
,
March 2023 in “Scientific Reports” This study found that in women with polycystic ovary syndrome, PCOS phenotype and oxidative stress markers were significantly related to free androgen index levels, but insulin resistance was not.
14 citations
,
July 2016 in “Fertility and Sterility” This study found that increasing the follicle number criteria for diagnosing PCOS to 25 per ovary excluded some women who continue to show evidence of metabolic risk.
13 citations
,
March 2022 in “Cell Death and Differentiation” This study found that while autonomous Sema3A expression limited keratinocyte migration and delayed wound healing, non-autonomous application of recombinant Sema3A with EGF enhanced wound repair in mice.
13 citations
,
September 2021 in “Communications Biology” This study introduces a five-modal microscopy technique that allows label-free, in vivo observation and quantitative analysis of various wound healing processes.
13 citations
,
February 2018 in “Plastic and Reconstructive Surgery” The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.
12 citations
,
June 2020 in “Dermatology and therapy” This article reviews major uses of platelet-rich plasma in treating various hair disorders, including both non-cicatricial and cicatricial alopecia, but reports no new results.
12 citations
,
January 2016 in “Endocrinology, diabetes & metabolism case reports” This report describes a 19-year-old male with 49,XXXXY syndrome receiving testosterone replacement therapy, which led to improvements in reproductive development, metabolism, and social interaction after a year of treatment.
12 citations
,
January 2013 in “IOSR Journal of Agriculture and Veterinary Science” In this study, homogenous platelet rich plasma gel improved wound healing in goats, showing organized collagen and new hair growth within 15 days without inflammation.
11 citations
,
October 2018 in “Hormone and Metabolic Research” This study found no difference in bone mineral density between young women with PCOS and age- and BMI-matched controls, but BMI significantly influenced BMD in women with PCOS.