474 citations
,
January 2012 in “Chemistry & biology” This review discusses the discovery and potential therapeutic uses of proteasome inhibitors across various diseases, including cancer and autoimmune conditions, but does not present new clinical data.
139 citations
,
February 2010 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.
68 citations
,
May 2013 in “The American journal of medicine” This report documents two cases of severe systemic poisoning from heavy metals after short-term use of traditional Chinese medicines for treating damaged or infected tissue.
12 citations
,
November 2014 in “Journal of Cutaneous Medicine and Surgery” This report describes a case where oral valganciclovir treatment led to improved skin texture and hair regrowth in a patient with trichodysplasia spinulosa.
5 citations
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February 2022 in “Supportive Care in Cancer” This study found that age is the most significant risk factor for hemorrhagic cystitis after hematopoietic stem-cell transplantation, with additional risk factors including cyclophosphamide-based prophylaxis and, among male recipients, prostatic hyperplasia.
June 2026 in “Saudi Medical Horizons Journal” This review discusses the role of JAK inhibitors in treating atopic dermatitis, alopecia areata, and vitiligo, highlighting their effectiveness and safety considerations but stressing the need for further research on long-term safety and patient selection.
March 2026 in “Clinical Cosmetic and Investigational Dermatology” In this case report, a 30-year-old woman with myasthenia gravis developed vitiligo and alopecia universalis during long-term rituximab therapy. Discontinuation of rituximab and initiation of oral baricitinib led to improvement in skin conditions, underscoring potential immune-related skin effects from rituximab.
February 2026 in “Oncology Reviews” This review highlights the promising clinical outcomes of sacituzumab tirumotecan (sac-TMT), an antibody-drug conjugate for breast cancer that targets TROP2, demonstrating improved response rates and progression-free survival, with manageable safety concerns including primarily mild-to-moderate nausea and alopecia.
March 2025 in “OncoTargets and Therapy” This study found that in circulating tumor cells from non-invasive liquid biopsies, the GG genotype of the CYP3A5 A6986G affects longer disease-free survival in DLBCL patients, highlighting the significance of circulating biomarkers for prognostic evaluation.
June 2020 in “Journal of Investigative Dermatology” This study observed that insurance coverage for oral tofacitinib in alopecia areata patients was difficult to obtain, with 71% of patients ultimately not receiving approval despite the drug's efficacy as an off-label treatment.
December 2018 in “International Journal of Research -GRANTHAALAYAH” This study reports that pulsed biomagnetic fields may play a role in the deformation of red blood cells by facilitating cross-talk between RBCs and human hairs in vitro.
December 2017 in “Actas Dermo-Sifiliográficas” Scalp cooling reduces chemotherapy-induced hair loss without increasing risk of skin metastases.
12 citations
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January 2011 in “Dermatologic Surgery” This entry contains only a placeholder abstract with no research findings described or summarized.
10 citations
,
January 1994 in “Advances in pharmacology” This review examines the role of topoisomerase-interacting drugs in cancer treatment and emphasizes the importance of understanding their mechanisms for clinical development, but it presents no new results.
February 2024 in “Curēus” This case report describes an 83-year-old man who developed focal neurotoxicity, including paralysis and pain, in the area treated with topical 5-fluorouracil cream for actinic keratoses, suggesting a potential neurotoxic risk associated with the drug, especially in those with a specific genetic deficiency.
36 citations
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May 2015 in “Australasian Journal of Dermatology” This case report described cosmetically significant hair regrowth in a 39-year-old woman with permanent chemotherapy-induced alopecia after continuous oral minoxidil use.
44 citations
,
August 1996 in “Drugs & Aging” Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.
9 citations
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January 2018 in “Acta Clinica Croatica” This review suggests that bendamustine, alone or in combination, shows effectiveness in treating indolent non-Hodgkin lymphoma and chronic lymphocytic leukemia, with recent studies highlighting its benefits especially in combination therapies, while balancing efficacy with a favorable toxicity profile.
2 citations
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August 2019 in “Asian journal of pharmaceutical and clinical research” This study found that in female breast cancer patients, supplementation with 400 mg IND02 (Cinnamon bark extract) thrice daily during chemotherapy significantly reduced severe weight loss and hair loss compared to placebo, with the treatment being well-tolerated and safe.
July 2026 in “International Journal of Applied Pharmaceutics” This review discusses the dermatological and systemic adverse effects of hair dye use, particularly focusing on the common allergen para-phenylenediamine, and reports no new clinical data.
76 citations
,
June 2018 in “EMBO Reports” This study demonstrates that YAP and TAZ are essential for initiating basal and squamous cell carcinomas in mice, and suggests targeting these pathways could be beneficial for treating skin cancers.
68 citations
,
September 2018 in “Trends in Cell Biology” This review discusses the senescence–stemness connection in cellular biology and reports no new findings, highlighting implications for both tissue repair and aggressive cancer behavior.
48 citations
,
September 2013 in “Oncologist” This study reported that alopecia is a common but often underreported side effect of endocrine-based cancer therapies, with tamoxifen showing the highest incidence of hair loss among analyzed treatments.
9 citations
,
July 2008 in “Oncology Reports” In this study, TC-1 cells, resembling stromal cells formed by epithelial-mesenchymal transition, significantly affected the behavior of normal human keratinocytes, supporting the role of stromal cells in tumor progression.
3 citations
,
February 1976 in “Pediatric Clinics of North America” This article discusses the factors influencing anticancer therapeutic regimens and reviews mechanisms of action and side effects of major chemotherapeutic agents without reporting new research findings.
136 citations
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April 2013 in “Clinical Cancer Research” The study found that IPI-926 was well tolerated up to 160 mg once daily for 28-day cycles and showed activity as a single-agent treatment in Hedgehog pathway inhibitor-naïve patients with basal cell carcinoma.
44 citations
,
September 2015 in “Annals of Oncology” This study reported that targeted anticancer therapies are associated with an increased risk of alopecia compared to placebo, although the risk was lower compared to chemotherapy.
16 citations
,
July 2021 in “Histopathology” This review discusses recent findings on molecular changes in cutaneous adnexal tumours and reports novel markers and pathways involved, highlighting the diverse oncogenic drivers and tumour suppressor alterations.
13 citations
,
December 2024 in “Cellular and Molecular Life Sciences” This study reviews recent advancements in understanding caspases, highlighting their roles beyond apoptosis in cancer, inflammation, and neurological disorders, and discusses the potential and challenges of targeting caspases for therapeutic purposes.
11 citations
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September 1999 in “Journal of the European Academy of Dermatology and Venereology” This review examines various immunomodulatory therapies for cutaneous lymphoma and notes that they are most effective in the disease's early stages.