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In this study, small molecule-loaded silk fibroin nanofiber scaffolds with chitosan achieved sustained release of GSK-3 inhibitor SB216763, leading to enhanced wound healing and hair follicle neogenesis in skin regeneration efforts.

High protein diets improve wound healing and hair growth in calves, regardless of energy intake.

This study observed that Fraser’s dolphins exhibit remarkable skin healing abilities, with type I collagen prevalent in normal skin and type III collagen emerging during early wound healing before returning to normal configuration, suggesting insights for human clinical wound management.

This study found that a single dose of 1 mg/kg dexamethasone promoted wound healing in septic mice but delayed it in normal mice.

This review discusses the heterogeneity and plasticity of epithelial stem cells in skin homeostasis, wound healing, and tumorigenesis, reporting no new results but emphasizing the need for further exploration of key regulatory mechanisms.

This study found that the methanolic extract of Carthamus caeruleus roots significantly reduced inflammation, promoted wound healing, and enhanced hair growth in experimental models, supporting its traditional use in Northern Algeria as a skincare remedy.

This case report describes an 80-year-old patient whose scalp wound healed by secondary intention, with unexpected hair regrowth observed at 180 days, suggesting hair neogenesis is possible even in older adults.

This study found that overexpression of sPLA2-IIA in homozygous mice resulted in cyclic alopecia, a halt in hair follicle cycling, and impaired wound healing due to complete loss of hair follicle stem cells.

This study in an animal model found that Rigenera® technology's use of autologous micrografts improved wound healing in diabetic rats by increasing factors like VEGF-A, IL4, and IL10 while reducing TNF-α and oxidative stress.

This study found that Datura metel extracts obtained through supercritical CO2 extraction demonstrated significant biological activity, including antioxidant and anti-inflammatory properties, and effectively promoted wound closure and collagen preservation, comparable to standard treatments, in laboratory experiments.

This study supports using mesenchymal stem cells cultured with collagen to accelerate skin wound healing in mice and canines, by enhancing epidermal repair and promoting factors essential for skin recovery.

In a murine burn wound model, this study found that an enhanced fractal self-pumping dressing significantly reduced wound area and tissue edema by efficiently draining excess exudates.

This study found that oral administration of naturally safe active polypeptides from marine shellfish promoted scarless dermal wound healing in mice, potentially via effects on inflammation, fibroblast activity, and the "skin-gut" axis.

In this study, a novel biofilm-dispersing wound gel did not interfere with healing and may enhance it by reducing inflammation in murine models with full-thickness skin wounds.

This study reports that mesenchymal stem cell-conditioned medium promoted dermal cell migration and proliferation, enhancing wound healing but not direct hair growth, in vitro and in adult mouse models.

This study observed that gerbils exhibit a different wound healing mechanism compared to mice, with lower TGF-B1 expression and distinct tissue responses, yet achieve similar healing outcomes.

This study found that suppressing Jagged1 in epidermal stem cells disrupted Notch signaling and resulted in poor-quality wound healing, suggesting a potential therapeutic target for improving wound repair.

This review highlights recent research using single-cell RNA sequencing and machine learning in wound healing, revealing significant insights into fibroblast diversity, immune cell dynamics, and the spatial organization of cells, which may transform therapeutic strategies for chronic wounds, fibrosis, and tissue regeneration.

This review explores the complex interactions between epidermal stem cells and their environment, highlighting the critical roles of these cells in skin wound healing and tissue repair processes.

This study found that using three-dimensional cell culture with Matrigel enhances the biological function and stemness of stem cells, leading to improved soft tissue repair and healing by activating the host microenvironment and autologous stem cells.

Aged skin heals slower due to more inflammation and disrupted cell communication.

This study observed that Hedgehog signaling in reticular and papillary fibroblast lineages plays different roles in wound repair and de novo hair follicle formation.

This study introduced the concept of spatiotemporal clocks to understand how different phases of mammalian wound healing are coordinated, with a focus on the spatial domains and oscillatory molecular signals involved, while highlighting the potential for regenerative therapeutic strategies.

This study found that injectable gelatin/metal/tea polyphenol double nanonetworks significantly accelerated wound healing in diabetic wounds by enhancing cell migration and providing anti-inflammatory and antioxidant properties, without detectable cytotoxicity in tests.

This study found that a silver ion cross-linked thiolated protein hydrogel, O3G7, significantly enhanced acute wound healing in mice by increasing collagen content, neovascularization, and reducing inflammation markers compared to a control group.

In this study, umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles were found to improve wound healing in type 2 diabetic mice by inhibiting macrophage pyroptosis and reducing oxidative stress levels.

In this study, a novel nanocomposite hydrogel was developed for diabetic wound care, demonstrating superior tissue adhesion, antibacterial properties, and healing capabilities in vivo and in vitro, while also allowing real-time pH monitoring to aid clinical management.

This systematic review found that chitosan-based wound therapy may accelerate wound healing by reducing inflammation and modulating immune response, but notes limited clinical trials to date.

In this study, Thy-1 was observed to play a critical role in wound healing in mice, particularly influencing vascular dynamics and blood perfusion during the healing process.

In this study, researchers reported that wound dressings made from bacterial cellulose composites modified with soybean protein (BC/7S and BC/11S) improved wound healing and reduced scarring in rat models, with BC/11S showing superior outcomes.