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NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.

Healing of heart and skin wounds in animals are similar.

Regulatory T-cells are important for healing and regenerating tissues in various organs by controlling immune responses and aiding stem cells.

Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

Humans have limited regenerative abilities, but new evidence shows the adult brain and heart can regenerate, and future treatments may improve this by mimicking stem cell environments.

New drugs for heart disease may be developed from molecules secreted by stem cells.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

Fibroblasts, cells usually linked to tissue repair, also help regenerate various organs and their ability decreases with age. Turning adult fibroblasts back to a younger state could be a new treatment approach.

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

Macrophages are essential for successful skin growth in reconstructive surgery.

Lizards can regrow their tails, and studying this process helps understand scar-free healing and limb regeneration.

Helminth protein helps wounds heal better by reducing scarring and promoting tissue growth.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Understanding and manipulating epigenetic changes can potentially lead to human organ regeneration therapies, but more research is needed to improve these methods and minimize risks.

The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.

Microneedles are effective for painless drug delivery and promoting wound healing and tissue regeneration.

Zebrafish need MYC and FGF to regenerate inner ear hair cells.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.

Fibroblast Growth Factors (FGFs) are important for tissue repair and regeneration, influencing cell behavior and other factors involved in healing, and are crucial in processes like wound healing, bone repair, and hair growth.

Certain mature cells in mouse lungs can turn back into stem cells to aid in tissue repair.

The document concludes that understanding adult stem cells and their environments can help improve skin regeneration in the future.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Bioprinting could improve wound healing but needs more development to match real skin.

Lymphatic vessels are essential for health and can be targeted to treat various diseases.

Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.

MG53 helps reduce skin damage caused by nitrogen mustard.