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Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

Men are more likely to have severe COVID-19 cases and fatalities than women due to factors like lifestyle, aging, and biological differences.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

New effective scar treatments are urgently needed due to the current options' limited success.

Some medicinal plants can help heal wounds and may lead to new treatments.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Skin fat helps with body temperature control and has other active roles in health.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

New methods for skin and nerve regeneration can improve healing and feeling after burns.

Hair mineral analysis might help diagnose diseases early, but standard methods are needed.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

Certain mice without specific receptors or mast cells don't lose hair from stress.

The dermal regeneration template is effective in skin regeneration, reducing scarring, and has potential for future improvements.

Electrospun nanofibers show promise for enhancing blood vessel growth in tissue engineering but need further research to improve their effectiveness.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.