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The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

The current system can't fully test all combination treatments, so alternative methods and regulatory flexibility are needed.

Valproic acid increases hair count in men with hair loss.

Hirsutism is excessive male-pattern hair growth in women, often caused by hormonal imbalances, and requires ongoing treatment to manage.

The document concludes that treating PCOS requires a combination of drugs to manage reproductive and metabolic symptoms, with more research needed on combination therapies.

Bariatric surgery may help severely obese teenagers but has risks and requires careful patient selection and long-term care.

5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.

Spironolactone might help protect against severe lung problems in COVID-19 patients.

Use finasteride, dutasteride, and minoxidil for hair loss treatment.

Losing eyelashes or eyebrows can be a sign of many different health problems and needs a careful approach to treat effectively.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Hormone treatments can help with women's skin and hair disorders, but they need careful monitoring and more research.

Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.

Activating Notch in adult skin causes T cells and neural crest cells to gather, leading to skin issues.

High afamin levels are linked to metabolic syndrome and may predict its development in women with insulin resistance.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Finasteride effectively treats hair loss in transgender men with few side effects.

Brazilian women with PCOS and both menstrual irregularity and high male hormone levels have a higher chance of having metabolic syndrome.

Young women with PCOS have a higher risk of high blood pressure and metabolic syndrome, but these risks may decrease after age 40.

Finasteride and minoxidil are effective FDA-approved treatments for androgenetic alopecia.

The research suggests that Tourette syndrome is linked to both brain signaling and immune system pathways.

Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

High-content screening is useful for finding new treatments for rare diseases and has led to FDA-approved drugs.

Lipocalin-2 levels are higher in women with PCOS and may indicate insulin resistance.

Women with PCOS have higher levels of certain blood clotting factors, suggesting a greater risk of cardiovascular issues.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

Vegetarian Indian women with PCOS have higher inflammation levels than non-vegetarians.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.