December 2020 in “Galen Medical Journal” This study found that patients with alopecia areata and androgenic alopecia had significantly increased mast cell infiltration, which was influenced by age and disease severity, especially in alopecia areata.
December 2020 in “Galen Medical Journal” This study observed that patients with alopecia areata and androgenic alopecia have significantly more perifollicular and perivascular mast cells compared to healthy individuals, particularly in those over 40 and with greater disease severity.
May 2026 in “Iconic Research and Engineering Journals” This review concluded that polyherbal hair oils, using key medicinal plants, may offer a validated and sustainable alternative to synthetic cosmetics for hair and scalp health, with potential for industrial standardization and clinical use.
13 citations
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April 2022 in “BMC Genomics” This study found that dandruff-afflicted individuals had a less integrated microbial network on the scalp and hair surface compared to healthy individuals, with more positive interactions and unstable connections.
July 2026 in “Clinical Cosmetic and Investigational Dermatology” In this study, a liposomal-encapsulated Sesbania grandiflora formulation significantly improved hair and scalp health in adults with hair loss over 180 days, showing enhanced hair density, thickness, growth rate, and tensile strength compared to placebo, with no related adverse events reported.
42 citations
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December 2015 in “International Journal of Clinical Pharmacology and Therapeutics” This study found that applying a novel 0.25% finasteride solution to the scalp can effectively reduce scalp DHT levels in men with androgenetic alopecia, potentially reducing systemic side-effects.
July 2026 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that the liposomal Sesbania grandiflora formulation significantly improved hair and scalp health in adults with hair loss compared to placebo over 180 days, enhancing factors such as hair density, thickness, growth rate, and tensile strength, with no related adverse events reported.
January 2026 in “BioNanoScience”
89 citations
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January 2013 in “Acta dermato-venereologica” This review examines dandruff and seborrheic dermatitis, highlighting the role of Malassezia yeasts in inflammation and hyper-proliferation, and reports no new clinical findings.
September 2025 in “Skin Research and Technology”
December 2024 in “International Journal Of Ayurvedic And Herbal Medicine” This review highlights Shirodhara's potential cosmetic benefits, noting improvements in scalp health, hair growth, and skin appearance, attributed to stress reduction, hormonal balance, enhanced circulation, and nutrient-rich herbal oils.
November 2025 in “Journal of Investigative Dermatology” Disrupted cell interactions in hair follicles contribute to hair loss in androgenetic alopecia.
November 2025 in “Cosmetics” In this exploratory randomized controlled trial, participants using a combination of Centella asiatica-derived extracellular vesicles with recombinant growth factors showed significant improvements in hair thickness, density, length, and reduced hair loss and scalp sebum content after 56 days, compared to placebo.
June 2026 in “Journal of Cosmetic Dermatology” This study reports that a novel multi-compound Blend, tested on ex vivo human hair follicles, promotes hair growth by enhancing elastin deposition and dermal papilla inductivity more effectively than isopropyl cloprostenate, suggesting benefits through elastogenesis and modulation of Wnt signaling.
April 2024 in “International journal of clinical trials” In this study, researchers found that a standardized extract of Sesbania grandiflora (SesZen-Bio™) improved hair density and thickness, as well as increased serum ferritin levels, over an 8-week period among participants, suggesting enhanced keratin production and follicle growth.
February 2026 in “Cosmetics”
128 citations
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February 2016 in “British Journal of Dermatology” This study found that patients with alopecia areata experience significant impairments in health-related quality of life, notably affecting mental health, according to various quality of life assessment tools.
47 citations
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November 2007 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This review discusses how various factors, including cosmetic procedures and scalp conditions, can damage hair, but highlights the availability of products to improve hair health; it reports no new empirical results.
This study analyzed scalp hair proteins from healthy children and their mothers, finding that non-structural proteins could serve as promising biomarkers for understanding long-term developmental changes and health status linked to early childhood experiences.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study developed a polyherbal hair mask containing neem, tulsi, fenugreek, amla, multani mitti, aloe vera, and tea tree oil, suggesting its effectiveness in sebum control, inhibiting Malassezia, and improving scalp health as a natural anti-dandruff treatment.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers formulated a polyherbal hair mask containing neem, tulsi, fenugreek, amla, multani mitti, aloe vera, and tea tree oil, and the expected results suggest its potential effectiveness for controlling sebum production, inhibiting Malassezia, and improving scalp health as a natural anti-dandruff treatment.
July 2021 in “CRC Press eBooks” This study reports that topical finasteride significantly reduced scalp and plasma dihydrotestosterone in men and women without altering serum testosterone levels, with promising preliminary results.
95 citations
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July 2016 in “Journal of The American Academy of Dermatology” This review concluded that patients with alopecia areata consistently show poor health-related quality of life scores, similar to those in other chronic skin diseases like atopic dermatitis and psoriasis.
4 citations
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March 2022 in “Dermatology and Therapy” This study found that alopecia areata severity significantly influences the health-related quality of life impacts and treatment patterns among affected individuals.
1 citations
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June 2020 in “British Journal of Dermatology” This article reviews the psychological impact of alopecia areata on patients, including lower self-esteem and poorer quality of life, and reports no new clinical results.
June 2026 in “Drugs & Therapy Perspectives” This study reports that patients with severe alopecia areata who experienced sustained scalp regrowth while receiving continuous baricitinib treatment showed improvements in health-related quality of life and reductions in anxiety and depression symptoms.
In this study, researchers found that the health state utility of moderate facial angiofibroma in Tuberous Sclerosis Complex patients is significantly lower compared to almost-clear facial angiofibroma, indicating that treatment for the condition can substantially improve quality of life.
April 2025 in “Brazilian Journal of Hair Health” This report from Tangle Teezer and TRI Princeton indicates that their Extra Gentle brush reduces hair breakage by up to 39%, offering a therapeutic experience for users with fragile scalps.
June 2023 in “Aesthetic Plastic Surgery” This study introduces the PRECISE scale, a quantitative tool to classify androgenetic alopecia, aiming to improve planning and outcomes for hair transplantation surgeries by evaluating the whole hairless and thinning areas.
7 citations
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August 2023 in “Skin Research and Technology” This study highlights age and sex as key factors influencing scalp parameters, thereby affecting hair health and suggesting they should be considered in developing hair care strategies.