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This study found that sebum free fatty acids may enhance the antibacterial defense of human sebaceous glands by upregulating the expression of the antimicrobial peptide hBD-2, potentially aiding in acne treatment.

This case report describes an 18-year-old male with kerion celsi from Trichophyton tonsurans infection whose condition improved with terbinafine treatment, and highlights that although IL-17A expression increased in skin lesions, it was associated with disrupted antimicrobial peptide expression and severe inflammation, causing tissue damage.

This study found that sphinganine may improve scalp health, hair quality, and reduce hair loss in males, potentially due to increased antimicrobial peptide levels and inhibition of 5-α-reductase.

This article provides clinical snippets from Experimental Dermatology and reports no new research findings.

R-spondin2 may help treat hair loss, gene differences could explain baldness, a peptide's regulation is linked to psoriasis, B-defensin gene copies may affect a skin condition's risk and severity, and potential markers and targets for alopecia areata were identified.

In this case-control study, the researchers found that human beta-defensin 1 concentration was not a significant predictor of alopecia areata susceptibility or severity.

This review explores the impact of vitamin D deficiency on the skin from a dermatological perspective, but reports no new clinical results.

This study found that a novel R343H mutation in the vitamin D receptor gene impairs its transcription activity, contributing to hereditary vitamin D-resistant rickets and alopecia in the affected family.

This study used in silico analysis to identify 4-[2-(4-nitrophenyl)ethylcarbamoyl]benzenesulfonyl as a potential inhibitor of the EGFR mutant associated with NSCLC, highlighting the need for further in vitro and in vivo validation.

This article discusses the development and clinical progress of PROTAC technology, particularly focusing on the New Drug Application for vepdegestrant, an estrogen receptor-targeting PROTAC, marking significant advancements in targeted protein degradation therapies.

This review discusses the developments in antifungal treatments for dermatophyte infections since 2008, reporting no new oral agents but introducing newer topical options like efinaconazole and tavaborole.

This article offers a viewpoint on hidradenitis suppurativa pathogenesis, suggesting that impaired Notch signalling from γ-secretase mutations may drive inflammation and link the condition to other Th17-driven diseases.

This review discusses the various roles of vitamin D in skin disorders, including established use in psoriasis and potential applications for atopic dermatitis and skin cancer prevention, but reports no new clinical results.

In this study, researchers observed that epidermal damage may increase susceptibility to Bacillus anthracis infection, allowing it access through hair follicles and the denuded dermis in mice.

This review discusses how dysregulated levels of eicosanoids, which are metabolites of phospholipids, may contribute to skin diseases like psoriasis and atopic dermatitis, suggesting the importance of targeted eicosanoid control in diagnosis and treatment.

This study found that treatment with vitamin D increased the expression of LL-37 through the vitamin D receptor in cultured sebocytes.

This review summarizes recent multidisciplinary advances in sebaceous gland research and highlights potential novel therapeutic strategies for skin diseases, but it reports no new clinical results.

This review examines recent findings on COVID-19 pneumonia treatment using mesenchymal stem cells and reports no new clinical results; the authors highlight MSCs' potential due to their immunomodulatory and tissue-regenerative properties.

This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

This review discusses the pathogenesis of common sebaceous gland diseases and their molecular pathways, but it reports no new clinical findings.

This review traces the historical understanding and treatment of acne across ancient Egyptian, Greek, and Roman civilizations, but provides no new clinical findings.

This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.

In this study, researchers found that intestine-derived human alpha defensin 5 enhances wound healing, reduces bacterial load, and promotes hair growth in murine burn wound beds by increasing LGR stem cell migration.

This review discusses the variety of skin disorders associated with atopic dermatitis, exploring their complex relationships and shared genetic and environmental factors, but reports no new clinical results.

This study observed that hairless HRS/J mice were resistant to Bacillus anthracis infection at the skin's surface, suggesting resistance may be due to increased dermal neutrophils rather than non-functional hair follicles.

In this study, botulinum toxin type A injections reduced the severity of treatment-resistant scalp psoriasis in more patients compared to placebo over a 12-week period.

This study introduces a modular fiber model to investigate how changes in microstructural properties of wool affect its critical buckling load, highlighting potential uses and areas needing further research in wool fiber biophysics.

In this study, researchers reported that compounds from Bruguiera gymnorhiza leaves showed anti-inflammatory potential in in silico analyses, with favorable drug properties and specific binding to the IKKβ receptor, suggesting possible development into anti-inflammatory drugs.

This study found that a methanolic extract of Sterculia foetida seeds demonstrated significant thrombolytic, anti-arthritic, analgesic, and antipyretic activities, with moderate cytotoxic effects in vitro and in vivo.