471 citations
,
October 2012 in “Cellular and Molecular Life Sciences” This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.
441 citations
,
May 2008 in “British Journal of Pharmacology” This article reviews the potential clinical use of anabolic steroids in treating muscle loss from chronic diseases and aging and highlights both the benefits and risks of these substances in sports.
256 citations
,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.
254 citations
,
January 2012 in “Nature Reviews Molecular Cell Biology” This review discusses the role of stem cell progeny as integral components of stem cell niches, offering feedback that may influence different stem cell systems' microenvironments, but it presents no new research findings.
232 citations
,
June 2012 in “Cold Spring Harbor Perspectives in Biology” This review summarizes the roles of Wnt signaling in wound healing but presents no new clinical findings, suggesting potential for Wnt-based therapies to enhance tissue regeneration.
225 citations
,
April 2018 in “Journal of Investigative Dermatology” Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.
223 citations
,
October 2020 in “Microsystems & Nanoengineering” This review discusses recent advances in microfabrication and microfluidic technologies for improving the production of organoids and spheroids, but it reports no new experimental results.
223 citations
,
September 2018 in “Rheumatology” This review examines clinical data on the efficacy and safety of JAK inhibitors used for immune-mediated conditions beyond rheumatoid arthritis, highlighting their potential therapeutic roles in various inflammatory diseases.
222 citations
,
October 2014 in “Annual Review of Pharmacology and Toxicology” This review discusses the roles of Eph receptors and ephrins in various diseases, highlighting their potential as therapeutic targets, but it presents no new research findings.
212 citations
,
September 2015 in “Journal of Investigative Dermatology” This article presents a comprehensive guide for classifying human hair follicle cycle stages in vivo using scalp xenografts on immunocompromised mice, offering valuable resources for researchers in the field.
211 citations
,
April 2013 in “Development” In this study, researchers found that the number of dermal papilla cells in hair follicles determines hair size and shape in mice, suggesting potential avenues for addressing hair loss.
208 citations
,
July 2001 in “Journal of The American Academy of Dermatology” This review discusses the classification and diagnosis of pregnancy-related skin conditions and reports no new clinical findings.
202 citations
,
August 2007 in “Biomaterials” This review discusses advancements in artificial skin for wound treatment and reports no new clinical findings; the authors highlight the potential of new biomaterials to enhance future skin replacement therapies.
191 citations
,
May 2018 in “British journal of dermatology/British journal of dermatology, Supplement” This study reviewed recent theories on alopecia areata's pathogenesis, highlighting its autoimmune nature due to immune privilege disruption in hair follicles, and noted current treatments have limited efficacy with high relapse rates, underscoring the need for further research into its mechanisms for better therapies.
188 citations
,
March 2018 in “Frontiers in Immunology” This review discusses the role of regulatory T-cells in tissue repair and regeneration across various organs and reports no new clinical results.
187 citations
,
April 2019 in “npj Regenerative Medicine” This study found that hMSC secretomes from umbilical cord Wharton's jelly had the most potent angiogenic effects, whereas those from adipose tissue demonstrated the weakest angiogenic potential.
185 citations
,
June 2014 in “Journal of Investigative Dermatology” This case report describes complete hair regrowth in a patient with alopecia universalis and improved psoriasis after treatment with the oral Janus kinase inhibitor, tofacitinib.
182 citations
,
June 2017 in “Biomaterials” This study found that adipose-derived mesenchymal stem cells produced more anti-inflammatory and pro-angiogenic cytokines on electrospun scaffolds, which enhanced wound healing and macrophage activity in a rat model.
170 citations
,
September 2019 in “Evidence-based Complementary and Alternative Medicine” This review discusses the use of 36 medicinal plant species for cutaneous wound healing and reports no new clinical results; the authors highlight the potential for these traditional practices to inform modern therapies.
139 citations
,
August 2018 in “Development” This review discusses the dynamic, niche-driven regulation of stem cell states in tissue homeostasis and regeneration, focusing on epithelial stem cells in the mammalian skin, intestine, and lung, without providing new experimental results.
139 citations
,
February 2010 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This review outlines the advancements in organ and tissue transplantation since the discovery of the human MHC and reports no new clinical results.
136 citations
,
May 2019 in “Cells” This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.
128 citations
,
August 2015 in “Cell Stem Cell” The researchers reported that dsRNA from damaged skin activates TLR3, promoting hair follicle regeneration, while TLR3-deficient animals fail to initiate this process, suggesting potential therapeutic approaches for hair neogenesis.
124 citations
,
February 2018 in “Nature Reviews Genetics” This review covers recent findings on stem cell plasticity under normal and cancerous conditions but presents no new experimental results, highlighting implications for regenerative medicine and cancer treatments.
123 citations
,
December 2015 in “Journal of Neuroendocrinology” This review discusses recent strategies targeting the neuroactive steroid biosynthetic pathway to enhance neurosteroidogenesis, highlighting their potential benefits for neurodegenerative and neuropsychiatric diseases, but reports no new clinical findings.
116 citations
,
February 2017 in “Journal of the American Academy of Dermatology” This systematic review found that Janus kinase inhibitors have shown beneficial effects for psoriasis and alopecia areata, with promising preliminary results in other skin conditions, though more research is needed to define dosing and safety profiles.
100 citations
,
June 2011 in “Journal of The American Academy of Dermatology” This study found that a once-daily 5% minoxidil topical foam is as effective as a twice-daily 2% minoxidil topical solution for hair growth in women with androgenetic alopecia, with fewer side effects and greater styling convenience.
98 citations
,
July 2014 in “Trends in Molecular Medicine” This article discusses the role of human hair follicles in neuroendocrinology and suggests potential new therapeutic targets by examining how neuromediators influence hair growth, pigmentation, and stem cell biology in organ cultures.
95 citations
,
December 1980 in “The New England Journal of Medicine” Minoxidil helped bald patient regrow hair.
90 citations
,
January 1979 in “International review of cytology” This chapter reviews the complexity of hair and wool follicle formation, emphasizing the importance of cytological studies to understand the relationship between cellular components.